公开(公告)号：US3914058A

公开(公告)日：1975-10-21

申请号：US12039971

申请日：1971-03-03

申请人： SCHERING CORP

发明人： KNAPP JULIUS Z ,  HERSHBERG EMANUEL B

IPC分类号： G01N21/90 ,  G01N33/00 ,  G01N21/24

CPC分类号： G01N21/9027 ,  G01N21/9009 ,  G01N2033/0081

摘要： A method for detecting the presence of particulate matter in a liquid contained in a transparent container is disclosed as well as apparatus for performing the method. The preferred method includes the steps of rotating the container at a first relatively low rate of speed, rapidly stopping the container, immediately thereafter inspecting the rotating liquid in the container to determine if relatively lightweight particles are moving in the rotating liquid, rotating the container again to bring it to a second relatively high rate of speed, again rapidly stopping the container, and immediately thereafter inspecting the rotating liquid to determine if there are any relatively heavy particles moving in the rotating liquid.

摘要翻译： 公开了一种用于检测包含在透明容器中的液体中的颗粒物质的存在的方法以及用于执行该方法的装置。 优选的方法包括如下步骤：以第一相对较低的速度旋转容器，快速停止容器，立即检查容器中的旋转液体，以确定相对轻质的颗粒是否在旋转液体中移动，再次旋转容器 使其达到第二相对高的速度，再次快速停止容器，并且立即检查旋转液体以确定在旋转液体中是否存在相对重的颗粒移动。

公开(公告)号：US3901764A

公开(公告)日：1975-08-26

申请号：US46997274

申请日：1974-05-15

申请人： SCHERING CORP

发明人： WEINSTEIN MARVIN J ,  WAGMAN GERALD H ,  PATEL MAHESH G ,  MARQUEZ JOSEPH A

IPC分类号： C07D498/08 ,  C12D9/20

CPC分类号： C07D498/08 ,  Y10S435/863

摘要： A fermentation process for preparing rifamycin SV employing a heretofore unknown microorganism is described, said microorganism being classified as a member of the genus Micromonospora and being herein named, Micromonospora ellipsospora 71372.

公开(公告)号：US3898142A

公开(公告)日：1975-08-05

申请号：US45287074

申请日：1974-03-20

申请人： SCHERING CORP

发明人： GOLD ELIJAH H

IPC分类号： C07D205/04 ,  C07D205/06 ,  B01J1/10

CPC分类号： C07D205/06 ,  C07D205/04

摘要： Disclosed herein are novel N-acyl-3-aryl-3-azetidinols useful as intermediates. A method is provided for their direct preparation from acyclic starting materials. These N-acyl-3-aryl-azetidinols provide a convenient route to the 3-azetidinol series.

摘要翻译： 本文公开了可用作中间体的新型N-酰基-3-芳基-3-氮杂环丁烷。 提供了一种从无环原料直接制备的方法。 这些N-酰基-3-芳基 - 氮杂环丁烷醇提供了3-氮杂环丁醇系列的方便途径。

公开(公告)号：US3891761A

公开(公告)日：1975-06-24

申请号：US45892074

申请日：1974-04-08

申请人： SCHERING CORP

发明人： SHERLOCK MARGARET H

IPC分类号： A61K27/00

摘要： This invention relates to the N-methyl-D-glucamine salt of 2(2''-methyl-3''-trifluoromethylanilino) nicotinic acid and to its particular suitability as a parenterally administered analgesic agent.

