公开(公告)号：US09378548B2

公开(公告)日：2016-06-28

申请号：US14359722

申请日：2012-11-29

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Junyu Guo ,  Wilburn E. Reddick

IPC: G06K9/00 ,  G06T7/00 ,  G06T5/00 ,  G01R33/50 ,  G01R33/483

CPC classification number: G06T7/0012 ,  A61B5/055 ,  A61B5/7225 ,  A61B5/7271 ,  G01R33/4835 ,  G01R33/50 ,  G06T5/00 ,  G06T5/002 ,  G06T2207/10088 ,  G06T2207/20024

Abstract: Apparatus, methods, and other embodiments associated with the spectral analysis of T2 spectral data are described. One example magnetic resonance imaging (MRI) method includes accessing a data set comprising T2 spectral data associated with a magnetic resonance imaging (MRI) signal received from an object. The T2 spectral data is decomposed with multi-exponential functions to determine T2 spectra. The T2 spectral amplitude is regularized with a regularized constant. The regularized constant is sufficiently large to smooth the T2 spectra so adjacent pixels of the T2 spectral data have similar characteristics. The T2 spectral data is weighted so that the regularization is uniformly weighted for the spectral amplitudes. The T2 spectra is partitioned into intervals corresponding to myelin water fraction (MWF), tissue water fraction (TWF), Long T2 water fraction (LWF), and cerebrospinal fluid fraction (CSF). Parametric maps are generated based, at least in part, on the T2 spectral data.

Abstract translation: 描述了与T2光谱数据的光谱分析相关联的装置，方法和其它实施例。 一个例子磁共振成像（MRI）方法包括访问包括与从对象接收的磁共振成像（MRI）信号相关联的T2光谱数据的数据集。 T2光谱数据用多指数函数分解，以确定T2光谱。 T2频谱振幅用正则化常数正则化。 正则化常数足够大以平滑T2光谱，因此T2光谱数据的相邻像素具有相似的特性。 T2频谱数据被加权，使得正则化对于频谱幅度被均匀加权。 T2光谱分为对应于髓磷脂水分（MWF），组织水分（TWF），Long T2水分（LWF）和脑脊液分数（CSF）的间隔。 至少部分地基于T2光谱数据生成参数图。

公开(公告)号：US20180329007A1

公开(公告)日：2018-11-15

申请号：US15774839

申请日：2016-11-09

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Junyu Guo ,  Wilburn E. Reddick

IPC: G01R33/485 ,  G01R33/46

CPC classification number: G01R33/485 ,  G01R33/4616 ,  G01R33/4838

Abstract: Systems, methods, and other embodiments associated with phase cycled magnetic resonance spectroscopic imaging (PCSI). According to one embodiment, a method includes applying an excitation radio frequency (RF) pulse having a low flip angle to a sample. The method further includes adjusting the phase of the RF to sweep through a frequency range based, at least in part, on PCSI. Sampling is then performed in the frequency range. The method also includes receiving a set of data based, at least in part, on the sampling in the frequency range.

公开(公告)号：US09953418B2

公开(公告)日：2018-04-24

申请号：US15166440

申请日：2016-05-27

Applicant: St. Jude Children's Research Hospital

Inventor： Junyu Guo ,  Wilburn E. Reddick

IPC: G06K9/00 ,  G06T7/00 ,  G06T5/00 ,  G01R33/50 ,  A61B5/055 ,  A61B5/00 ,  G01R33/483

CPC classification number: G06T7/0012 ,  A61B5/055 ,  A61B5/7225 ,  A61B5/7271 ,  G01R33/4835 ,  G01R33/50 ,  G06T5/00 ,  G06T5/002 ,  G06T2207/10088 ,  G06T2207/20024

Abstract: Apparatus, methods, and other embodiments associated with the spectral analysis of T2 spectral data are described. One example magnetic resonance imaging (MRI) method includes accessing a data set comprising T2 spectral data associated with a magnetic resonance imaging (MRI) signal received from an object. The method also includes decomposing the T2 spectral data with multi-exponential functions to determine T2 spectra corresponding to the T2 spectral data. The T2 spectra are portioned into a plurality of intervals defined by the T2 spectral data acquired in a predetermined time period.

