公开(公告)号：US20180252730A1

公开(公告)日：2018-09-06

申请号：US15580855

申请日：2016-06-10

Applicant: Kanazawa University ,  Shiseido Company. Ltd

Inventor： Takashi Wada ,  Kengo FURUICHI ,  Norihiro SAKAI ,  Yasunori IWATA ,  Akinori HARA ,  Yusuke NAKADE ,  Kenji HAMASE ,  Yurika MIYOSHI ,  Maiko NAKANE ,  Masashi MITA

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/6806 ,  G01N2800/347

Abstract: The present invention addresses the problem of developing an analytical method which makes it possible to diagnose early or mild renal disorders. The method is based on calculating a disease-state index value for renal disorders on the basis of the quantities of D-form and/or L-form amino acids, from feces or intestinal content. By comparing the disease-state index value with a threshold value determined from the disease-state index values of a renal failure patient group and a healthy subject group, it is possible to diagnose a mild renal disorder patient group.

公开(公告)号：US20200002322A1

公开(公告)日：2020-01-02

申请号：US16490713

申请日：2018-03-02

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Kenji HAMASE ,  Takeyuki AKITA ,  Masashi MITA

IPC: C07D413/12 ,  C07D271/12 ,  G01N30/06 ,  G01N30/74

Abstract: The object of the present invention is to develop a reagent for optical resolution for the analysis of chiral amino acids wherein quenching is not exhibited. This object is achieved by providing a novel compound for optical resolution wherein quenching is not exhibited. The present invention relates to a novel compound, a reagent for optical resolution comprising the novel compound, a method for optically resolution comprising a step of reacting the novel compound, and optical isomers obtained by reacting the novel compound with amino acids.

公开(公告)号：US20160039743A1

公开(公告)日：2016-02-11

申请号：US14918743

申请日：2015-10-21

Applicant: SHISEIDO COMPANY, LTD. ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Masashi MITA ,  Kenji HAMASE ,  Tsubasa OYAMA

IPC: C07C227/36

CPC classification number: C07C227/36 ,  C07C227/34 ,  C07D215/22 ,  C07D401/12 ,  C07C229/08

Abstract: Disclosed is a compound represented by chemical formula (1): or chemical formula (2):

公开(公告)号：US20190056323A1

公开(公告)日：2019-02-21

申请号：US15770593

申请日：2016-11-04

Applicant: SHISEIDO COMPANY, LTD. ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Masashi MITA ,  Eiichi NEGISHI ,  Kazuhiko Mibayashi ,  Kenji HAMASE

IPC: G01N21/64 ,  G01N30/74 ,  G01N33/50 ,  G01N30/46

Abstract: [Problem]To provide a fluorescence detection apparatus that is capable of simultaneously detecting a plurality of analyte components contained at different concentrations with a wide measurement range.[Solution]A fluorescence detection apparatus 100 includes a cell 110 into which an analyte of a sample is introduced, a light source 130 that irradiates excitation light on the analyte in the cell; a first detector 52 that detects fluorescence generated from the analyte after the excitation light has been irradiated on the analyte, and a second detector 53 that detects the fluorescence generated from the analyte after the excitation light has been irradiated on the analyte. The second detector detects the fluorescence with a measurement range that is different from the measurement range of the first detector, and the first detector and second detector detect the fluorescence simultaneously.

公开(公告)号：US20150065716A1

公开(公告)日：2015-03-05

申请号：US14472920

申请日：2014-08-29

Applicant: SHISEIDO COMPANY, LTD. ,  Kyushu University, National University Corporation

Inventor： Masashi MITA ,  Kenji HAMASE ,  Tsubasa OYAMA

IPC: C07D215/22 ,  C07C227/34 ,  C07D401/12

CPC classification number: C07C227/36 ,  C07C227/34 ,  C07D215/22 ,  C07D401/12 ,  C07C229/08

Abstract: Disclosed is a compound represented by chemical formula (1): or chemical formula (2):

Abstract translation: 公开了由化学式（1）表示的化合物：或化学式（2）：

公开(公告)号：US20180045690A1

公开(公告)日：2018-02-15

申请号：US15555862

申请日：2016-05-10

Applicant: SHISEIDO COMPANY, LTD. ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Kenji HAMASE ,  Shoto ISHIGO ,  Yurika MIYOSHI ,  Tadashi UEDA ,  Masashi MITA

IPC: G01N30/06 ,  G01N33/68 ,  G01N30/78 ,  G01N30/72 ,  G01N30/74

CPC classification number: G01N30/06 ,  G01N30/7233 ,  G01N30/74 ,  G01N30/78 ,  G01N30/8679 ,  G01N30/88 ,  G01N33/68 ,  G01N2030/067 ,  G01N2030/8818 ,  G01N2030/8877 ,  G01N2560/00

Abstract: A chiral analysis method of a bound amino acid includes a step of hydrolyzing a bound amino acid using a deuterium chloride-deuterium oxide solution and/or deuterium oxide; a step of separating, by chiral separation, a D-form and an L-form of an amino acid generated by the hydrolyzation; a step of generating fragments from the separated amino acid; and a step of selecting and analyzing a predetermined fragment that contains an α carbon and does not contain a side chain from the generated fragments, by mass spectrometry.

公开(公告)号：US20190339281A1

公开(公告)日：2019-11-07

申请号：US16231381

申请日：2018-12-21

Applicant: Shiseido Company, Ltd.

Inventor： Kenji HAMASE ,  Yurika MIYOSHI ,  Masashi MITA

IPC: G01N33/68

Abstract: The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

公开(公告)号：US20150064797A1

公开(公告)日：2015-03-05

申请号：US14472982

申请日：2014-08-29

Applicant: SHISEIDO COMPANY, LTD. ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Masashi MITA ,  Kenji HAMASE

IPC: G01N31/00

CPC classification number: G01N31/005 ,  G01N33/6815 ,  Y10T436/182

Abstract: A method for quantitatively analyzing cysteine and cysteine includes a first step of adding a methyl-sulfurating agent to a sample that includes cysteine and cystine to obtain a methyl-sulfurated cysteine, a second step of adding a derivatizing agent to the methyl-sulfurated cysteine and the cystine to obtain a cysteine derivative and a cystine derivative, respectively, and a third step of quantifying the cysteine derivative and the cystine derivative.

Abstract translation: 用于定量分析半胱氨酸和半胱氨酸的方法包括向包含半胱氨酸和胱氨酸的样品中加入甲基硫化剂以获得甲基 - 硫化半胱氨酸的第一步骤，向甲基 - 硫化半胱氨酸添加衍生化试剂的第二步骤和 分别得到半胱氨酸衍生物和胱氨酸衍生物的胱氨酸，第三步是定量半胱氨酸衍生物和胱氨酸衍生物。