公开(公告)号：US20230044304A1

公开(公告)日：2023-02-09

申请号：US17727651

申请日：2022-04-22

Applicant: SYK Technologies LLC

Inventor： J.W. Randolph Miller ,  Ross M. Wille ,  John J. Miller ,  Stephen H. Fairbanks

IPC: A61M16/14 ,  A61K47/02 ,  A61M16/00 ,  A61M16/20 ,  A61K33/00

Abstract: Topical applications that provide a nitric oxide therapy to a surface are provided. Systems for providing a topical nitric oxide therapy can comprise a nitrite medium in a first container, the nitrite medium comprising about 3% of a nitrite component by weight. The system comprises an acidic medium in a second container, the acidic medium comprising about 9% by weight of one or more acidic reactants. The nitrite medium and the acidic medium are configured to be combined to form a nitric oxide topical medium producing nitric oxide suitable for topical application and suitable for administering nitric oxide therapy wherein a therapeutically effective amount of the nitric oxide topical medium is applied to a treatment surface suitable for receiving nitric oxide therapy, whereby the application of the therapeutically effective amount is adapted to deliver a dose of nitric oxide at the treatment surface of a patient.

公开(公告)号：US20230001125A1

公开(公告)日：2023-01-05

申请号：US17727630

申请日：2022-04-22

Applicant: SYK Technologies LLC

Inventor： J.W. Randolph Miller ,  John J. Miller ,  Stephen H. Fairbanks

IPC: A61M16/14 ,  A61K47/02 ,  A61M16/00 ,  A61M16/20 ,  A61K33/00

Abstract: An apparatus for controlled delivery of nitric oxide. A pump draws air through an activated carbon filter and into a reaction chamber. The generation of nitric oxide occurs in the reaction chamber. A second pump draws the gas in the reaction chamber through a calcium hydroxide filter and delivers the nitric oxide through an orifice, or aperture, that controls the flow of nitric oxide delivered. The nitric oxide is filtered through a calcium hydroxide filter just prior to being made available for various nitric oxide therapies. Topical applications that provide a nitric oxide therapy to a surface are also provided.

公开(公告)号：US20160256841A1

公开(公告)日：2016-09-08

申请号：US15066173

申请日：2016-03-10

Applicant: SYK TECHNOLOGIES, LLC

Inventor： J.W. Randolph Miller ,  John J. Miller ,  Stephen H. Fairbanks

IPC: B01J7/00 ,  A61L2/20 ,  A61L2/00 ,  A61K33/00 ,  A61K9/00 ,  C01B21/24 ,  A61L2/26

CPC classification number: B01J7/00 ,  A61K9/0014 ,  A61K33/00 ,  A61L2/0005 ,  A61L2/20 ,  A61L2/26 ,  C01B21/24

Abstract: An apparatus for controlled delivery of nitric oxide. A pump draws air through an activated carbon filter and into a reaction chamber. The generation of nitric oxide occurs in the reaction chamber. A second pump draws the gas in the reaction chamber through a calcium hydroxide filter and delivers the nitric oxide through an orifice, or aperture, that controls the flow of nitric oxide delivered. The nitric oxide is filtered through a calcium hydroxide filter just prior to being made available for various nitric oxide therapies. Topical applications that provide a nitric oxide therapy to a surface are also provided.

Abstract translation: 用于一氧化氮控制递送的装置。 泵将空气通过活性炭过滤器吸入反应室。 在反应室中产生一氧化氮。 第二个泵通过氢氧化钙过滤器将反应室中的气体吸入，并将一氧化氮通过一个控制一氧化氮输送流量的孔或孔。 在一氧化氮过滤器刚好被用于各种一氧化氮治疗之前，一氧化氮被过滤。 还提供了向表面提供一氧化氮治疗的局部应用。