公开(公告)号：US20230312859A1

公开(公告)日：2023-10-05

申请号：US18043786

申请日：2021-02-24

申请人： SUNRESIN NEW MATERIALS CO. LTD.

发明人： Chaoyang WANG ,  Cheng ZHANG ,  Dan WU ,  Weijie ZHAO ,  Yanjun LI ,  Qiong LIU ,  Xiaokang KOU

IPC分类号： C08J9/28 ,  C08F222/34 ,  C08F2/18

CPC分类号： C08J9/28 ,  C08F222/34 ,  C08F2/18 ,  C08J2201/026 ,  C08J2205/042 ,  C08J2325/12

摘要： A porous resin used to solid phase synthesis and a preparation method therefor, specifically being a porous resin having functional groups being an amino group or a hydroxyl group and a preparation method therefor. Using an olefin compound containing two cyano groups as a modified monomer, using a high internal phase emulsion as a pore-foaming agent, and performing suspension polymerization to prepare the porous resin. And then functionalizing the porous resin to obtain the porous resin having functional groups being an amino group or a hydroxyl group. Different from the existing preparation method, the modified monomer can make the distribution of the functional groups more uniform, and make the swelling degrees of the porous resin in different solvents close. The high internal phase emulsion pore-foaming agent can make the pore size distribution of the carrier narrower. The porous resin can be used as a solid phase synthesis carrier to prepare an oligonucleotide, and the use of the carrier is beneficial for improving the yield and purity of the oligonucleotide.

公开(公告)号：US20240010774A1

公开(公告)日：2024-01-11

申请号：US18043940

申请日：2021-02-02

申请人： SUNRESIN NEW MATERIALS CO. LTD.

发明人： Chaoyang WANG ,  Cheng ZHANG ,  Dan WU ,  Weijie ZHAO ,  Yanjun LI ,  Qiong LIU ,  Xiaokang KOU

IPC分类号： C08F212/12 ,  C08F212/08 ,  C08F212/14 ,  C08F220/44 ,  C08F220/56 ,  C08J9/28 ,  C08J9/36

CPC分类号： C08F212/12 ,  C08F212/08 ,  C08F212/18 ,  C08F220/44 ,  C08F220/56 ,  C08J9/286 ,  C08J9/36 ,  C08J2201/05 ,  C08J2325/12 ,  C08J2205/042

摘要： A solid-phase synthesis carrier, a preparation method therefor and the use thereof, wherein a diene cross-linking agent with a similar reactivity ratio to styrene and two vinyl groups thereof not on the same benzene ring is selected as a cross-linking monomer, and is subjected to suspension polymerization to obtain a porous resin. The porous resin is then functionalized to obtain a porous resin with an amino or hydroxyl functional group. Compared with existing preparation methods, the reactivity ratio of the cross-linking agent and styrene is similar, which is beneficial to improving the uniformity of the chemical structure in the resin, forming uniformly distributed active sites and channels, and is beneficial to improving the reaction efficiency and reducing the mass transfer resistance. The preparation of oligonucleotides by using such a carrier as a solid-phase synthesis carrier can improve the yield and purity of the oligonucleotides.