公开(公告)号：US20200179397A1

公开(公告)日：2020-06-11

申请号：US16707991

申请日：2019-12-09

Applicant: St. Jude Children's Research Hospital

Inventor： Jian Zuo ,  Tal Teitz ,  Jie Fang ,  Asli Goktug ,  Taosheng Chen ,  Jaeki Min ,  R. Kiplin Guy

IPC: A61K31/55 ,  A61K31/404 ,  A61K31/454 ,  A61K31/506 ,  A61K31/52 ,  A61P27/16

Abstract: In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11883491B2

公开(公告)日：2024-01-30

申请号：US16610170

申请日：2018-04-30

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Jian Zuo ,  Fei Zheng ,  Tetsuji Yamashita ,  Zoe Kellard ,  Tal Teitz ,  Jaeki Min ,  Taosheng Chen

IPC: A61K31/18 ,  A61K31/422 ,  A61K31/44 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/58 ,  A61K45/06 ,  A61K39/395 ,  A61P27/16 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/713 ,  A61K38/17

CPC classification number: A61K39/3955 ,  A61K31/18 ,  A61K31/422 ,  A61K31/44 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/58 ,  A61K31/713 ,  A61K38/1709 ,  A61K45/06 ,  A61P27/16

Abstract: Methods and compositions using an inhibitor of EGFR signaling for prevention or an inhibitor of EGFR signaling and a nucleic acid molecule encoding an atonal-associated factor for treatment of hearing loss are described.

公开(公告)号：US20230000881A1

公开(公告)日：2023-01-05

申请号：US17862656

申请日：2022-07-12

Applicant: St. Jude Children's Research Hospital

Inventor： Jian Zuo ,  Tal Teitz ,  Fang Jie ,  Goktug Asli ,  Chen Taosheng ,  Min Jaeki ,  R. Kiplin Guy

IPC: A61K31/55 ,  A61K31/404 ,  A61K31/454 ,  A61K31/506 ,  A61K31/52 ,  A61K31/519 ,  A61K31/4155 ,  A61K31/4015 ,  A61P27/16

Abstract: In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.