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公开(公告)号：US20220363724A1
公开(公告)日：2022-11-17
申请号：US17813445
申请日：2022-07-19
申请人： SANOFI PASTEUR INC.
IPC分类号： C07K14/11 , C07K14/005 , C07K16/10 , G01N33/569
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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2.发明申请公开(公告)号：US20190175721A1
公开(公告)日：2019-06-13
申请号：US16258094
申请日：2019-01-25
发明人： Ted Milburn Ross , Tim Alefantis , Donald Martin Carter, JR. , Christopher Austin Darby , Harold Kleanthous
IPC分类号： A61K39/145 , A61K39/12
摘要： The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
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3.发明申请公开(公告)号：US20170368164A1
公开(公告)日：2017-12-28
申请号：US15537081
申请日：2015-12-18
发明人： Ted Milburn Ross , Tim Alefantis , Donald Martin Carter , Christopher Austin Darby , Harold Kleanthous
IPC分类号： A61K39/145 , A61K39/12 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C12N2760/16123 , C12N2760/16134
摘要： The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
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公开(公告)号：US11827668B2
公开(公告)日：2023-11-28
申请号：US17813445
申请日：2022-07-19
申请人： SANOFI PASTEUR INC.
IPC分类号： C07K14/11 , G01N33/569 , C07K14/005 , C07K16/10
CPC分类号： C07K14/11 , C07K14/005 , C07K16/10 , G01N33/569 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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公开(公告)号：US10927151B2
公开(公告)日：2021-02-23
申请号：US15580192
申请日：2016-06-09
申请人： SANOFI PASTEUR, INC.
IPC分类号： C07K14/11 , G01N33/569 , C07K14/005 , C07K16/10
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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公开(公告)号：US10925957B2
公开(公告)日：2021-02-23
申请号：US16258094
申请日：2019-01-25
发明人： Ted Milburn Ross , Tim Alefantis , Donald Martin Carter, Jr. , Christopher Austin Darby , Harold Kleanthous
IPC分类号： A61K39/145 , A61K39/12 , A61K39/00
摘要： Co-administration (for example, immunogenic cocktail compositions and/or prime boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides is provided. Coadministration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (for example, a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
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公开(公告)号：US10548965B2
公开(公告)日：2020-02-04
申请号：US15537109
申请日：2015-12-18
发明人： Ted Milburn Ross , Tim Alefantis , Donald Martin Carter , Christopher Austin Darby , Harold Kleanthous
IPC分类号： A61K39/145 , A61K39/00
摘要： The present invention provides co-administration (e.g., immunogenic cocktail and/or prime-boost regimens) of computationally optimized H5N1 influenza hemagglutinin (HA) polypeptides that. Co-administration of the optimized H5N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to multiple H5N1 influenza virus clades and strains.
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8.发明申请公开(公告)号：US20190111126A1
公开(公告)日：2019-04-18
申请号：US15537109
申请日：2015-12-18
发明人： Ted Milburn Ross , Tim Alefantis , Donald Martin Carter , Christopher Austin Darby , Harold Kleanthous
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5258 , A61K2039/545 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： The present invention provides co-administration (e.g., immunogenic cocktail and/or prime-boost regimens) of computationally optimized H5N1 influenza hemagglutinin (HA) polypeptides that. Co-administration of the optimized H5N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to multiple H5N1 influenza virus clades and strains.
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公开(公告)号：US10220086B2
公开(公告)日：2019-03-05
申请号：US15537081
申请日：2015-12-18
发明人： Ted Milburn Ross , Tim Alefantis , Donald Martin Carter , Christopher Austin Darby , Harold Kleanthous
IPC分类号： A61K39/00 , A61K39/12 , A61K39/145
摘要： The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
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公开(公告)号：US11427619B2
公开(公告)日：2022-08-30
申请号：US17147137
申请日：2021-01-12
申请人： SANOFI PASTEUR INC.
IPC分类号： C07K14/11 , C07K14/005 , G01N33/569 , C07K16/10
摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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