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公开(公告)号：US20230096151A1
公开(公告)日：2023-03-30
申请号：US17936340
申请日：2022-09-28
发明人： Dean Michael Karantonis , Robert Bruce Gorman , Matthew Marlon Williams , Samuel Nicholas Gilbert , Milan Obradovic
摘要： Disclosed is an implantable device for lead offset determination, comprising first and second electrode leads. A stimulus is delivered from one lead to tissue, and a signal is sensed from the tissue by the other lead. The sensed signal is processed to produce a measure of a stimulus artefact present in the signal. The stimulus artefact measure is used to produce a measure of an offset between the first electrode lead and the second electrode lead, such as by applying a distance-squared. analytical model to measures of stimulus artefact obtained from at least two sense electrodes. And/or, a compound action potential evoked by the stimulus is sensed from neural tissue, a latency of the evoked compound action potential is measured, and a measure of an offset between the first electrode lead and the second electrode lead is produced from the latency.
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公开(公告)号：US11420064B2
公开(公告)日：2022-08-23
申请号：US17478793
申请日：2021-09-17
发明人： John Louis Parker , James Hamilton Wah , Dean Michael Karantonis , Milan Obradovic , Robert Bruce Gorman
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US20140296737A1
公开(公告)日：2014-10-02
申请号：US14117140
申请日：2012-05-11
CPC分类号： A61B5/40 , A61B5/04001 , A61B5/4029 , A61B5/4836 , A61B5/4893 , A61B5/686 , A61B18/14 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36139 , A61N1/36185
摘要： A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.
摘要翻译： 一种用于确定应用神经疗法的期望位置的方法。 电极阵列位于神经组织附近。 从阵列中施加刺激，其在靠近阵列的神经组织中引起神经化合物动作电位响应。 阵列的多个电极同时获得神经化合物动作电位响应的各自的测量值。 根据神经化合物动作电位响应的测量，确定神经治疗的期望位置。
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公开(公告)号：US11491334B2
公开(公告)日：2022-11-08
申请号：US17031749
申请日：2020-09-24
发明人： John Louis Parker , James Hamilton Wah , Dean Michael Karantonis , Milan Obradovic , Robert Bruce Gorman
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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