公开(公告)号：US11243191B2

公开(公告)日：2022-02-08

申请号：US16631508

申请日：2017-08-25

Applicant: SHIMADZU CORPORATION

Inventor： Taichi Tomono ,  Takayuki Iriki ,  Tomohiro Shagawa ,  Satoru Watanabe

IPC: G01N30/24 ,  G01N35/10 ,  G01N30/02 ,  G01N35/00

Abstract: An online HPLC dissolution test system includes a dissolution tester and a liquid chromatograph. An autosampler of the liquid chromatograph includes at least one flow vial, a sampling needle and an injection port. The flow vial is connected to the dissolution tester via a pipe and is for storing a sample solution supplied from the dissolution tester therein. The sampling needle is for collecting the sample solution by sucking from the flow vial. The injection port is for injecting the sample solution from the sampling needle into the analysis channel. The controller of the liquid chromatograph includes an immediate analyzing execution part configured to cause the autosampler to execute immediate analyzing operation for sucking the sample solution in the flow vial with the sampling needle and directly injecting the sample solution into the injection port when the sample solution is supplied from the dissolution tester to the flow vial.

公开(公告)号：US11543392B2

公开(公告)日：2023-01-03

申请号：US17535774

申请日：2021-11-26

Applicant: SHIMADZU CORPORATION

Inventor： Taichi Tomono ,  Takayuki Iriki ,  Tomohiro Shagawa ,  Satoru Watanabe

IPC: G01N30/24 ,  G01N35/10 ,  G01N35/00 ,  G01N13/00 ,  G01N30/02

Abstract: An online HPLC dissolution test system includes a dissolution tester and a liquid chromatograph. An autosampler of the liquid chromatograph includes at least one flow vial, a sampling needle and an injection port. the flow vial is connected to the dissolution tester via a pipe and is for storing a sample solution supplied from the dissolution tester therein. The sampling needle is for collecting the sample solution by sucking from the flow vial. The injection port is for injecting the sample solution from the sampling needle into the analysis channel. The controller of the liquid chromatograph includes an immediate analyzing execution part configured to cause the autosampler to execute immediate analyzing operation for sucking the sample solution in the flow vial with the sampling needle and directly injecting the sample solution into the injection port when the sample solution is supplied from the dissolution tester to the flow vial.

公开(公告)号：US11041833B2

公开(公告)日：2021-06-22

申请号：US16345685

申请日：2016-10-26

Applicant: Shimadzu Corporation

Inventor： Taichi Tomono

IPC: G01N30/16 ,  G01N35/10 ,  G01N13/00

Abstract: A flow-through vial includes: a columnar internal space for containing a liquid; a liquid introduction part provided in a lower portion of a side surface for guiding the liquid to the internal space in a direction oblique to a radial direction in a horizontal cross section of the internal space; a liquid discharge part provided in an upper portion of the side surface for guiding the liquid in the internal space to outside; and an upper surface sealing member for sealing an upper surface of the internal space, the upper surface sealing member being made of an elastic material which can be penetrated by a needle descending from above.