摘要翻译： 本发明涉及2-（2'-甲基-3'-三氟甲基苯胺基）烟酸的N-甲基-D-葡糖胺盐及其作为肠胃外给药的止痛剂的特别适用性。

公开(公告)号：US3891677A

公开(公告)日：1975-06-24

申请号：US38031973

申请日：1973-07-18

申请人： SCHERING CORP

发明人： TANABE MASATO

IPC分类号： C07J7/00 ,  C07J21/00 ,  C07J41/00 ,  C07J75/00 ,  C07D13/04

CPC分类号： C07J21/00 ,  C07C2603/16 ,  C07J7/0045 ,  C07J7/007 ,  C07J41/0005 ,  C07J75/005

摘要： Steroidal 5-keto-4,5-seco-3-ynes of the estrane, androstane, and pregnane series are prepared from 3-keto-4-dehydro steroids via the 3-hydrocarbon-sulfonylhydrazono-4,5-oxido derivative thereof which undergoes fission and rearrangement in situ to form the 5keto-4,5-seco-3-yne structure. The 6- and/or 10-hydrocarbon substituted-5-keto-4,5-seco-3-ynes are prepared by reacting a 6and/or 10-unsubstituted-5-keto-4,5-seco-3-yne in an alkylating medium with a hydrocarbon sulfonate or, preferably, a hydrocarbon halide. The steroidal 5-keto-4,5-seco-3-ynes of this invention are useful as intermediates in preparing pharmacologically valuable 6- and/or 10-hydrocarbon substituted-3-keto-4-dehydro steroids, e.g. 1. BY REACTION WITH MERCURIC ACETATE AND SULFURIC ACID IN ACETIC ACID; OR 2. BY REACTION WITH MERCURIC OXIDE AND TRIFLUOROACETIC ACID FOLLOWED BY TREATMENT OF THE THEREBY FORMED 3,5-DIKETO-4,5-SEC. STEROID WITH POTASSIUM T-BUTOXIDE IN T-BUTANOL.

摘要翻译： 通过其3-烃基 - 磺酰基亚肼基-4,5-氧化物衍生物从3-酮-4-脱氢甾类化合物制备雌激素甾烷醇5-酮基-4,5-二硫杂环戊烷和孕烷系列， 在原位进行裂变和重排以形成5-酮-4,5-仲-3-炔结构。 6-和/或10-烃取代-5-酮-4,5-仲-3-炔通过6-和/或10-未取代的-5-酮-4,5-仲-3-基 - 在具有烃磺酸盐或优选烃卤化物的烷基化介质中。

公开(公告)号：US3857880A

公开(公告)日：1974-12-31

申请号：US17787171

申请日：1971-09-03

申请人： SCHERING CORP

发明人： SHERLOCK M ,  SPERBER N

IPC分类号： A61K31/19 ,  C07C69/76

CPC分类号： A61K31/19 ,  C07C69/76

摘要： Disclosed herein are 2-(4-biphenyl)-cyclopropane carboxylic acids, which compounds are useful in alleviating inflammation, pain, hypoglycemia and ketosis.

摘要翻译： 本文公开了2-（4-联苯基） - 环丙烷羧酸，该化合物可用于减轻炎症，疼痛，低血糖症和酮症。

公开(公告)号：US3852264A

公开(公告)日：1974-12-03

申请号：US21626372

申请日：1972-01-07

申请人： SCHERING CORP

发明人： WEINSTEIN J ,  COOPER D

IPC分类号： C07H15/236 ,  C07C47/18

CPC分类号： C07H15/236

摘要： Disclosed herein are oxazolidine derivatives formed by the condensation of aldehydes with gentamicin complex or its components. These compounds exhibit strong antimicrobial properties.

摘要翻译： 本文公开了通过醛与庆大霉素复合物或其组分的缩合形成的恶唑烷衍生物。 这些化合物表现出很强的抗菌性能。

公开(公告)号：US3819611A

公开(公告)日：1974-06-25

申请号：US15703071

申请日：1971-06-25

申请人： SCHERING CORP

发明人： WEINSTEIN M ,  LUEDEMANN G ,  WAGMAN G ,  MARQUEZ J

IPC分类号： C07H17/08 ,  C07C129/18

CPC分类号： C07H17/08 ,  Y10S435/863

摘要： A NEW ANTIBIOTIC COMPLEX IDENTIFIED AS ANTIBIOTIC W847 COMPLEX, (OR ANTIBIOTIC W847 OR MAGALOMICIN), COMPOSED OF AT LEAST FOUR MAJOR ANTIBIOTIC COMPONENTS IS DUCED BY THE CULTIVATION UNDER SUBMERGED AEROBIC CONDITIONS OF MICROMONOSPORA MAGALOMICEA, A HITHERTO UNDESCRIBED SPECIES OF THE GENUS MICROMONOSPORA OF THE ORDER ACTINOMYCETALES. THE INDIVIDUAL COMPONENTS ARE ISOLATED BY SOLVENT EXTRACTION AND CHROMATOGRAPHY AND ARE CHARACETERIZED BY THEIR RESPECTIVE CHEMICAL AND BIOLOGOICAL PROPERTIES.

