公开(公告)号：US10758905B2

公开(公告)日：2020-09-01

申请号：US15775717

申请日：2016-11-11

Applicant: Singapore University of Technology and Design

Inventor： Ye Ai ,  David John Collins

IPC: B01L3/00 ,  H01L41/187

Abstract: The present invention relates to the use of acoustic waves for the manipulation and sorting of particles and cells. In an embodiment, there is provided a microfluidic device for manipulating a particle in a fluid suspension, the device comprising: (a) a substrate; (b) a channel defined in the substrate, the channel having an inlet for receiving the fluid suspension and an outlet for discharging the fluid suspension; and (c) an acoustic source configured to deliver a travelling surface acoustic wave transverse the flow of the fluid suspension in the channel, wherein the acoustic source is an interdigital transducer (IDT), the IDT comprises a plurality of concentric circular arcs having a tapered end directed at the channel, and the tapered end has an aperture of between 4 μm and 150 μm. In an alternative embodiment, the device comprises a second channel disposed intermediate the first channel and the acoustic source wherein the first and second channels are connected by a pumping channel.

公开(公告)号：US20210129149A1

公开(公告)日：2021-05-06

申请号：US17074689

申请日：2020-10-20

Applicant: SINGAPORE UNIVERSITY OF TECHNOLOGY AND DESIGN

Inventor： Ye Ai ,  David Collins ,  Richard O'Rorke

IPC: B01L3/00

Abstract: A microfluidic device includes a substrate and a microfluidic channel, wherein the microfluidic channel is configured to form a fluid pathway for allowing a fluid sample comprising particles to flow along the microfluidic channel; and a single transducer provided on the substrate for producing an acoustic travelling wave that propagates on the substrate surface towards an interaction region associated with the microfluidic channel as the fluid sample is flowing through the microfluidic channel. The microfluidic channel comprises three channel portions having three orientations, respectively, that are different from each other with respect to a direction of the propagation path of the travelling acoustic wave in the interaction region, the three channel portions arranged to produce fluid wavefronts based on substrate-propagated acoustic waves such that the fluid wavefronts and subsequent substrate-propagated acoustic wavefronts interfere with one another to generate periodic acoustic force fields in the fluid sample for manipulating the particles.

公开(公告)号：US20190160463A1

公开(公告)日：2019-05-30

申请号：US16091813

申请日：2017-07-19

Applicant: SINGAPORE UNIVERSITY OF TECHNOLOGY AND DESIGN

Inventor： Ye Ai ,  Zhichao Ma

IPC: B01L3/00

Abstract: The present invention relates to the manipulation and, more particularly, to the sorting of particles. Still more particularly, the present invention relates to the use of acoustic waves, including surface acoustic waves, for the manipulation and sorting of particles. In an example, the present invention may be used for the sorting of cells. In an aspect of the invention, there is provided a device for manipulating a particle in a fluid suspension, the device comprising: (a) a substrate having a surface; (b) an acoustic source configured to generate and deliver an acoustic wave within a region of the substrate surface; and (c) a pillar disposed on the surface of the substrate and the pillar is configured to receive a channel, the channel configured to receive the fluid suspension, wherein the acoustic wave delivered within the region of the substrate surface is delivered to the fluid suspension in the channel through the pillar. A method using the device of the invention is also disclosed.

公开(公告)号：US20180369816A1

公开(公告)日：2018-12-27

申请号：US15775717

申请日：2016-11-11

Applicant: Singapore University of Technology and Design

Inventor： Ye Ai ,  David John Collins

IPC: B01L3/00 ,  H01L41/187

CPC classification number: B01L3/502761 ,  B01L3/502776 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0436 ,  H01L41/187

Abstract: The present invention relates to the use of acoustic waves for the manipulation and sorting of particles and cells. In an embodiment, there is provided a microfluidic device for manipulating a particle in a fluid suspension, the device comprising: (a) a substrate; (b) a channel defined in the substrate, the channel having an inlet for receiving the fluid suspension and an outlet for discharging the fluid suspension; and (c) an acoustic source configured to deliver a travelling surface acoustic wave transverse the flow of the fluid suspension in the channel, wherein the acoustic source is an interdigital transducer (IDT), the IDT comprises a plurality of concentric circular arcs having a tapered end directed at the channel, and the tapered end has an aperture of between 4 μm and 150 μm. In an alternative embodiment, the device comprises a second channel disposed intermediate the first channel and the acoustic source wherein the first and second channels are connected by a pumping channel.