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公开(公告)号：US20230096151A1
公开(公告)日：2023-03-30
申请号：US17936340
申请日：2022-09-28
发明人： Dean Michael Karantonis , Robert Bruce Gorman , Matthew Marlon Williams , Samuel Nicholas Gilbert , Milan Obradovic
摘要： Disclosed is an implantable device for lead offset determination, comprising first and second electrode leads. A stimulus is delivered from one lead to tissue, and a signal is sensed from the tissue by the other lead. The sensed signal is processed to produce a measure of a stimulus artefact present in the signal. The stimulus artefact measure is used to produce a measure of an offset between the first electrode lead and the second electrode lead, such as by applying a distance-squared. analytical model to measures of stimulus artefact obtained from at least two sense electrodes. And/or, a compound action potential evoked by the stimulus is sensed from neural tissue, a latency of the evoked compound action potential is measured, and a measure of an offset between the first electrode lead and the second electrode lead is produced from the latency.
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公开(公告)号：US11420064B2
公开(公告)日：2022-08-23
申请号：US17478793
申请日：2021-09-17
发明人： John Louis Parker , James Hamilton Wah , Dean Michael Karantonis , Milan Obradovic , Robert Bruce Gorman
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US11491334B2
公开(公告)日：2022-11-08
申请号：US17031749
申请日：2020-09-24
发明人： John Louis Parker , James Hamilton Wah , Dean Michael Karantonis , Milan Obradovic , Robert Bruce Gorman
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
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公开(公告)号：US20160166164A1
公开(公告)日：2016-06-16
申请号：US14954529
申请日：2015-11-30
发明人： Milan Obradovic , Tracy Cameron , Robert Bruce Gorman , Nastaran Hesam Shariati , John Louis Parker
CPC分类号： A61B5/04001 , A61B5/407 , A61B5/4836 , A61B5/686 , A61B5/7282 , A61N1/0551 , A61N1/3605
摘要： An implantable device for monitoring for neural injury has a plurality of electrodes including stimulus electrodes and sense electrodes. A stimulus source provides a stimulus to be delivered to a nerve in order to give rise to an evoked action potential. Measurement circuitry records a neural compound action potential signal sensed at the sense electrodes. A stream of control stimuli are applied to the nerve over time and the evoked neural responses are measured. A diagnostic parameter of the measured neural responses is monitored over time, in order to detect a change in the diagnostic parameter. If a change in the diagnostic parameter occurs over time, an indication is output that neural injury has occurred.
摘要翻译： 用于监测神经损伤的可植入装置具有包括刺激电极和感测电极的多个电极。 刺激源提供刺激以递送到神经以引起诱发动作电位。 测量电路记录在感测电极处感测的神经复合动作电位信号。 随着时间的推移，对神经施加控制刺激流，并测量诱发的神经反应。 随着时间的推移监测测量的神经反应的诊断参数，以便检测诊断参数的变化。 如果诊断参数随时间发生变化，则输出发生神经损伤的指示。
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