公开(公告)号：US20130178536A1

公开(公告)日：2013-07-11

申请号：US13744719

申请日：2013-01-18

Applicant: STC. UNM

Inventor： David L. Vander Jagt ,  Lorraine M. Deck ,  Robert E. Royer ,  John E. Heidrich ,  Laurel O. Sillerud

IPC: A61K31/136 ,  A61K31/05 ,  A61K31/085

CPC classification number: A61K31/136 ,  A61K31/05 ,  A61K31/085 ,  A61K31/381 ,  A61K31/44 ,  A61K31/525 ,  A61K31/66 ,  C07D213/30 ,  C07D333/16

Abstract: The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and/or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene. A method of treating or reducing the likelihood of Alzheimer's disease in a patient is an additional embodiment of the present invention.

Abstract translation: 本发明涉及治疗患有癌症或癌前病症，炎性疾病或病症，和/或中风或其他缺血性疾病或病症的受试者的方法，所述方法包括对需要的受试者或患者施用 组合物，其包含治疗有效量的取代的顺式或反式二苯乙烯。 治疗或降低患者中阿尔茨海默氏病的可能性的方法是本发明的另外的实施方案。

公开(公告)号：US20160287531A1

公开(公告)日：2016-10-06

申请号：US15036968

申请日：2014-12-05

Applicant: STC. UNM

Inventor： David L VANDER JAGT ,  Lorraine M. Deck ,  Robert E Royer ,  John E Heidrich

IPC: A61K31/12 ,  A61K31/444 ,  A61K9/00 ,  A61K31/05 ,  A61K31/136 ,  A61K45/06 ,  A61K31/222 ,  A61K31/085

CPC classification number: A61K31/12 ,  A61K9/0014 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/121 ,  A61K31/136 ,  A61K31/137 ,  A61K31/222 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/444 ,  A61K45/06

Abstract: The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.

Abstract translation: 本发明涉及治疗患有皮肤疾病或病症的受试者的方法，所述方法包括向需要的受试者或患者施用包含治疗有效量的经取代的顺式或反式二苯乙烯或二苯乙烯的组合物 混合 治疗或减少患者皮肤疾病或病症的可能性的方法是本发明的另外的实施方案。 本发明优选的药物组合物包括含有治疗有效量的取代的顺式或反式二苯乙烯或芪混合物和至少一种抗生素的纳米乳剂。