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公开(公告)号：US10555930B2
公开(公告)日：2020-02-11
申请号：US15778220
申请日：2016-11-28
发明人： Pengcho Tang , Zheng Gu , Wuyong Wu , Zongyuan Zhang , Panpan Kang , Tong Qu
IPC分类号： A61K31/357 , A61K45/06 , A61K31/401 , A61K31/7048 , C07D493/08 , C07D207/28 , C07H7/04 , A61P5/48 , A61P9/10 , A61P13/12 , C07H1/00
摘要： This present invention relates to a complex of a glucopyranosyl derivative and L-pyroglutamic acid as a sodium dependent glucose cotransporter (SGLT) inhibitor, and preparation processes thereof, and a pharmaceutical composition containing the complex, and their uses in the manufacture of a medicament for treating diabetes and/or diabetes-related diseases.
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2.发明授权公开(公告)号：US09567300B2
公开(公告)日：2017-02-14
申请号：US14378975
申请日：2013-06-25
发明人： Zheng Gu , Guanpeng Qiu , Wuyong Wu , Panpan Kang , Zongyuan Zhang , Gang Chen , Chengsheng Lan , Yonggang Wei , Jiaping Wen , Guozhi Zhu , Yonghua Lu , Heran Wang , Yincai Wang , Mingyun Yuan , Kangzhi Ye , Guizhuan Su , PengCho Tang
IPC分类号： C07D207/16 , A61K31/40 , C07D405/12 , C07D209/52 , A61K31/403 , C07C217/52 , A61K45/06 , C07C255/47 , C07C213/02 , C07C253/30 , C07C249/08 , A61K31/4025
CPC分类号： C07D207/16 , A61K31/40 , A61K31/4025 , A61K31/403 , A61K45/06 , C07C213/02 , C07C217/52 , C07C249/08 , C07C253/30 , C07C255/47 , C07C2601/02 , C07C2602/22 , C07C2603/94 , C07D209/52 , C07D405/12 , C07C251/34 , A61K2300/00
摘要： The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in general formula (I), and to the preparation method therefor and pharmaceutical compositions comprising the derivatives, and to the use thereof as a therapeutical agent, especially as a DPP-IV inhibitor. The definition of each substituent in formula (I) is the same as the definition in the description.
摘要翻译： 本发明涉及六氢蛇嘌呤衍生物，其制备方法及其药物用途，特别是通式（I）所示的六氢蛇嘌呤衍生物或立体异构体或其药学上可接受的盐及其制备方法和药物组合物，其包含 衍生物和其作为治疗剂的用途，特别是作为DPP-IV抑制剂。 式（I）中每个取代基的定义与描述中的定义相同。
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公开(公告)号：US11186602B2
公开(公告)日：2021-11-30
申请号：US16965438
申请日：2019-01-29
发明人： Zheng Gu , Wuyong Wu , Panpan Kang , Tong Qu , Zongyuan Zhang , Weiming Huang , Tianyun Wu , Yingjun Zhang
IPC分类号： C07H9/04 , A61P3/10 , A61K31/7048 , A61K45/06
摘要： A glucopyranosyl derivative is used as an inhibitor of sodium-dependent glucose transporters (SGLTs), particularly being used as an inhibitor of sodium-dependent glucose transporter-1 (SGLT1), and a pharmaceutically acceptable salt or stereoisomer thereof, further relating to a pharmaceutical composition containing the derivative. The compound and a pharmaceutical composition is used thereof in the preparation of a drug for treating diabetes and diabetes-related diseases.
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4.发明申请公开(公告)号：US20150299118A1
公开(公告)日：2015-10-22
申请号：US14378975
申请日：2013-06-25
发明人： Zheng Gu , Guanpeng Qiu , Wuyong Wu , Panpan Kang , Zongyuan Zhang , Gang Chen , Chengsheng Lan , Yonggang Wei , Jiaping Wen , Guozhi Zhu , Yonghua Lu , Heran Wang , Yincai Wang , Mingyun Yuan , Kangzhi Ye , Guizhuan Su , PengCho Tang
IPC分类号： C07D207/16 , A61K31/40 , C07D405/12 , C07D209/52 , A61K31/403 , C07C217/52 , A61K45/06
CPC分类号： C07D207/16 , A61K31/40 , A61K31/4025 , A61K31/403 , A61K45/06 , C07C213/02 , C07C217/52 , C07C249/08 , C07C253/30 , C07C255/47 , C07C2601/02 , C07C2602/22 , C07C2603/94 , C07D209/52 , C07D405/12 , C07C251/34 , A61K2300/00
摘要： The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in general formula (I), and to the preparation method therefor and pharmaceutical compositions comprising the derivatives, and to the use thereof as a therapeutical agent, especially as a DPP-IV inhibitor. The definition of each substituent in formula (I) is the same as the definition in the description.
