公开(公告)号：US11883491B2

公开(公告)日：2024-01-30

申请号：US16610170

申请日：2018-04-30

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Jian Zuo ,  Fei Zheng ,  Tetsuji Yamashita ,  Zoe Kellard ,  Tal Teitz ,  Jaeki Min ,  Taosheng Chen

IPC: A61K31/18 ,  A61K31/422 ,  A61K31/44 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/58 ,  A61K45/06 ,  A61K39/395 ,  A61P27/16 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/713 ,  A61K38/17

CPC classification number: A61K39/3955 ,  A61K31/18 ,  A61K31/422 ,  A61K31/44 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/58 ,  A61K31/713 ,  A61K38/1709 ,  A61K45/06 ,  A61P27/16

Abstract: Methods and compositions using an inhibitor of EGFR signaling for prevention or an inhibitor of EGFR signaling and a nucleic acid molecule encoding an atonal-associated factor for treatment of hearing loss are described.

公开(公告)号：US20220249604A1

公开(公告)日：2022-08-11

申请号：US17696808

申请日：2022-03-16

Applicant: St. Jude Children's Research Hospital

Inventor： Jian Zuo ,  Fei Zheng ,  Tetsuji Yamashita ,  Wanda Layman

IPC: A61K38/17 ,  A01K67/027 ,  A61K9/00 ,  A61K31/7105 ,  A61K45/06

Abstract: Methods and compositions using a nucleic acid molecule encoding an atonal-associated factor in combination with a co-transcription factor and/or inhibitor of a gene silencing complex to change the sensory perception of an animal are described.

公开(公告)号：US11331373B2

公开(公告)日：2022-05-17

申请号：US16483654

申请日：2018-01-31

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Jian Zuo ,  Fei Zheng ,  Tetsuji Yamashita ,  Wanda Layman

IPC: C12N15/11 ,  A61K38/17 ,  A01K67/027 ,  A61K9/00 ,  A61K31/7105 ,  A61K45/06

Abstract: Methods and compositions using a nucleic acid molecule encoding an atonal-associated factor in combination with a co-transcription factor and/or inhibitor of a gene silencing complex to change the sensory perception of an animal are described.