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公开(公告)号：US09896688B2
公开(公告)日：2018-02-20
申请号：US14769361
申请日：2014-02-20
发明人： Wonsuk Chang , Erin N. Guidry , Matthew G. Stanton , Daniel Zewge
CPC分类号： C12N15/113 , C07H19/10 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/319
摘要： The present invention relates to RNAi molecules, and compositions thereof, comprising a 2′ internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5′ end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5′ modified nucleotides that comprise, among other potential modifications, a 2′ internucleoside linkage. The invention further relates to 5′ modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.
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2.发明授权公开(公告)号：US10738308B2
公开(公告)日：2020-08-11
申请号：US15863578
申请日：2018-01-05
发明人： Wonsuk Chang , Erin N. Guidry , Matthew G. Stanton , Daniel Zewge
摘要： The present invention relates to RNAi molecules, and compositions thereof, comprising a 2′ internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5′ end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5′ modified nucleotides that comprise, among other potential modifications, a 2′ internucleoside linkage. The invention further relates to 5′ modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.
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3.发明申请公开(公告)号：US20180265869A1
公开(公告)日：2018-09-20
申请号：US15863578
申请日：2018-01-05
发明人： Wonsuk Chang , Erin N. Guidry , Matthew G. Stanton , Daniel Zewge
摘要： The present invention relates to RNAi molecules, and compositions thereof, comprising a 2′ internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5′ end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5′ modified nucleotides that comprise, among other potential modifications, a 2′ internucleoside linkage. The invention further relates to 5′ modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.
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4.发明申请SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE 有权含有2'核苷酸连接的短链核酸（siNA）分子公开(公告)号：US20160068837A1
公开(公告)日：2016-03-10
申请号：US14769361
申请日：2014-02-20
发明人： Wonsuk Chang , Erin N. Guidry , Matthew G. Stanton , Daniel Zewge
IPC分类号： C12N15/113 , C07H19/10
CPC分类号： C12N15/113 , C07H19/10 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/319
摘要： The present invention relates to RNAi molecules, and compositions thereof, comprising a 2′ internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5′ end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5′ modified nucleotides that comprise, among other potential modifications, a 2′ internucleoside linkage. The invention further relates to 5′ modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.
摘要翻译： 本发明涉及RNAi分子及其组合物，其包含连接位于第1位核苷酸和反义链5'末端第2位核苷酸的2'核苷间键。 具体地，本发明涉及能够介导包含5'修饰的核苷酸的RNA干扰的单链和双链短干扰核酸（siNA）分子，其包括2'核苷间键的其它潜在修饰。 本发明还涉及用作产生本发明的RNAi分子的试剂的5'修饰的核苷酸和使用所公开的RNAi分子的方法。
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