公开(公告)号：US20160338954A1

公开(公告)日：2016-11-24

申请号：US15023110

申请日：2014-09-18

Applicant: STC. UNM ,  SANDIA CORPORATION

Inventor： C. Jeffrey Brinker ,  Yu-Shen Lin

IPC: A61K9/127 ,  A61K38/16 ,  C12N15/88 ,  A61K39/395 ,  A61K9/51 ,  A61K31/7088 ,  A61K38/43

CPC classification number: A61K9/1271 ,  A61K9/14 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  B82Y5/00 ,  B82Y15/00 ,  C12N15/88

Abstract: In one aspect, the invention provides novel monodisperse, colloidally-stable, torroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia base-catalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

Abstract translation: 一方面，本发明提供了由在低表面活性剂条件下使用氨碱催化法制备的椭圆形介孔二氧化硅纳米粒子（MSNP）合成的新型单分散，胶体稳定的环形介孔二氧化硅纳米粒子（TMSNP）。 值得注意的是，TMSNPs可以与小分子活性剂，siRNA，mRNA，质粒和其他货物同时加载，并且可以用于诊断和/或治疗各种疾病，包括癌症，细菌感染 和/或病毒感染等。 还提供了相关的原细胞，药物组合物和治疗和诊断方法。