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公开(公告)号：US20220378785A1
公开(公告)日：2022-12-01
申请号：US17562933
申请日：2021-12-27
IPC分类号： A61K31/505 , C07D239/48 , C07D239/42
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
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公开(公告)号：US10689351B2
公开(公告)日：2020-06-23
申请号：US16452691
申请日：2019-06-26
发明人： Hon-Wah Man , Mohit Atul Kothare
IPC分类号： C07D239/48 , C07B59/00
摘要： Provided herein are isotopologues of Compound A, which are enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and methods of using such compounds are also provided.
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公开(公告)号：US11241430B2
公开(公告)日：2022-02-08
申请号：US16679592
申请日：2019-11-11
IPC分类号： A61K31/505 , C07D239/48 , C07D239/42
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
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公开(公告)号：US09079900B2
公开(公告)日：2015-07-14
申请号：US14174896
申请日：2014-02-07
发明人： Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Gingsee Lee , Garrick Packard , Jingjing Zhao , Patrick Anthony Jokiel , Deborah Mortensen , Jennifer Riggs , Juan Antonio Gamboa , Marie Georges Beauchamps , Matthew Michael Kreilein , Mohit Atul Kothare , Sophie Perrin-Ninkovic , Philip Pye , William Wei-Hwa Leong , Jan Elsner , Anusuya Choudhury
IPC分类号： A61K31/497 , C07D241/00 , C07D471/04 , C07D487/04 , C07D498/14 , C07D519/00
CPC分类号： C07D471/04 , C07D241/20 , C07D487/04 , C07D498/14 , C07D519/00
摘要： Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.
摘要翻译： 本文提供了制备具有以下结构的杂芳基化合物的方法：其中R 1 -R 4如本文所定义。 杂芳基化合物可用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经障碍，年龄相关疾病或心血管疾病。
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公开(公告)号：US10975039B2
公开(公告)日：2021-04-13
申请号：US16871143
申请日：2020-05-11
发明人： Hon-Wah Man , Mohit Atul Kothare
IPC分类号： C07D239/48 , C07B59/00
摘要： Provided herein are isotopologues of Compound A, which are enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and methods of using such compounds are also provided.
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公开(公告)号：US10517873B2
公开(公告)日：2019-12-31
申请号：US16266793
申请日：2019-02-04
发明人： Marie Georges Beauchamps , Antonio Christian Ferretti , Robert Hilgraf , Mohit Atul Kothare , Hon-Wah Man , Mark A. Nagy , Kelvin Hin-Yeong Yong , Nanfei Zou
IPC分类号： C07D239/42 , A61K31/505 , C07D239/48
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
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公开(公告)号：US20180028534A1
公开(公告)日：2018-02-01
申请号：US15727659
申请日：2017-10-09
IPC分类号： A61K31/505 , C07D239/42 , C07D239/48
CPC分类号： A61K31/505 , C07D239/42 , C07D239/48
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
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8.发明授权Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use 有权固体形式的2-（叔丁基氨基）-4 - （（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-甲酰胺及其使用方法公开(公告)号：US09365524B2
公开(公告)日：2016-06-14
申请号：US14608314
申请日：2015-01-29
发明人： Hon-Wah Man , Jean Xu , Marie Georges Beauchamps , Mohit Atul Kothare , Nanfei Zou , Ying Li , Lianfeng Huang , Daozhong Zou
IPC分类号： A61K31/505 , C07D239/48 , C07D239/42
CPC分类号： A61K31/505 , C07D239/42 , C07D239/48
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
摘要翻译： 本文提供了与2-（叔丁基氨基）-4 - （（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-甲酰胺相关的制剂，方法，固体形式和使用方法。
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公开(公告)号：US20200078359A1
公开(公告)日：2020-03-12
申请号：US16679592
申请日：2019-11-11
IPC分类号： A61K31/505 , C07D239/42 , C07D239/48
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
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公开(公告)号：US10226461B2
公开(公告)日：2019-03-12
申请号：US15727659
申请日：2017-10-09
IPC分类号： C07D239/42 , A61K31/505 , C07D239/48
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
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