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公开(公告)号：US20190185802A1
公开(公告)日：2019-06-20
申请号：US16281287
申请日：2019-02-21
发明人： Yoichi Fujiyama , Yoh-ichi Tagawa
摘要： A cell culturing device has: a first culture chamber; a first introduction flow channel and a first discharge flow channel which are connected to the first culture chamber; a second culture chamber connected to a halfway part of the first introduction flow channel via a first porous membrane; and a second introduction flow channel and a second discharge flow channel which are connected to the second culture chamber. The first discharge flow channel is connected to the first culture chamber via a second porous membrane. The first introduction flow channel has a liquid collecting part between the first culture chamber and the second culture chamber.
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公开(公告)号：US10336987B2
公开(公告)日：2019-07-02
申请号：US15034031
申请日：2013-11-08
发明人： Yoichi Fujiyama , Yoh-ichi Tagawa
摘要： A device for culturing a liver tissue has a culture chamber to which at least two flow channels, which are at least for introducing and discharging a culture medium, are connected. A gel which serves as a cell scaffold material is housed in the culture chamber. A co-culture system containing an endothelial cell-derived cell, a hepatocyte-derived cell and a mesenchymal cell is co-cultured on the gel in such a way that the co-culture system has a tubular structure.
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公开(公告)号：US10301586B2
公开(公告)日：2019-05-28
申请号：US15302707
申请日：2014-04-14
发明人： Yoichi Fujiyama , Yoh-ichi Tagawa
摘要： A cell culturing device has: a first culture chamber; a first introduction flow channel and a first discharge flow channel which are connected to the first culture chamber; a second culture chamber connected to a halfway part of the first introduction flow channel via a first porous membrane; and a second introduction flow channel and a second discharge flow channel which are connected to the second culture chamber. The first discharge flow channel is connected to the first culture chamber via a second porous membrane. The first introduction flow channel has a liquid collecting part between the first culture chamber and the second culture chamber.
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公开(公告)号：US11549092B2
公开(公告)日：2023-01-10
申请号：US16689820
申请日：2019-11-20
发明人： Yoichi Fujiyama , Chikara Miyake , Yoh-ichi Tagawa
摘要： A cell evaluation device includes: a porous membrane having a first main face and a second main face; a first passage having a first passage portion facing a first area on which cells are placed in the first main face of the porous membrane; a second passage having a second passage portion facing a second area in the second main face of the porous membrane, the second area being positioned backside of the first area; and a first electrode provided in the first passage portion and a second electrode provided in the second passage portion, the first electrode and the second electrode being positioned across the first area and the second area. In the cell evaluation device, tight junctions are formed among the cells by cell cultivation. With the cell evaluation device, any increase in the electric resistance occurring due to the formation of the tight junctions can be easily measured.
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公开(公告)号：US11142735B2
公开(公告)日：2021-10-12
申请号：US16712238
申请日：2019-12-12
申请人： Shimadzu Corporation
摘要： To provide a cell treatment container, including: a first member having a flow path in which a cell suspension including a liquid and cells dispersed in the liquid flows through, the flow path formed on a surface of the first member; a second member arranged to face the surface of the first member; and a damming formed in one or both of the first member and the second member, in which the damming is provided with a protrusion part protruding from the first member into the flow path to form a gap for allowing the liquid in the cell suspension to pass through the gap and for damming up the cells in the cell suspension, and a pillar extending from the protrusion part at a first end and being joined to the second member at a second end.
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公开(公告)号：US10962450B2
公开(公告)日：2021-03-30
申请号：US16068896
申请日：2016-06-06
申请人： SHIMADZU CORPORATION
发明人： Ippei Takeuchi , Yoichi Fujiyama , Shinobu Kudoh , Koji Inoue
摘要： This specimen collection device has a channel through which a specimen can be drawn by capillarity. The channel has two channel sections that extend from the tip side to the base side and are connected at the tip side. One of the channel sections is connected to a base side specimen intake port, and the other terminates at a location prior to reaching the base end. An air hole is provided at this terminating location. The specimen collection device is equipped with an extraction unit for collecting a prescribed amount of the specimen. The extraction unit includes the two channel sections on the tip side of the air hole, and can be severed from the other sections of the device body of the specimen collection device via a severable section.
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7.发明申请公开(公告)号：US20170029759A1
公开(公告)日：2017-02-02
申请号：US15302707
申请日：2014-04-14
发明人： Yoichi Fujiyama , Yoh-ichi Tagawa
摘要： A cell culturing device has: a first culture chamber; a first introduction flow channel and a first discharge flow channel which are connected to the first culture chamber; a second culture chamber connected to a halfway part of the first introduction flow channel via a first porous membrane; and a second introduction flow channel and a second discharge flow channel which are connected to the second culture chamber. The first discharge flow channel is connected to the first culture chamber via a second porous membrane. The first introduction flow channel has a liquid collecting part between the first culture chamber and the second culture chamber.
摘要翻译： 细胞培养装置具有：第一培养室; 与第一培养室连接的第一引入流路和第一排出流路; 第二培养室，经由第一多孔膜连接到第一引入流动通道的中间部分; 以及与第二培养室连接的第二导入流路和第二排出流路。 第一排出流路通过第二多孔膜与第一培养室连接。 第一引入流路在第一培养室和第二培养室之间具有液体收集部。
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