公开(公告)号：US20140057979A1

公开(公告)日：2014-02-27

申请号：US14053623

申请日：2013-10-15

Applicant: Shiseido Company, Ltd.

Inventor： Yoko Gozu ,  Shinichiro Haze

IPC: A61K31/336 ,  C07C69/78 ,  C07C229/38 ,  C07C229/60

CPC classification number: A61K31/336 ,  A61K31/216 ,  A61K31/618 ,  C07C69/78 ,  C07C229/38 ,  C07C229/60

Abstract: The present invention provides substances that can be used in a broad range of applications and effectively regulate clock gene expression.Provided is a clock gene expression regulating agent comprising, as an active ingredient, one or more selected from the group consisting of caryophyllene oxide and compounds represented by the following structural formula: wherein X is CH3, NH2 or NHCH3.

Abstract translation: 本发明提供可用于广泛应用并有效调节时钟基因表达的物质。 本发明提供一种时钟基因表达调节剂，其包含选自由以下结构式表示的石竹烯氧化物和其中X为CH 3，NH 2或NHCH 3的化合物作为活性成分的一种或多种。

公开(公告)号：US09827187B2

公开(公告)日：2017-11-28

申请号：US14419715

申请日：2013-03-29

Applicant: Shiseido Company, Ltd.

Inventor： Yoko Gozu ,  Shinichiro Haze

IPC: A61K36/00 ,  A61K8/97 ,  A61Q19/00 ,  A61K31/235 ,  A61K31/245 ,  A61K36/23 ,  A61K36/53 ,  A61K36/73 ,  A61K8/44 ,  A61K8/92 ,  A61K36/758 ,  A61K36/14 ,  A61K36/185 ,  A61K36/67 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K9/06 ,  A61K47/44 ,  A61K9/20 ,  A61K9/50 ,  A61K8/37 ,  A61K8/41 ,  A61K8/49

CPC classification number: A61K8/97 ,  A61K8/37 ,  A61K8/411 ,  A61K8/44 ,  A61K8/445 ,  A61K8/4926 ,  A61K8/922 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/2018 ,  A61K9/2068 ,  A61K9/5042 ,  A61K31/235 ,  A61K31/245 ,  A61K36/14 ,  A61K36/185 ,  A61K36/23 ,  A61K36/53 ,  A61K36/67 ,  A61K36/73 ,  A61K36/758 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K2800/70 ,  A61K2800/74 ,  A61Q19/00 ,  A61Q19/007 ,  A61K2300/00

Abstract: The present invention provides a novel substance that promotes expression of filaggrin gene involved in improvement of the moisture retention function of skin. The inventors of the present invention found that expression of filaggrin gene fluctuates rhythmically over a roughly 24 hour cycle, screened candidate substances based on the time at which expression reaches a maximum following addition of the candidate substance, and identified zanthoxylum extract, 3-(1′-piperidine)propionic acid, geranium oil, cypress oil, rose oil, galvanum oil, pepper oil, basil oil, methyl-o-toluate, methyl anthranilate and dimethyl anthranilate as filaggrin gene expression promoting agents.

公开(公告)号：US20150190336A1

公开(公告)日：2015-07-09

申请号：US14419715

申请日：2013-03-29

Applicant: Shiseido Company, Ltd.

Inventor： Yoko Gozu ,  Shinichiro Haze

IPC: A61K8/97 ,  A61Q19/00 ,  A61K8/49 ,  A61K8/37 ,  A61K8/41

CPC classification number: A61K8/97 ,  A61K8/37 ,  A61K8/411 ,  A61K8/44 ,  A61K8/445 ,  A61K8/4926 ,  A61K8/922 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/2018 ,  A61K9/2068 ,  A61K9/5042 ,  A61K31/235 ,  A61K31/245 ,  A61K36/14 ,  A61K36/185 ,  A61K36/23 ,  A61K36/53 ,  A61K36/67 ,  A61K36/73 ,  A61K36/758 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K2800/70 ,  A61K2800/74 ,  A61Q19/00 ,  A61Q19/007 ,  A61K2300/00

Abstract: The present invention provides a novel substance that promotes expression of filaggrin gene involved in improvement of the moisture retention function of skin. The inventors of the present invention found that expression of filaggrin gene fluctuates rhythmically over a roughly 24 hour cycle, screened candidate substances based on the time at which expression reaches a maximum following addition of the candidate substance, and identified zanthoxylum extract, 3-(1′-piperidine)propionic acid, geranium oil, cypress oil, rose oil, galvanum oil, pepper oil, basil oil, methyl-o-toluate, methyl anthranilate and dimethyl anthranilate as filaggrin gene expression promoting agents.

Abstract translation: 本发明提供促进丝胶蛋白基因表达的新型物质，其涉及改善皮肤的保湿功能。 本发明的发明人发现丝聚蛋白基因的表达在大约24小时周期内有节奏地波动，基于候选物质添加后表达达到最大值的时间筛选候选物质，并鉴定了花椒提取物3-（1 β-哌啶）丙酸，天竺葵油，柏油，玫瑰油，原油，胡椒油，罗勒油，甲基邻甲苯甲酸酯，邻氨基苯甲酸甲酯和邻氨基苯甲酸二甲酯作为丝胶蛋白基因表达促进剂。

公开(公告)号：US20150072031A1

公开(公告)日：2015-03-12

申请号：US14540248

申请日：2014-11-13

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Keiko Mori ,  Shinichiro Haze ,  Yoko Gozu ,  Atsushi Joichi

IPC: A61K36/537 ,  A61K31/085 ,  A61K36/534 ,  A61K36/14 ,  A61K8/34 ,  A23L1/30 ,  A61K8/97 ,  A61Q19/00 ,  A61Q5/02 ,  A61Q19/10 ,  A61L9/16 ,  A61L9/013 ,  A61K31/045 ,  A61K8/33

CPC classification number: A61K36/537 ,  A23G3/48 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/00 ,  A61K8/33 ,  A61K8/34 ,  A61K8/342 ,  A61K8/97 ,  A61K8/9789 ,  A61K31/045 ,  A61K31/085 ,  A61K36/14 ,  A61K36/185 ,  A61K36/534 ,  A61K2800/242 ,  A61L9/013 ,  A61L9/16 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  A61Q19/10 ,  A23V2200/318 ,  A23V2250/21

Abstract: Disclosed here is a method for elevating skin temperature comprising administering to a subject in need thereof a composition comprising an effective amount of one or more compounds selected from the group consisting of dihydro-β-ionol and 4-methoxystyrene. Also disclosed is a method for elevating skin temperature comprising administering to a subject in need thereof a composition comprising an effective amount of one or more compounds selected from the group consisting of dihydro-β-ionol, 4-methoxystyrene, clary sage extract, Japanese peppermint extract, juniper berry extract, and geraniol.

Abstract translation: 这里公开了一种用于升高皮肤温度的方法，其包括向有需要的受试者施用包含有效量的一种或多种选自二氢 - 苯乙醇和4-甲氧基苯乙烯的化合物的组合物。 还公开了一种用于升高皮肤温度的方法，其包括向有需要的受试者施用包含有效量的一种或多种选自二氢 - 苯乙醇，4-甲氧基苯乙烯，谷类精液提取物，日本 薄荷提取物，杜松子提取物和香叶醇。