公开(公告)号：US3888877A

公开(公告)日：1975-06-10

申请号：US34468273

申请日：1973-03-26

申请人： SCHERING CORP

发明人： LEHN JEAN-MARIE

IPC分类号： C07C51/27 ,  C07C59/125 ,  C07C59/305 ,  C07C59/68 ,  C07C323/25 ,  C07D209/48 ,  C07D273/00 ,  C07D291/00 ,  C07D498/08 ,  C07D513/08 ,  C07D515/08 ,  C07F9/50 ,  C07F9/54 ,  C07F9/6571 ,  C07D93/00

CPC分类号： C07D209/48 ,  C07C51/27 ,  C07C59/125 ,  C07C59/305 ,  C07C59/68 ,  C07C323/25 ,  C07D273/00 ,  C07D291/00 ,  C07D513/08 ,  C07D515/08 ,  C07F9/5004 ,  C07F9/5449 ,  C07F9/657163

摘要： Novel macrocyclic (monocyclic and bicyclic) compounds having nitrogen bridgehead atoms and having in the hydrocarbon bridging chains at least two additional hetero atoms selected from the group consisting of sulfur, oxygen, and nitrogen, when admixed with a compatible cation-donor compound form stable cationcontaining macrocyclic complexes which, in turn, can be conveniently dissociated by addition of acid or a quaternizing agent. The novel macrocyclics are valuable for use in the same way and for the same purposes as chelating agents. The macrocyclic compounds are prepared by condensation reactions carried out via high dilution techniques, e.g. by condensing a substituted hydrocarbon di-carbonyl halide with a substituted hydrocarbon having terminal primary or secondary amino groups followed by reduction of the resulting lactam or, alternatively, by condensing a substituted hydrocarbon having terminal secondary or tertiary amino groups which have at least one hydrogenolyzable group with a substituted hydrocarbon di-halide (or di-sulfonate) followed by hydrogenolyzation of the macrocyclic compound thereby formed.