公开(公告)号：US20220088153A1

公开(公告)日：2022-03-24

申请号：US17422266

申请日：2019-10-22

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Hyun Chul JO ,  Seung Yeon LEE

IPC分类号： A61K38/48 ,  A61K35/16 ,  A61K35/19 ,  A61K33/06 ,  A61K31/196 ,  A61P19/08 ,  A61P19/04

摘要： The present disclosure relates to a pharmaceutical composition for preventing or treating musculoskeletal disease, which has the effect of proliferating endogenous cells in bone marrow. More specifically, the pharmaceutical composition of the present disclosure can be used for the treatment of musculoskeletal disease since it proliferates endogenous cells in bone marrow and enhances the functions thereof.

公开(公告)号：US20230235402A1

公开(公告)日：2023-07-27

申请号：US18007182

申请日：2021-07-02

申请人： SEOUL NATIONAL UNIVERSITY HOSPITAL ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  CHEONGJU UNIVERSITY INDUSTRY & ACADEMY COOPERATION FOUNDATION

发明人： Hyun Chul JO ,  Young-il HWANG ,  Jin-Hee KIM ,  Jin-Hong KIM ,  Jae-Hyung LEE ,  Hyun-Ju LIM ,  Ah-Young LEE ,  Seung Yeon LEE ,  Ji-Hye YEA ,  Yeasol KIM

IPC分类号： C12Q1/6883 ,  G01N33/68 ,  A61K38/17 ,  A61P21/00

CPC分类号： C12Q1/6883 ,  G01N33/6887 ,  A61K38/17 ,  A61P21/00 ,  C12Q2600/158 ,  G01N2800/10

摘要： A composition suitable for diagnosing a musculoskeletal disease and a composition suitable for preventing or treating a musculoskeletal disease are disclosed. The composition contains zinc finger protein with KRAB and SCAN domains 8 (Zkscan8) protein, which can be effectively used as an excellent biomarker for obtaining accurate information about the occurrence and progression stages of a musculoskeletal disease, specifically a tendon disease or a ligament disease. The compositions containing Zkscan8 can be effectively used for preventing or treating a musculoskeletal disease through Zkscan8 overexpression.