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1.
公开(公告)号:US10132819B2
公开(公告)日:2018-11-20
申请号:US15219456
申请日:2016-07-26
发明人: Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki , Masahiro Ieko
摘要: Disclosed is a method for measuring a clotting time, including: a mixing step of mixing a blood sample, an activator, a phospholipid, and a manganese ion-forming compound to obtain a specimen; and a measurement step of mixing the specimen obtained in the mixing step with a calcium salt to prepare a measurement specimen and measuring the clotting time of the measurement specimen, wherein the blood sample is mixed with the manganese ion-forming compound separately from the activator and the phospholipid in the mixing step.
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2.
公开(公告)号:US10908170B2
公开(公告)日:2021-02-02
申请号:US15219846
申请日:2016-07-26
发明人: Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki , Masahiro Ieko
IPC分类号: G01N33/86
摘要: Disclosed is a method for measuring a clotting time, including the steps of: (A) mixing a blood sample, an activator, a phospholipid, and a nickel ion-forming compound to obtain a specimen; and (B) mixing the specimen obtained in step (A) with a calcium salt to prepare a measurement specimen and measuring the clotting time of the measurement specimen.
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公开(公告)号:US09835635B2
公开(公告)日:2017-12-05
申请号:US15082005
申请日:2016-03-28
发明人: Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki , Masahiro Ieko
CPC分类号: G01N33/86 , G01N33/20 , G01N33/4905 , G01N33/564 , G01N33/6854 , G01N33/92 , G01N2800/224
摘要: Disclosed is a method for measuring clotting time including: preparing a measurement sample by mixing a blood specimen suspected to contain a lupus anticoagulant, an activator, and a divalent-metal-ion-producing compound for facilitating formation of a phospholipid-containing complex; and measuring a clotting time after adding, to the measurement sample, an aqueous solution of a calcium salt as a coagulation initiator.
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4.
公开(公告)号:US10578628B2
公开(公告)日:2020-03-03
申请号:US15686976
申请日:2017-08-25
发明人: Masahiro Ieko , Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki
摘要: The present invention relates to a method for acquiring information on a cause of prolongation of coagulation time. The present invention also relates to a device, a system and a computer program for analyzing blood coagulation.
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公开(公告)号:US10775393B2
公开(公告)日:2020-09-15
申请号:US15468887
申请日:2017-03-24
申请人: SYSMEX CORPORATION
发明人: Yusuke Tanaka , Takahiko Bando , Kiyoko Kohama , Haruki Yamaguchi
摘要: Disclosed is a reagent for prothrombin time measurement, wherein the reagent contains a liposome composition containing a first liposome having a phospholipid layer, a second liposome having a phospholipid layer of a different composition from that of the first liposome, and tissue factor, wherein the tissue factor is associated with the phospholipid layer of at least one of the first liposome and the second liposome; the first liposome contains a phosphatidylcholine compound, a phosphatidylethanolamine compound, and a phosphatidylserine compound; and the second liposome contains at least one phospholipid selected from the group consisting of a phosphatidylcholine compound and a phosphatidylethanolamine compound.
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