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1.发明授权公开(公告)号：US10132819B2
公开(公告)日：2018-11-20
申请号：US15219456
申请日：2016-07-26
发明人： Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki , Masahiro Ieko
摘要： Disclosed is a method for measuring a clotting time, including: a mixing step of mixing a blood sample, an activator, a phospholipid, and a manganese ion-forming compound to obtain a specimen; and a measurement step of mixing the specimen obtained in the mixing step with a calcium salt to prepare a measurement specimen and measuring the clotting time of the measurement specimen, wherein the blood sample is mixed with the manganese ion-forming compound separately from the activator and the phospholipid in the mixing step.
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2.发明授权公开(公告)号：US10578628B2
公开(公告)日：2020-03-03
申请号：US15686976
申请日：2017-08-25
发明人： Masahiro Ieko , Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki
摘要： The present invention relates to a method for acquiring information on a cause of prolongation of coagulation time. The present invention also relates to a device, a system and a computer program for analyzing blood coagulation.
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3.发明授权公开(公告)号：US10908170B2
公开(公告)日：2021-02-02
申请号：US15219846
申请日：2016-07-26
发明人： Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki , Masahiro Ieko
IPC分类号： G01N33/86
摘要： Disclosed is a method for measuring a clotting time, including the steps of: (A) mixing a blood sample, an activator, a phospholipid, and a nickel ion-forming compound to obtain a specimen; and (B) mixing the specimen obtained in step (A) with a calcium salt to prepare a measurement specimen and measuring the clotting time of the measurement specimen.
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4.发明授权公开(公告)号：US09933443B2
公开(公告)日：2018-04-03
申请号：US15082170
申请日：2016-03-28
发明人： Osamu Kumano , Naohiko Matsuo , Nobuo Arai , Masahiro Ieko
CPC分类号： G01N33/86 , G01N15/1456 , G01N21/51 , G01N21/77 , G01N21/82 , G01N33/4905 , G01N2015/1488 , G01N2021/825 , G01N2201/061
摘要： Disclosed is a blood sample determination method including: preparing a mixed plasma by mixing a subject plasma and a normal plasma; emitting light to a measurement specimen obtained by mixing the mixed plasma and a clotting time measuring reagent, to obtain optical information regarding an amount of light from the measurement specimen; and determining whether the subject plasma is suspected to be a coagulation-factor-deficient plasma, on the basis of optical information obtained from one measurement specimen.
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公开(公告)号：US09835635B2
公开(公告)日：2017-12-05
申请号：US15082005
申请日：2016-03-28
发明人： Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki , Masahiro Ieko
CPC分类号： G01N33/86 , G01N33/20 , G01N33/4905 , G01N33/564 , G01N33/6854 , G01N33/92 , G01N2800/224
摘要： Disclosed is a method for measuring clotting time including: preparing a measurement sample by mixing a blood specimen suspected to contain a lupus anticoagulant, an activator, and a divalent-metal-ion-producing compound for facilitating formation of a phospholipid-containing complex; and measuring a clotting time after adding, to the measurement sample, an aqueous solution of a calcium salt as a coagulation initiator.
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公开(公告)号：US10852312B2
公开(公告)日：2020-12-01
申请号：US16003560
申请日：2018-06-08
申请人： SYSMEX CORPORATION
发明人： Osamu Kumano
摘要： A determination method of a blood sample may include: measuring, with a first coagulation time measurement reagent and a second coagulation time measurement reagent which contain phospholipids at different concentrations, coagulation times of a blood sample of a subject, coagulation times of a normal blood sample, and coagulation times of a mixed sample including the blood sample of the subject and the normal blood sample; acquiring a first index value and a second index value based on the coagulation times; and determining whether the blood sample of the subject is a blood sample containing a direct anticoagulant based on the first index value and the second index value.
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公开(公告)号：US10753951B2
公开(公告)日：2020-08-25
申请号：US15883568
申请日：2018-01-30
申请人： SYSMEX CORPORATION
发明人： Osamu Kumano
摘要： Disclosed is a method for determining a blood specimen, comprising preparing a first measurement sample by mixing a blood specimen of a subject with a first coagulation time measurement reagent and measuring first coagulation time, preparing a second measurement sample by mixing the blood specimen with a second coagulation time measurement reagent and measuring second coagulation time, and acquiring a value based on the first coagulation time and the second coagulation time, wherein the second coagulation time measurement reagent contains a metal ion and/or normal plasma, and the value is used to determine whether the blood specimen of a subject is a blood specimen containing a lupus anticoagulant or a blood specimen containing a direct anticoagulant.
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