公开(公告)号：US20180230138A1

公开(公告)日：2018-08-16

申请号：US15751163

申请日：2016-08-26

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Xiaojun WANG ,  Pingjian ZHOU ,  Chuanwen YANG ,  Changwei HUANG ,  Shaohui XIONG ,  Yingjun ZHANG ,  Jiancun ZHANG

IPC: C07D407/10 ,  C07D307/85 ,  C07D413/14 ,  C07D409/10 ,  C07D413/10 ,  C07D405/10 ,  C07D407/12 ,  C07D471/04 ,  C07D417/10 ,  C07D411/10 ,  C07D417/14 ,  C07D407/14 ,  A61K45/06 ,  A61K31/343 ,  A61K31/4245 ,  A61K31/38 ,  A61K31/422 ,  A61K31/4196 ,  A61K31/4192 ,  A61K31/5377 ,  A61K31/351 ,  A61K31/41 ,  A61K31/382 ,  A61K31/397 ,  A61K31/4178 ,  A61K31/423 ,  A61K31/36 ,  A61K31/437 ,  A61K31/381 ,  A61K31/357 ,  A61K31/427 ,  A61K31/39 ,  A61K31/541 ,  A61K31/443 ,  A61K31/4355 ,  C07D493/04

CPC classification number: C07D407/10 ,  A61K31/275 ,  A61K31/343 ,  A61K31/351 ,  A61K31/357 ,  A61K31/36 ,  A61K31/38 ,  A61K31/381 ,  A61K31/382 ,  A61K31/39 ,  A61K31/397 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/443 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C209/42 ,  C07C215/48 ,  C07C233/54 ,  C07C255/29 ,  C07C255/46 ,  C07C277/02 ,  C07D307/85 ,  C07D405/10 ,  C07D407/12 ,  C07D407/14 ,  C07D409/10 ,  C07D411/10 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D493/04

Abstract: The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases.

公开(公告)号：US20210101882A1

公开(公告)日：2021-04-08

申请号：US16500266

申请日：2018-04-10

Applicant: SUNSHINE LAKE PHARMA CO., LTD. ,  NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

Inventor： Yinglin ZUO ,  Xiaojun WANG ,  Chuanwen YANG ,  Jiancheng WANG ,  Shengtian CAO ,  Fangyuan WU ,  Yingjun ZHANG ,  Siegfried GOLDMANN

IPC: C07D403/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14

Abstract: A class of fluorine-substituted indazole compounds and uses thereof, further to pharmaceutical compositions containing these compounds. The compounds and pharmaceutical compositions of the invention can be used as soluble guanylate cyclase simulators.

公开(公告)号：US20240239746A1

公开(公告)日：2024-07-18

申请号：US18288309

申请日：2022-04-19

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Jiancheng WANG ,  Yingxun ZHANG ,  Chuanwen YANG ,  Qiao ZONG ,  Facheng MA ,  Xiaohong DING ,  Xiaojun WANG

IPC: C07D207/34 ,  C07D403/06 ,  C12N9/18 ,  C12P13/02

CPC classification number: C07D207/34 ,  C07D403/06 ,  C12N9/18 ,  C12P13/02 ,  C12Y301/01

Abstract: A preparation method for a pyrrole amide compound, as shown in formula (II). The preparation method includes: reacting a compound of formula (III) with a compound of formula (IV) in the presence of a palladium catalyst and a ligand, wherein X is Br or I; R is H, D, F, Cl, Br, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl or C1-4 haloalkoxy; and PG1 is benzyl or substituted benzyl.

公开(公告)号：US20210206760A1

公开(公告)日：2021-07-08

申请号：US17056466

申请日：2019-05-20

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Chuanwen YANG ,  Xiaojun WANG ,  Yinglin ZUO ,  Yingjun ZHANG ,  Jiancheng WANG ,  Hui WANG ,  Bo CHI

IPC: C07D471/04 ,  A61K45/06 ,  A61K31/4375 ,  A61K31/616

Abstract: A phenyl-substituted dihydronaphthyridine compound and use thereof, and further relates to a pharmaceutical composition including the compound. According to the present invention, the compound or the pharmaceutical composition can be used as a mineralocorticoid receptor antagonist.