公开(公告)号：US3810884A

公开(公告)日：1974-05-14

申请号：US9047470

申请日：1970-11-17

申请人： SCHERING CORP

发明人： GOLD E

IPC分类号： A61K31/33 ,  A61K31/445 ,  C07D203/14 ,  C07D207/16 ,  C07D211/60 ,  C07D211/78 ,  C07D25/00 ,  C07D27/04 ,  C07D29/24

CPC分类号： C07D203/14 ,  A61K31/33 ,  A61K31/445 ,  C07D207/16 ,  C07D211/60 ,  C07D211/78

摘要： DISCLOSED HEREIN ARE SUBSTITUTED 1-(1-ADAMANTYL)-2-CARBOXY-AZACYCLIC COMPOUNDS AND CERTAIN DERIVATIVES THEREOF. THEIR COMPOSITIONS ARE PARTICULARLY USEFUL IN THE TREATMENT OF PARKINSONISM.

公开(公告)号：US3784603A

公开(公告)日：1974-01-08

申请号：US3784603D

申请日：1972-07-13

申请人： SCHERING CORP

发明人： SHAPIRO E ,  TEUTSCH G ,  HERZOG H

IPC分类号： C07J41/00 ,  C07C173/10

CPC分类号： C07J41/0027

摘要： 6-AZIDO-21-OXYGENATED-4-PREGNENE-3,20-DIONES AND THE 1-DEHYDRO-, 6-DEHYDRO-, AND 1,6-BIS-DEHYDRO-ANALOGS THEREOF POSSESS CORTICOID PROPERTIES. PREFERRED ARE THE 6DEHYDRO ANALOGS, I.E. THE 6-AZIDO-21-OXYGENATED-4,6PREGNADIENE-3,20-DIONES, HAVING ENHANCED ANTI-INFLAMMATORY ACTIVITY. COMPOUNDS USEFUL AS INTERMEDIATES WHICH ALSO POSSESS GLUCOCORTICOID PROPERTIES ARE 6B-AZIDO-7AHYDROXY-21-OXYGENATED-4-PREGNENE-3,20-DIONES AND THE 7A-ACYLATES THEREOF. THE PREFERRED 6-AZIDO-21-OXYGENATED-4,6-PREGNADIENE3,20-DIONES ARE PREPARED BY TREATING A 6A,7A-OXIDO-4PREGNENE WITH AN ALKALI METAL AZIDE IN AN AQUEOUS, INERT ORGANIC SOLVENT; ESTERIFYING THE THEREBY FORMED 6B-AZIDO7A-HYDROXY-4-PREGNENE; AND TREATING THE RESULTING 6BAZIDO-7A-ACYLOXY-4-PREGNENE WITH A TETRAALKYLAMMONIUM HALIDE IN AN APROTIC SOLVENT. ALTERNATIVELY, THE 6-AZIDO4,6-PREGNADIENES ARE PREPARED BY TREATING A 6B-AZIDO-7AHYDROXY-4-PREGNENE OR 7A-ACYLATE THEREOF WITH CONCENTRATED HYDROCHLORIC ACID IN A LOWER ALKANOIC ACID IN AN INERT SOLVENT. THE 6A-AZIDO-21-OXYGENATED-4-PREGNENE-3,20-DIONES AND 1-DEHYDRO ANALOGS THEREOF ARE PREPARED BY TREATING A 6BHALOGENO-(OR 6B-SULFONYLOXY)-21-OXYGENATED-4-PREGNENE3,20-DIONE OR 1-DEHYDRO-ANALOG THEREOF WITH AN ALKALI METAL AZIDE IN AN INERT SOLVENT. THE 6-AZIDO-21-OXYGENATED - 1,4,6 - PREGNATRIENE-3,20DIONES ARE PREPARED BY TREATING A T-AZIDO-21-OXYGENATED4,6-PREGNADIENE-3,20-DIONE WITH 2,3-DICHLORO-5,6-DICYANOBENZOQUINONE IN THE PRESENCE OF A STRONG ACID AND WATER.