公开(公告)号：US11065340B2

公开(公告)日：2021-07-20

申请号：US16126798

申请日：2018-09-10

申请人： Serina Therapeutics, Inc.

发明人： Randall W. Moreadith ,  Michael D. Bentley ,  Zhihao Fang ,  Tacey Viegas

IPC分类号： A61K47/60 ,  A61K47/68 ,  A61K47/54 ,  A61K47/59

摘要： In the present disclosure, polymer conjugates, including polymer-antibody-drug conjugates (polymer ADCs) are described, as well as the use of such conjugates to treat human disease. The polymer conjugates can contain a large number of polymer-bound agents, thus effectively increasing the drug antibody ration (DAR) of the antibody significantly beyond the currently available technology. This may be of particular importance when antibodies to low density antigens are used as target antibodies. The described polymer-ADCs have improved pharmacokinetics and solubility relative to traditional ADCs. The linker between agent and the polymer can be tailored to provide release of toxin at the desired site and under the desired conditions within the tumor. An additional feature of the polymer-ADCs of the current disclosure is that a purification moiety can be attached to the polymer backbone to provide ease of purification of the polymer-ADCs.

公开(公告)号：US20170202972A1

公开(公告)日：2017-07-20

申请号：US15480122

申请日：2017-04-05

申请人： Serina Therapeutics, Inc.

发明人： Randall MOREADITH ,  Kunsang Yoon ,  Zhihao Fang ,  Rebecca Weimer ,  Bekir Dizman ,  Tacey Viegas ,  Michael David Bentley

IPC分类号： A61K47/48 ,  A61K31/4462 ,  A61K31/4535 ,  A61K9/00 ,  A61K31/7048 ,  A61K31/4745 ,  A61K31/381 ,  A61K31/4045 ,  A61K47/34

摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.

公开(公告)号：US20130177521A1

公开(公告)日：2013-07-11

申请号：US13774304

申请日：2013-02-22

申请人： Serina Therapeutics, Inc.

发明人： Randall Moreadith ,  Michael David Bentley ,  Kunsang Yoon ,  Zhihao Fang ,  Rebecca Weimer ,  Bekir Dizman ,  Tacey Viegas

IPC分类号： A61K47/48

CPC分类号： A61K47/48192 ,  A61K9/0019 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/4462 ,  A61K31/4535 ,  A61K31/4745 ,  A61K31/7048 ,  A61K47/542 ,  A61K47/60 ,  A61K47/61

摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.

摘要翻译： 本公开提供了包含聚合物和试剂的聚合物共轭物，所述试剂通过含有可水解部分的连接基与聚合物连接。

公开(公告)号：US20240108750A1

公开(公告)日：2024-04-04

申请号：US18387528

申请日：2023-11-07

申请人： Serina Therapeutics, Inc.

发明人： J Milton Harris ,  Michael Bentley ,  Tacey Viegas ,  Randall Moreadith ,  Robert J Sharpe ,  Kunsang Yoon ,  Zhihao Fang ,  Rebecca Weimer

IPC分类号： A61K47/69

CPC分类号： A61K47/6935

摘要： POZ-lipid conjugates and lipid nanoparticles (LNPs) including POZ-lipid conjugates used to facilitate delivery of an encapsulated payload. LNPs including POZ-lipid conjugates and a nucleic acid payload such as, but not limited to, mRNA or modified mRNA are disclosed. Such LNPs have no immunogenicity or reduced immunogenicity as compared to a corresponding LNP containing a PEG-lipid.

公开(公告)号：US11944618B2

公开(公告)日：2024-04-02

申请号：US17717666

申请日：2022-04-11

申请人： Serina Therapeutics, Inc.

发明人： Randall Moreadith ,  Kunsang Yoon ,  Zhihao Fang ,  Rebecca Weimer ,  Bekir Dizman ,  Tacey Viegas ,  Michael David Bentley

IPC分类号： A61K31/4745 ,  A61K9/00 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/4462 ,  A61K31/4535 ,  A61K31/7048 ,  A61K47/54 ,  A61K47/60 ,  A61K47/61

CPC分类号： A61K31/4745 ,  A61K9/0019 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/4462 ,  A61K31/4535 ,  A61K31/7048 ,  A61K47/542 ,  A61K47/60 ,  A61K47/61

摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent the agent linked to the polymer via a linking group containing a cleavable moiety.

