公开(公告)号：US20250163065A1

公开(公告)日：2025-05-22

申请号：US18840522

申请日：2023-01-06

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Jianjun CHENG ,  Zhijie LIU ,  Tian HUA ,  Jianhang MAO ,  Ning ZHOU

IPC: C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61P25/18

Abstract: Provided are a pyrrolotriazinone compound represented by formula I or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising same, a preparation method therefor, and use thereof. The pyrrolotriazinone compound has agonistic activity on GPR139 receptor.

公开(公告)号：US20250109139A1

公开(公告)日：2025-04-03

申请号：US18729910

申请日：2023-01-19

Applicant: SHANGHAITECH UNIVERSITY ,  CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES

Inventor： Jianjun CHENG ,  Sheng WANG ,  Ruiquan LIU ,  Jianzhong QI ,  Luyu FAN ,  Jing YU

IPC: C07D493/04 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4985 ,  A61K31/53 ,  A61K31/538 ,  A61K31/541 ,  A61K31/55 ,  C07D487/04 ,  C07D519/00

Abstract: Disclosed are a tricyclic compound, and a preparation method therefor and the use thereof. The tricyclic compound has a structure as shown in formula I, and can be used for treating various mental diseases and neurodegenerative diseases such as schizophrenia, depression and Parkinson's disease.

公开(公告)号：US20240124456A1

公开(公告)日：2024-04-18

申请号：US18274889

申请日：2022-01-29

Applicant: SHANGHAITECH UNIVERSITY ,  CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES

Inventor： Jianjun CHENG ,  Sheng WANG ,  Huan WANG ,  Luyu FAN ,  Zhangcheng CHEN ,  Jing YU ,  Jianzhong QI ,  Fen NIE

IPC: C07D471/14 ,  A61P25/18 ,  A61P25/24 ,  C07D519/00

CPC classification number: C07D471/14 ,  A61P25/18 ,  A61P25/24 ,  C07D519/00 ,  C07B2200/13

Abstract: An aza-ergoline derivative and a preparation method therefor and an application thereof. The derivative has a structure as shown in formula (I). The aza-ergoline derivative has good affinity, agonistic activity or selectivity to a dopamine D2 receptor.

公开(公告)号：US20240076279A1

公开(公告)日：2024-03-07

申请号：US18271523

申请日：2021-12-17

Applicant: XUZHOU MEDICAL UNIVERSITY ,  SHANGHAITECH UNIVERSITY

Inventor： Dong GUO ,  Xudong CAO ,  Wenzhong YAN ,  Jianjun CHENG ,  Ying SUN ,  Limin SU ,  Ying REN ,  Ruoqi WANG ,  Haoran ZHANG ,  Haoxing YUAN

IPC: C07D401/12 ,  A61P13/12 ,  C07D223/16

CPC classification number: C07D401/12 ,  A61P13/12 ,  C07D223/16

Abstract: The present application relates to a novel benzoazepine compound, comprising a pharmaceutically acceptable salt thereof. The present application also provides a pharmaceutical composition comprising the compound and a pharmaceutically acceptable salt thereof. The present application relates to use of the compound and the composition in the prevention or treatment of diseases related to arginine vasopressin V1a receptor, arginine vasopressin V1b receptor, arginine vasopressin V2 receptor, sympathetic nervous system or renin-angiotensin-aldosterone system. The present application also provides a method for preventing and/or treating arginine vasopressin-related diseases.

公开(公告)号：US20250136601A1

公开(公告)日：2025-05-01

申请号：US18728450

申请日：2023-01-11

Applicant: SHANGHAITECH UNIVERSITY ,  CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES

Inventor： Jianjun CHENG ,  Sheng WANG ,  Huan WANG ,  Dongmei CAO ,  Jing YU ,  Wenwen DUAN ,  Licong HE

IPC: C07D471/14 ,  A61K31/4375 ,  A61K31/4985 ,  A61K31/5383 ,  A61K31/5517 ,  A61K31/554 ,  A61P25/24 ,  C07D498/14 ,  C07D513/14

Abstract: Disclosed are a cyclopiperidine compound, a preparation method therefor, and a use thereof. The cyclopiperidine compound of the present invention is represented by formula I′. The cyclopiperidine compound of the present invention has a better effect for suppressing depression and has good application prospects.