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公开(公告)号:US20120040474A1
公开(公告)日:2012-02-16
申请号:US13148289
申请日:2009-12-10
申请人: Robert J. Woods , Loretta Yang
发明人: Robert J. Woods , Loretta Yang
CPC分类号: C12Y302/01018 , C12N9/2402 , C12N9/80 , C12N9/82 , C12N15/1089 , C12Y302/01022 , C12Y302/01023 , C12Y302/01113 , C12Y302/01169 , C12Y305/01026 , C12Y305/01052
摘要: Provided are lectenz molecules, which are mutated carbohydrate processing enzyme enzymes that are catalytically inactive and that have had their substrate affinity increased by at least 1.2 fold. Further provided are methods for making and methods of using such lectenz. Additional mutated proteins following the lectenz approach are further provided.
摘要翻译: 提供的是分子,其是突变的碳水化合物加工酶,其催化无活性并且其底物亲和力增加至少1.2倍。 进一步提供了制作方法和使用这种教材的方法。 进一步提供了根据lectenz方法的其他突变蛋白。
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公开(公告)号:US20190211318A1
公开(公告)日:2019-07-11
申请号:US16306029
申请日:2017-06-09
申请人: Codexis, Inc.
CPC分类号: C12N9/2445 , C12N9/1051 , C12N15/70 , C12P19/14 , C12P19/18 , C12Y302/01021 , C12Y302/01169
摘要: The present invention provides engineered β-glucosidase (BGL) enzymes, polypeptides having BGL activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the enzymes, and methods of using the engineered BGL enzymes to make products with β-glucose linkages.
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公开(公告)号:US09809537B2
公开(公告)日:2017-11-07
申请号:US14424873
申请日:2013-08-29
发明人: Ernest J. McEachern , Jianyu Sun , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
IPC分类号: C07D207/12 , A61K31/40 , A61K31/428 , A61K31/4439 , C07D401/06 , C07D417/06 , C12N9/99 , C07D207/16
CPC分类号: C07D207/12 , A61K31/40 , A61K31/428 , A61K31/4439 , C07D207/16 , C07D401/06 , C07D417/06 , C12N9/99 , C12Y302/01169
摘要: The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号:US09718854B2
公开(公告)日:2017-08-01
申请号:US14008388
申请日:2012-03-20
申请人: Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
发明人: Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
IPC分类号: C07H19/24 , C07D513/04 , A61K31/429 , C12N9/99 , C12Q1/34 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , A61K31/7056
CPC分类号: C07H19/24 , A61K31/7056 , C07D513/04 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , C12N9/99 , C12Q1/34 , C12Y302/01169
摘要: The invention provides compounds of formula (I) with substituents as specified in claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.
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公开(公告)号:US09926612B2
公开(公告)日:2018-03-27
申请号:US13148289
申请日:2009-12-10
申请人: Robert J. Woods , Loretta Yang
发明人: Robert J. Woods , Loretta Yang
CPC分类号: C12Y302/01018 , C12N9/2402 , C12N9/80 , C12N9/82 , C12N15/1089 , C12Y302/01022 , C12Y302/01023 , C12Y302/01113 , C12Y302/01169 , C12Y305/01026 , C12Y305/01052
摘要: Provided are lectenz molecules, which are mutated carbohydrate processing enzymes that are catalytically inactive and that have had their substrate affinity increased by at least 1.2 fold. Further provided are methods for making and methods of using such lectenz. Additional mutated proteins following the lectenz approach are further provided.
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公开(公告)号:US20150274656A1
公开(公告)日:2015-10-01
申请号:US14424873
申请日:2013-08-29
发明人: Ernest J. McEachern , Jianyu Sun , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
IPC分类号: C07D207/12 , C07D207/16 , C07D417/06 , C07D401/06
CPC分类号: C07D207/12 , A61K31/40 , A61K31/428 , A61K31/4439 , C07D207/16 , C07D401/06 , C07D417/06 , C12N9/99 , C12Y302/01169
摘要: The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号:US20140088028A1
公开(公告)日:2014-03-27
申请号:US14008388
申请日:2012-03-20
申请人: Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
发明人: Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
IPC分类号: C07H19/24
CPC分类号: C07H19/24 , A61K31/7056 , C07D513/04 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , C12N9/99 , C12Q1/34 , C12Y302/01169
摘要: The invention provides compounds of formula (I) with substituents as specified in Claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.
摘要翻译: 本发明提供具有权利要求1所述取代基的式(I)化合物,用于选择性抑制糖苷酶,化合物的前药,以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的过度表达或O-GlcNac的积累有关的疾病和病症的方法。
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