公开(公告)号：US20220193243A1

公开(公告)日：2022-06-23

申请号：US17568042

申请日：2022-01-04

申请人： Serina Therapeutics, Inc.

发明人： J Milton Harris ,  Kunsang Yoon ,  Michael David Bentley ,  Zhihao Fang ,  Tacey Viegas

IPC分类号： A61K47/59 ,  C08G73/02 ,  A61P35/00 ,  A61K38/09

摘要： The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.

公开(公告)号：US11298350B2

公开(公告)日：2022-04-12

申请号：US16588761

申请日：2019-09-30

申请人： Serina Therapeutics, Inc.

发明人： Randall Moreadith ,  Kunsang Yoon ,  Zhihao Fang ,  Rebecca Weimer ,  Bekir Dizman ,  Tacey Viegas ,  Michael David Bentley

IPC分类号： A61K31/4745 ,  A61K47/60 ,  A61K47/54 ,  A61K47/61 ,  A61K31/381 ,  A61K31/4045 ,  A61K9/00 ,  A61K31/4462 ,  A61K31/4535 ,  A61K31/7048

摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.

公开(公告)号：US20190070301A1

公开(公告)日：2019-03-07

申请号：US16144358

申请日：2018-09-27

申请人： Serina Therapeutics, Inc.

发明人： J. Milton HARRIS ,  Kunsang Yoon ,  Michael David Bentley ,  Zhihao Fang ,  Tacey Viegas ,  Francesco Maria Veronese ,  Anna Mero

IPC分类号： A61K47/59 ,  C07K7/08 ,  A61K38/27 ,  A61K38/33 ,  A61K38/17 ,  A61K31/727 ,  A61K31/728 ,  A61K38/10 ,  A61K38/18 ,  A61K38/19 ,  A61K38/47 ,  C08G69/48 ,  C12N9/96 ,  C07K14/62 ,  C07K14/535 ,  C07K14/505 ,  C07K14/47 ,  A61K38/42

摘要： The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.

公开(公告)号：US20150079658A1

公开(公告)日：2015-03-19

申请号：US14550571

申请日：2014-11-21

申请人： Serina Therapeutics, Inc.

发明人： J Milton HARRIS ,  Michael David Bentley ,  Kunsang Yoon ,  Zhihao Fang ,  Francesco Maria Veronese ,  Tacey Viegas ,  Anna Mero

IPC分类号： C12N9/96 ,  C07K14/505 ,  C07K14/535 ,  C07K14/47 ,  C07K7/08 ,  C07K14/62

CPC分类号： A61K47/59 ,  A61K31/727 ,  A61K31/728 ,  A61K38/10 ,  A61K38/1719 ,  A61K38/1816 ,  A61K38/193 ,  A61K38/27 ,  A61K38/33 ,  A61K38/42 ,  A61K38/47 ,  C07K7/08 ,  C07K14/47 ,  C07K14/505 ,  C07K14/535 ,  C07K14/62 ,  C08G69/48 ,  C12N9/96 ,  C12Y302/01017

摘要： The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.

公开(公告)号：US20220249695A1

公开(公告)日：2022-08-11

申请号：US17665190

申请日：2022-02-04

申请人： Serina Therapeutics, Inc.

发明人： J Milton HARRIS ,  Michael Bentley ,  Tacey Viegas ,  Randall Moreadith ,  Robert J. Sharpe ,  Kunsang Yoon ,  Zhihao Fang ,  Rebecca Weimer

IPC分类号： A61K47/69

摘要： POZ-lipid conjugates and lipid nanoparticles (LNPs) including POZ-lipid conjugates used to facilitate delivery of an encapsulated payload. LNPs including POZ-lipid conjugates and a nucleic acid payload such as, but not limited to, mRNA or modified mRNA are disclosed. Such LNPs have no immunogenicity or reduced immunogenicity as compared to a corresponding LNP containing a PEG-lipid.