-
公开(公告)号：US20140093913A1
公开(公告)日：2014-04-03
申请号：US14013236
申请日：2013-08-29
发明人： Gregory J. Cost , Philip D. Gregory , Dmitry Guschin , Michael C. Holmes , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Andreas Reik , Fyodor Urnov , Lei Zhang
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , C07K14/4702 , C07K14/805 , C07K2319/81 , C12N9/22 , C12N15/52
摘要： Methods and compositions for a genetic disease are provided.
摘要翻译： 提供遗传疾病的方法和组合物。
-
公开(公告)号：US09523098B2
公开(公告)日：2016-12-20
申请号：US13875992
申请日：2013-05-02
发明人： Vipula Shukla , Manju Gupta , Fyodor Urnov , Dmitry Guschin , Michiel Jan De Both , Paul Bundock , Lakshmi Sastry-Dent
CPC分类号： C12N9/0006 , A01C14/00 , C12N15/8213 , C12N15/8241 , C12N15/8243 , C12N15/8261 , C12N15/8269 , C12Y101/01037 , C12Y301/00 , Y02A40/146
摘要： Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
摘要翻译： 本文公开了用于靶向修饰一种或多种内源性植物苹果酸脱氢酶基因的方法和组合物。
-
公开(公告)号：US20140065667A1
公开(公告)日：2014-03-06
申请号：US13784634
申请日：2013-03-04
发明人： Dmitry Guschin , Fyodor Urnov
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , C07K14/4702 , C07K2319/81 , C12N9/22 , C12N15/10
摘要： Disclosed herein are methods and compositions for targeted deletion of double-stranded DNA. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, and polynucleotides encoding same. Methods for targeted deletion include introduction of such fusion proteins, or polynucleotides encoding same, into a cell such that two targeted cleavage events occur. Subsequent cellular repair mechanisms result in deletion of sequences between the two cleavage sites.
摘要翻译： 本文公开了用于靶向缺失双链DNA的方法和组合物。 组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白，以及编码它们的多核苷酸。 靶向缺失的方法包括将这种融合蛋白或编码其的多核苷酸引入细胞，从而发生两个目标切割事件。 随后的细胞修复机制导致两个切割位点之间的序列缺失。
-
公开(公告)号：US20140080216A1
公开(公告)日：2014-03-20
申请号：US14013250
申请日：2013-08-29
发明人： Gregory J. Cost , Philip D. Gregory , Dmitry Guschin , Michael C. Holmes , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Andreas Reik , Fyodor Urnov , Lei Zhang
CPC分类号： C12N15/85 , C07K14/4702 , C07K14/805 , C07K2319/81 , C12N9/22 , C12N15/52
摘要： Methods and compositions for a genetic disease are provided.
-
公开(公告)号：US09963715B2
公开(公告)日：2018-05-08
申请号：US14013236
申请日：2013-08-29
发明人： Gregory J. Cost , Philip D. Gregory , Dmitry Guschin , Michael C. Holmes , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Andreas Reik , Fyodor Urnov , Lei Zhang
IPC分类号： C12N15/85 , C12N15/52 , C12N9/22 , C07K14/47 , C07K14/805
CPC分类号： C12N15/85 , C07K14/4702 , C07K14/805 , C07K2319/81 , C12N9/22 , C12N15/52
摘要： Disclosed herein are nucleases and methods of using these nucleases for alteration of a globin gene and generation of cells.
-
公开(公告)号：US09695442B2
公开(公告)日：2017-07-04
申请号：US13784634
申请日：2013-03-04
发明人： Dmitry Guschin , Fyodor Urnov
CPC分类号： C12N15/85 , C07K14/4702 , C07K2319/81 , C12N9/22 , C12N15/10
摘要： Disclosed herein are methods and compositions for targeted deletion of double-stranded DNA. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, and polynucleotides encoding same. Methods for targeted deletion include introduction of such fusion proteins, or polynucleotides encoding same, into a cell such that two targeted cleavage events occur. Subsequent cellular repair mechanisms result in deletion of sequences between the two cleavage sites.
-
公开(公告)号：US09650648B2
公开(公告)日：2017-05-16
申请号：US14013250
申请日：2013-08-29
发明人： Gregory J. Cost , Philip D. Gregory , Dmitry Guschin , Michael C. Holmes , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Andreas Reik , Fyodor Urnov , Lei Zhang
CPC分类号： C12N15/85 , C07K14/4702 , C07K14/805 , C07K2319/81 , C12N9/22 , C12N15/52
摘要： Methods and compositions for a genetic disease are provided.
-
公开(公告)号：US20130326725A1
公开(公告)日：2013-12-05
申请号：US13875992
申请日：2013-05-02
发明人： Vipula Shukla , Manju Gupta , Fyodor Urnov , Dmitry Guschin , Michiel Jan De Both , Paul Bundock
CPC分类号： C12N9/0006 , A01C14/00 , C12N15/8213 , C12N15/8241 , C12N15/8243 , C12N15/8261 , C12N15/8269 , C12Y101/01037 , C12Y301/00 , Y02A40/146
摘要： Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
摘要翻译： 本文公开了用于靶向修饰一种或多种内源性植物苹果酸脱氢酶基因的方法和组合物。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.024 秒)
