公开(公告)号：US20170165375A1

公开(公告)日：2017-06-15

申请号：US14781817

申请日：2014-04-02

Applicant: STC. UNM ,  SANDIA CORPORATION

Inventor： Carlee Erin Ashley ,  Eric C. Carnes ,  Terry Wu ,  Linda A. Felton ,  Darryl Y. Sasaki

IPC: A61K9/51 ,  A61K9/50 ,  A61K31/5383 ,  A61K31/65 ,  A61K31/546 ,  A61K31/635 ,  A61K31/505 ,  A61K9/00 ,  A61K9/127 ,  A61K31/7036

CPC classification number: A61K31/7036 ,  A61K9/0053 ,  A61K9/1271 ,  A61K9/1274 ,  A61K9/5021 ,  A61K9/5123 ,  A61K31/505 ,  A61K31/5383 ,  A61K31/546 ,  A61K31/635 ,  A61K31/65 ,  A61K47/52 ,  A61K47/60 ,  A61K47/62 ,  A61K47/68 ,  A61K47/6913 ,  A61K47/6917 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00 ,  Y02A50/404 ,  Y02A50/406 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

Abstract: The invention provides novel antibiotic protocells comprising mesoporous nanoparticles encapsulated within a lipid bi- or multilayer. The nanoparticles have pore sizes and surface chemistries that enable facile adsorption and intracellular presentation of antibiotics which are effective in the treatment of a wide variety of bacterial infections, including F. tularensis, B. pseudomallei and P. aeruginosa-related infections. Related pharmaceutical compositions and methods of treatment are also provided.