公开(公告)号：US20240287039A1

公开(公告)日：2024-08-29

申请号：US18390494

申请日：2023-12-20

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Richard E. LEE ,  Rajendra P. TANGALLAPALLY ,  Charles O. ROCK ,  Suzanne JACKOWSKI ,  Anne V. EDWARDS ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY

IPC: C07D403/04 ,  A61K31/197

CPC classification number: C07D403/04 ,  A61K31/197

Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20210388012A1

公开(公告)日：2021-12-16

申请号：US17288493

申请日：2018-11-05

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Richard E. LEE ,  Jiuyu LIU

IPC: C07F9/6561 ,  C07D493/04 ,  A61K45/06

Abstract: In one aspect, the disclosure relates to substituted spectinomycin analogs, including substituted aminomethyl spectinomycin analogs and substituted spectinamide analogs, with increased tolerability and safety, including improved tolerability to parenteral administration. The present disclosure further pertains to methods of making disclosed compounds, pharmaceutical compositions comprising the disclosed compounds, and methods of treating microbial infections using the disclosed compounds, including methods of treating antibiotic resistant infections and tuberculosis. This abstract is intended as a scanning tool for pur-poses of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20210246113A1

公开(公告)日：2021-08-12

申请号：US17120800

申请日：2020-12-14

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Lalit Kumar SHARMA ,  Richard E. LEE ,  Charles O. ROCK ,  Suzanne JACKOWSKI ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Jiuyu LIU

IPC: C07D401/04 ,  C07D241/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D409/14 ,  C07D413/14 ,  C07D237/24 ,  C07D409/12 ,  C07D401/12 ,  C07D213/85 ,  A61P25/00 ,  A61K31/501 ,  A61P3/10

Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20210061788A1

公开(公告)日：2021-03-04

申请号：US16958022

申请日：2018-12-26

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Richard E. LEE ,  Rajendra P. TANGALLAPALLY ,  Charles O. ROCK ,  Suzanne JACKOWSKI ,  Anne V. EDWARDS ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY

IPC: C07D403/04

Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20250090526A1

公开(公告)日：2025-03-20

申请号：US18642382

申请日：2024-04-22

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Suzanne JACKOWSKI ,  Charles O. ROCK ,  Richard E. LEE ,  Lalit Kumar SHARMA ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Rajendra P. TANGALLAPALLY ,  Anne V. EDWARDS ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY ,  Jiuyu LIU

IPC: A61K31/501 ,  A61K31/197 ,  A61K31/205 ,  A61P3/00

Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230321092A1

公开(公告)日：2023-10-12

申请号：US18076044

申请日：2022-12-06

Applicant: St. Jude Children's Research Hospital, Inc. ,  COA Therapeutics, Inc.

Inventor： Suzanne JACKOWSKI ,  Charles O. ROCK ,  Richard E. LEE ,  Lalit Kumar SHARMA ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Rajendra P. TANGALLAPALLY ,  Anne V. EDWARDS ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY ,  Jiuyu LIU

IPC: A61K31/501 ,  A61P3/00 ,  A61K31/197 ,  A61K31/205

CPC classification number: A61K31/501 ,  A61P3/00 ,  A61K31/197 ,  A61K31/205

Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20210023081A1

公开(公告)日：2021-01-28

申请号：US16957996

申请日：2018-12-26

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Suzanne JACKOWSKI ,  Charles O. ROCK ,  Richard E. LEE ,  Lalit Kumar SHARMA ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Rajendra P. TANGALLAPALLY ,  Anne V. EDWARDS ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY ,  Jiuyu LIU

IPC: A61K31/501 ,  A61K31/205 ,  A61K31/197 ,  A61P3/00

Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.