公开(公告)号：US20140270453A1

公开(公告)日：2014-09-18

申请号：US14359722

申请日：2012-11-29

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Junyu Guo ,  Wilburn E. Reddick

IPC: G06T7/00 ,  G06T5/00

CPC classification number: G06T7/0012 ,  A61B5/055 ,  A61B5/7225 ,  A61B5/7271 ,  G01R33/4835 ,  G01R33/50 ,  G06T5/00 ,  G06T5/002 ,  G06T2207/10088 ,  G06T2207/20024

Abstract: Apparatus, methods, and other embodiments associated with the spectral analysis of T2 spectral data are described. One example magnetic resonance imaging (MRI) method includes accessing a data set comprising T2 spectral data associated with a magnetic resonance imaging (MRI) signal received from an object. The T2 spectral data is decomposed with multi-exponential functions to determine T2 spectra. The T2 spectral amplitude is regularized with a regularized constant. The regularized constant is sufficiently large to smooth the T2 spectra so adjacent pixels of the T2 spectral data have similar characteristics. The T2 spectral data is weighted so that the regularization is uniformly weighted for the spectral amplitudes. The T2 spectra is partitioned into intervals corresponding to myelin water fraction (MWF), tissue water fraction (TWF), Long T2 water fraction (LWF), and cerebrospinal fluid fraction (CSF). Parametric maps are generated based, at least in part, on the T2 spectral data.

Abstract translation: 描述了与T2光谱数据的光谱分析相关联的装置，方法和其它实施例。 一个例子磁共振成像（MRI）方法包括访问包括与从对象接收的磁共振成像（MRI）信号相关联的T2光谱数据的数据集。 T2光谱数据用多指数函数分解，以确定T2光谱。 T2频谱振幅用正则化常数正则化。 正则化常数足够大以平滑T2光谱，因此T2光谱数据的相邻像素具有相似的特性。 T2频谱数据被加权，使得正则化对于频谱幅度被均匀加权。 T2光谱分为对应于髓磷脂水分（MWF），组织水分（TWF），Long T2水分（LWF）和脑脊液分数（CSF）的间隔。 至少部分地基于T2光谱数据生成参数图。

公开(公告)号：US20160275680A1

公开(公告)日：2016-09-22

申请号：US15166440

申请日：2016-05-27

Applicant: St. Jude Children's Research Hospital

Inventor： Junyu Guo ,  Wilburn E. Reddick

IPC: G06T7/00 ,  A61B5/055 ,  A61B5/00 ,  G06T5/00

CPC classification number: G06T7/0012 ,  A61B5/055 ,  A61B5/7225 ,  A61B5/7271 ,  G01R33/4835 ,  G01R33/50 ,  G06T5/00 ,  G06T5/002 ,  G06T2207/10088 ,  G06T2207/20024

Abstract: Apparatus, methods, and other embodiments associated with the spectral analysis of T2 spectral data are described. One example magnetic resonance imaging (MRI) method includes accessing a data set comprising T2 spectral data associated with a magnetic resonance imaging (MRI) signal received from an object. The method also includes decomposing the T2 spectral data with multi-exponential functions to determine T2 spectra corresponding to the T2 spectral data. The T2 spectra are portioned into a plurality of intervals defined by the T2 spectral data acquired in a predetermined time period.

Abstract translation: 描述了与T2光谱数据的光谱分析相关联的装置，方法和其它实施例。 一个例子磁共振成像（MRI）方法包括访问包括与从对象接收的磁共振成像（MRI）信号相关联的T2光谱数据的数据集。 该方法还包括用多指数函数分解T2光谱数据，以确定对应于T2光谱数据的T2光谱。 T2频谱分为由在预定时间段内获取的T2频谱数据定义的多个间隔。