公开(公告)号：US20150245992A1

公开(公告)日：2015-09-03

申请号：US14436235

申请日：2013-10-16

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Jiwen Zhang ,  Li Wu ,  Xianzhen Yin ,  Zhen Guo ,  Haiyan Li

IPC: A61K9/00 ,  G01N23/04 ,  A61K31/7052 ,  A61K31/40 ,  A61K47/32 ,  A61K31/192

CPC classification number: A61K9/0004 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/192 ,  A61K31/205 ,  A61K31/40 ,  A61K31/401 ,  A61K31/407 ,  A61K31/513 ,  A61K31/519 ,  A61K31/522 ,  A61K31/64 ,  A61K31/7052 ,  A61K31/7056 ,  A61K47/32 ,  G01N23/046

Abstract: Provided in the present invention is a pharmaceutic osmotic pump preparation comprising a tablet core, wherein the tablet core contains drugs (or pharmaceutically active ingredients) and materials forming a chamber structure; and a coating film coating the tablet core where a drug release hole is set; wherein when the pharmaceutic osmotic pump preparation releases drugs in water or an aqueous medium, the materials forming the chamber structure lead to the formation of a superfine chamber structure in the coating film, and the total volume of the superfine chamber structure Vb gradually increases over the releasing time, but the releasing rate R (or release amount A) of the pharmaceutically active ingredients is proportional to Vb. The osmotic pump preparation of the present invention is suitable for water-soluble drugs and water-insoluble drugs, and especially is suitable for the controlled release of low solubility drugs or pH dependent drugs.

Abstract translation: 本发明提供了包含片芯的药物渗透泵制剂，其中片芯含有药物（或药物活性成分）和形成室结构的材料; 以及涂布药片释放孔的片芯的涂膜; 其中当药物渗透泵制剂在水或水介质中释放药物时，形成室结构的材料导致在涂膜中形成超细腔室结构，并且超细腔室结构Vb的总体积逐渐增加 释放时间，但是药物活性成分的释放速度R（或释放量A）与Vb成比例。 本发明的渗透泵制剂适用于水溶性药物和水不溶性药物，特别适用于低溶解度药物或pH依赖性药物的控制释放。