公开(公告)号：US12023493B2

公开(公告)日：2024-07-02

申请号：US17606427

申请日：2020-01-09

申请人： SOOCHOW UNIVERSITY

发明人： Yaobo Liu ,  Dan Yang ,  Wei Yang ,  Kai Zhou ,  Wei Wei ,  Hui Zhang

IPC分类号： A61N1/05 ,  A61B5/00 ,  A61B5/389 ,  A61N1/36

CPC分类号： A61N1/36003 ,  A61B5/389 ,  A61B5/4848 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36062 ,  A61N1/36153 ,  A61N1/36171 ,  A61B2503/40 ,  A61B2503/42

摘要： A closed-loop spinal cord electrical stimulation system includes a spinal epidural electrical stimulation electrode, a low limb electrical stimulation electrode, a closed-loop electrical stimulator and a controller. The spinal epidural electrical stimulation electrode, the low limb electrical stimulation electrode and the controller are electrically connected to the closed-loop electrical stimulator respectively. The spinal epidural electrical stimulation electrode is used for applying a first electrical stimulation to the spinal epidural site, and the low limb electrical stimulation electrode is used for applying a second electrical stimulation to a low limb. The voltage of the first electric stimulation is 400-600 mV, the voltage of the second electric stimulation is 1 V-1.5 V, and the stimulation frequency of the both is 10-20 Hz. The stimulation system can send electrophysiological signals similar to sensorimotor neural circuitry to the subject with spinal cord injury, and can activate and remodel the neural circuit.