摘要翻译： 本发明涉及六氢蛇嘌呤衍生物，其制备方法及其药物用途，特别是通式（I）所示的六氢蛇嘌呤衍生物或立体异构体或其药学上可接受的盐及其制备方法和药物组合物，其包含 衍生物和其作为治疗剂的用途，特别是作为DPP-IV抑制剂。 式（I）中每个取代基的定义与描述中的定义相同。
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公开(公告)号：US11084842B2
公开(公告)日：2021-08-10
申请号：US16960488
申请日：2019-01-22
发明人： Zheng Gu , Wuyong Wu , Tong Qu , Panpan Kang , Zongyuan Zhang , Weiming Huang , Jianyu Liu , Yingjun Zhang
IPC分类号： C07H7/04 , C07H15/207
摘要： A glucopyranosyl derivative as a sodium-dependent glucose transporters inhibitor, especially as a SGLT1 inhibitor, a pharmaceutically acceptable salt or a stereoisomer thereof, a pharmaceutical composition thereof, and the uses of the compound and pharmaceutical composition thereof in the preparation of drugs for the treatment of diabetes and diabetes-related diseases.
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公开(公告)号：US09394329B2
公开(公告)日：2016-07-19
申请号：US14435730
申请日：2014-09-26
发明人： Yonggang Wei , Jiaping Wen , Guozhi Zhu , Yonghua Lu , Heran Wang , Yincai Wang , Mingyun Yuan , Zheng Gu , Wuyong Wu , Panpan Kang , Zongyuan Zhang , Gang Chen , Pengcho Tang
IPC分类号： C07H15/00 , C07H15/04 , C07H9/04 , C07H7/04 , A61K45/06 , A61K31/7034 , A61K31/7048
CPC分类号： C07H15/00 , A61K31/7034 , A61K31/7048 , A61K45/06 , C07H7/04 , C07H9/04 , C07H15/04 , A61K2300/00
摘要： Disclosed are glucopyranosyl derivatives used as sodium dependent glucose cotransporters (SGLTs) inhibitors, intermediates or preparation processes thereof, and pharmaceutical uses thereof, especially glucopyranosyl derivatives represented by Formula (I), or pharmaceutically acceptable salts or all stereoisomers thereof, pharmaceutical compositions containing these derivatives and their uses for treatment of diabetes and diabetes-related diseases.
摘要翻译： 公开了用作钠依赖性葡萄糖共转运剂（SGLTs）抑制剂，其中间体或其制备方法及其药学用途，特别是由式（I）表示的吡喃葡萄糖基衍生物或其药学上可接受的盐或全部立体异构体的吡喃葡萄糖苷衍生物，含有这些衍生物的药物组合物 及其用于治疗糖尿病和糖尿病相关疾病的用途。
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公开(公告)号：US20150266916A1
公开(公告)日：2015-09-24
申请号：US14435730
申请日：2014-09-26
发明人： Yonggang Wei , Jiaping Wen , Guozhi Zhu , Yonghua Lu , Heran Wang , Yincai Wang , Mingyun Yuan , Zheng Gu , Wuyong Wu , Panpan Kang , Zongyuan Zhang , Gang Chen , Pengcho Tang
IPC分类号： C07H15/00 , A61K31/7048
CPC分类号： C07H15/00 , A61K31/7034 , A61K31/7048 , A61K45/06 , C07H7/04 , C07H9/04 , C07H15/04 , A61K2300/00
摘要： Disclosed are glucopyranosyl derivatives used as sodium dependent glucose cotransporters (SGLTs) inhibitors, intermediates or preparation processes thereof, and pharmaceutical uses thereof, especially glucopyranosyl derivatives represented by Formula (I), or pharmaceutically acceptable salts or all stereoisomers thereof, pharmaceutical compositions containing these derivatives and their uses for treatment of diabetes and diabetes-related diseases.
摘要翻译： 公开了用作钠依赖性葡萄糖共转运剂（SGLTs）抑制剂，其中间体或其制备方法及其药学用途，特别是由式（I）表示的吡喃葡萄糖基衍生物或其药学上可接受的盐或全部立体异构体的吡喃葡萄糖苷衍生物，含有这些衍生物的药物组合物 及其用于治疗糖尿病和糖尿病相关疾病的用途。
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