公开(公告)号：US20220389047A1

公开(公告)日：2022-12-08

申请号：US17775864

申请日：2020-11-13

Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION ,  SOMAR CORPORATION

Inventor： Hirohiko ISE ,  Saori MATSUO

IPC: C07H15/26 ,  A61P17/02

Abstract: An O-GlcNAcylated protein-like substance having an N-acetylglucosamine unit, and at least one unit selected from the group consisting of a carboxy group-containing radically polymerizable unit, a styrene unit, a polyethylenimine unit, a poly-L-lysine unit, and a biotin unit; and a fibrosis therapeutic drug containing the O-GlcNAcylated protein-like substance.

公开(公告)号：US20170095564A1

公开(公告)日：2017-04-06

申请号：US15312507

申请日：2015-05-19

Applicant: SOMAR CORPORATION

Inventor： Hirohiko ISE

IPC: A61B10/00 ,  C08F12/26 ,  A61K49/00 ,  A61K41/00

CPC classification number: A61K49/0052 ,  A61K41/00 ,  A61K47/36 ,  A61K47/50 ,  A61K47/542 ,  A61K47/545 ,  A61K47/549 ,  A61K47/61 ,  A61K47/6905 ,  A61K49/00 ,  A61K49/0043 ,  A61K49/0076 ,  C08F12/26

Abstract: An N-acetylglucosamine sugar chain group-containing compound which can easily reach cells/sites on which a vimentin and/or desmin protein(s) is/are exposed, which compound has excellent affinity to N-acetylglucosamine sugar chain-recognizing proteins; a drug delivery carrier compound comprising the compound: a preparation using the drug delivery earner compound; and a drug delivery system; are provided. These are an N-acetylglucosamine sugar chain group-containing compound having a weight average molecular weight within the range of 15,000 to 100,000; a drug delivery carrier compound comprising the compound; a preparation using the drug delivery carrier compound; and a drug delivery system.