公开(公告)号：US20240287039A1

公开(公告)日：2024-08-29

申请号：US18390494

申请日：2023-12-20

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Richard E. LEE ,  Rajendra P. TANGALLAPALLY ,  Charles O. ROCK ,  Suzanne JACKOWSKI ,  Anne V. EDWARDS ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY

IPC: C07D403/04 ,  A61K31/197

CPC classification number: C07D403/04 ,  A61K31/197

Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20210061788A1

公开(公告)日：2021-03-04

申请号：US16958022

申请日：2018-12-26

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Richard E. LEE ,  Rajendra P. TANGALLAPALLY ,  Charles O. ROCK ,  Suzanne JACKOWSKI ,  Anne V. EDWARDS ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY

IPC: C07D403/04

Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20240115566A1

公开(公告)日：2024-04-11

申请号：US18257680

申请日：2021-12-16

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Suzanne JACKOWSKI ,  Charles O. ROCK ,  Matthew W. FRANK

IPC: A61K31/501 ,  A61P3/00 ,  A61P25/00 ,  G01N33/50

CPC classification number: A61K31/501 ,  A61P3/00 ,  A61P25/00 ,  G01N33/5008 ,  G01N2800/52

Abstract: The present disclosure relates to methods of identifying subjects in need of treatment for, e.g., a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. The methods may comprise assessing levels of carnitines, CoA, and/or various metabolites and biomarkers and administration of therapeutics useful in the treatment of CASTOR disorders, metabolic diseases, and/or neurological diseases. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present inventions.

公开(公告)号：US20210246113A1

公开(公告)日：2021-08-12

申请号：US17120800

申请日：2020-12-14

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Lalit Kumar SHARMA ,  Richard E. LEE ,  Charles O. ROCK ,  Suzanne JACKOWSKI ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Jiuyu LIU

IPC: C07D401/04 ,  C07D241/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D409/14 ,  C07D413/14 ,  C07D237/24 ,  C07D409/12 ,  C07D401/12 ,  C07D213/85 ,  A61P25/00 ,  A61K31/501 ,  A61P3/10

Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20250090526A1

公开(公告)日：2025-03-20

申请号：US18642382

申请日：2024-04-22

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Suzanne JACKOWSKI ,  Charles O. ROCK ,  Richard E. LEE ,  Lalit Kumar SHARMA ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Rajendra P. TANGALLAPALLY ,  Anne V. EDWARDS ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY ,  Jiuyu LIU

IPC: A61K31/501 ,  A61K31/197 ,  A61K31/205 ,  A61P3/00

Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230321092A1

公开(公告)日：2023-10-12

申请号：US18076044

申请日：2022-12-06

Applicant: St. Jude Children's Research Hospital, Inc. ,  COA Therapeutics, Inc.

Inventor： Suzanne JACKOWSKI ,  Charles O. ROCK ,  Richard E. LEE ,  Lalit Kumar SHARMA ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Rajendra P. TANGALLAPALLY ,  Anne V. EDWARDS ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY ,  Jiuyu LIU

IPC: A61K31/501 ,  A61P3/00 ,  A61K31/197 ,  A61K31/205

CPC classification number: A61K31/501 ,  A61P3/00 ,  A61K31/197 ,  A61K31/205

Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20210023081A1

公开(公告)日：2021-01-28

申请号：US16957996

申请日：2018-12-26

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Suzanne JACKOWSKI ,  Charles O. ROCK ,  Richard E. LEE ,  Lalit Kumar SHARMA ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Rajendra P. TANGALLAPALLY ,  Anne V. EDWARDS ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY ,  Jiuyu LIU

IPC: A61K31/501 ,  A61K31/205 ,  A61K31/197 ,  A61P3/00

Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.