公开(公告)号：US11608322B2

公开(公告)日：2023-03-21

申请号：US17291113

申请日：2019-11-05

Applicant: STUDIENGESELLSCHAFT KOHLE MBH

Inventor： Tobias Ritter ,  Florian Berger

IPC: C07D339/08

Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.

公开(公告)号：US12065422B2

公开(公告)日：2024-08-20

申请号：US18099060

申请日：2023-01-19

Applicant: STUDIENGESELLSCHAFT KOHLE MBH

Inventor： Tobias Ritter ,  Florian Berger

IPC: C07D309/08 ,  C07D339/08

CPC classification number: C07D339/08

Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.

公开(公告)号：US11179710B2

公开(公告)日：2021-11-23

申请号：US16083160

申请日：2017-03-09

Applicant: President and Fellows of Harvard College ,  Studiengesellschaft Kohle mbH

Inventor： Tobias Ritter ,  Jeffrey Garber ,  Kumiko Yamamoto

IPC: C07D471/04 ,  B01J23/44 ,  B01J31/30 ,  B01J31/18 ,  C07C17/12 ,  C07C23/10

Abstract: Provided herein are palladium complexes comprising a ligand of Formula (A′) and a ligand of Formula (B), wherein R1-R18 are as defined herein. The palladium complexes are useful in methods of fluorinating aryl and heteroaryl substrates. Further provided are compositions and kits comprising the palladium complexes.

公开(公告)号：US11046628B2

公开(公告)日：2021-06-29

申请号：US16635266

申请日：2018-07-10

Applicant: STUDIENGESELLSCHAFT KOHLE MBH ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Tobias Ritter ,  Constanze Neumann ,  Mohammad Hassan Beyzavi ,  Martin Georg Strebl-Bantillo ,  Debashis Mandal

IPC: C07C17/16 ,  C07B59/00 ,  C07C231/12 ,  C07D451/02 ,  C07C233/12 ,  C07F15/00

Abstract: The present invention refers to a process for transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for positron emission tomography (PET) imaging.

公开(公告)号：US10947186B2

公开(公告)日：2021-03-16

申请号：US16613822

申请日：2018-05-08

Applicant: STUDIENGESELLSCHAFT KOHLE MBH

Inventor： Tobias Ritter ,  Fei Ye

IPC: C07C253/12 ,  B01J31/24 ,  C07C255/31 ,  C07C255/34 ,  C07D213/64 ,  C07D333/24

Abstract: The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles and the catalyst used in the present process.

公开(公告)号：US20190099748A1

公开(公告)日：2019-04-04

申请号：US16083160

申请日：2017-03-09

Applicant: President and Fellows of Harvard College ,  Studiengesellschaft Kohle mbH

Inventor： Tobias Ritter ,  Jeffrey Garber ,  Kumiko Yamamoto

IPC: B01J31/30 ,  B01J31/18 ,  C07C23/10 ,  C07C17/12

Abstract: Provided herein are palladium complexes comprising a ligand of Formula (A′) and a ligand of Formula (B), wherein R1-R18 are as defined herein. The palladium complexes are useful in methods of fluorinating aryl and heteroaryl substrates. Further provided are compositions and kits comprising the palladium complexes.