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公开(公告)号：US20220363724A1
公开(公告)日：2022-11-17
申请号：US17813445
申请日：2022-07-19
申请人： SANOFI PASTEUR INC.
IPC分类号： C07K14/11 , C07K14/005 , C07K16/10 , G01N33/569
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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公开(公告)号：US11827668B2
公开(公告)日：2023-11-28
申请号：US17813445
申请日：2022-07-19
申请人： SANOFI PASTEUR INC.
IPC分类号： C07K14/11 , G01N33/569 , C07K14/005 , C07K16/10
CPC分类号： C07K14/11 , C07K14/005 , C07K16/10 , G01N33/569 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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公开(公告)号：US10927151B2
公开(公告)日：2021-02-23
申请号：US15580192
申请日：2016-06-09
申请人： SANOFI PASTEUR, INC.
IPC分类号： C07K14/11 , G01N33/569 , C07K14/005 , C07K16/10
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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公开(公告)号：US11427619B2
公开(公告)日：2022-08-30
申请号：US17147137
申请日：2021-01-12
申请人： SANOFI PASTEUR INC.
IPC分类号： C07K14/11 , C07K14/005 , G01N33/569 , C07K16/10
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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公开(公告)号：US20210130416A1
公开(公告)日：2021-05-06
申请号：US17147137
申请日：2021-01-12
申请人： SANOFI PASTEUR INC.
IPC分类号： C07K14/11 , C07K14/005 , C07K16/10 , G01N33/569
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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公开(公告)号：US20180162914A1
公开(公告)日：2018-06-14
申请号：US15580192
申请日：2016-06-09
申请人： SANOFI PASTEUR, INC.
IPC分类号： C07K14/11 , C07K16/10 , G01N33/569
CPC分类号： C07K14/11 , C07K14/005 , C07K16/10 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22 , G01N33/569
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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