公开(公告)号：US10555930B2

公开(公告)日：2020-02-11

申请号：US15778220

申请日：2016-11-28

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Pengcho Tang ,  Zheng Gu ,  Wuyong Wu ,  Zongyuan Zhang ,  Panpan Kang ,  Tong Qu

IPC: A61K31/357 ,  A61K45/06 ,  A61K31/401 ,  A61K31/7048 ,  C07D493/08 ,  C07D207/28 ,  C07H7/04 ,  A61P5/48 ,  A61P9/10 ,  A61P13/12 ,  C07H1/00

Abstract: This present invention relates to a complex of a glucopyranosyl derivative and L-pyroglutamic acid as a sodium dependent glucose cotransporter (SGLT) inhibitor, and preparation processes thereof, and a pharmaceutical composition containing the complex, and their uses in the manufacture of a medicament for treating diabetes and/or diabetes-related diseases.

公开(公告)号：US09394329B2

公开(公告)日：2016-07-19

申请号：US14435730

申请日：2014-09-26

Applicant: Sunshine Lake Pharma Co., Ltd.

Inventor： Yonggang Wei ,  Jiaping Wen ,  Guozhi Zhu ,  Yonghua Lu ,  Heran Wang ,  Yincai Wang ,  Mingyun Yuan ,  Zheng Gu ,  Wuyong Wu ,  Panpan Kang ,  Zongyuan Zhang ,  Gang Chen ,  Pengcho Tang

IPC: C07H15/00 ,  C07H15/04 ,  C07H9/04 ,  C07H7/04 ,  A61K45/06 ,  A61K31/7034 ,  A61K31/7048

CPC classification number: C07H15/00 ,  A61K31/7034 ,  A61K31/7048 ,  A61K45/06 ,  C07H7/04 ,  C07H9/04 ,  C07H15/04 ,  A61K2300/00

Abstract: Disclosed are glucopyranosyl derivatives used as sodium dependent glucose cotransporters (SGLTs) inhibitors, intermediates or preparation processes thereof, and pharmaceutical uses thereof, especially glucopyranosyl derivatives represented by Formula (I), or pharmaceutically acceptable salts or all stereoisomers thereof, pharmaceutical compositions containing these derivatives and their uses for treatment of diabetes and diabetes-related diseases.

Abstract translation: 公开了用作钠依赖性葡萄糖共转运剂（SGLTs）抑制剂，其中间体或其制备方法及其药学用途，特别是由式（I）表示的吡喃葡萄糖基衍生物或其药学上可接受的盐或全部立体异构体的吡喃葡萄糖苷衍生物，含有这些衍生物的药物组合物 及其用于治疗糖尿病和糖尿病相关疾病的用途。

公开(公告)号：US20150266916A1

公开(公告)日：2015-09-24

申请号：US14435730

申请日：2014-09-26

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Yonggang Wei ,  Jiaping Wen ,  Guozhi Zhu ,  Yonghua Lu ,  Heran Wang ,  Yincai Wang ,  Mingyun Yuan ,  Zheng Gu ,  Wuyong Wu ,  Panpan Kang ,  Zongyuan Zhang ,  Gang Chen ,  Pengcho Tang

IPC: C07H15/00 ,  A61K31/7048

CPC classification number: C07H15/00 ,  A61K31/7034 ,  A61K31/7048 ,  A61K45/06 ,  C07H7/04 ,  C07H9/04 ,  C07H15/04 ,  A61K2300/00

Abstract: Disclosed are glucopyranosyl derivatives used as sodium dependent glucose cotransporters (SGLTs) inhibitors, intermediates or preparation processes thereof, and pharmaceutical uses thereof, especially glucopyranosyl derivatives represented by Formula (I), or pharmaceutically acceptable salts or all stereoisomers thereof, pharmaceutical compositions containing these derivatives and their uses for treatment of diabetes and diabetes-related diseases.

Abstract translation: 公开了用作钠依赖性葡萄糖共转运剂（SGLTs）抑制剂，其中间体或其制备方法及其药学用途，特别是由式（I）表示的吡喃葡萄糖基衍生物或其药学上可接受的盐或全部立体异构体的吡喃葡萄糖苷衍生物，含有这些衍生物的药物组合物 及其用于治疗糖尿病和糖尿病相关疾病的用途。