公开(公告)号：US10647691B2

公开(公告)日：2020-05-12

申请号：US16300205

申请日：2016-05-13

Applicant: SYMRISE AG

Inventor： Harry Erfurt ,  Maria Weber ,  Hans-Jürgen Niemeyer ,  Marcus Rudolf Götz ,  Matthias Winkler

IPC: C07D311/80 ,  B01D15/18 ,  C07C37/00 ,  C07C67/02 ,  C07C67/343

Abstract: The present invention relates to methods for purifying one or two cannabinoid compounds using simulated moving bed chromatography, wherein the cannabinoid compound(s) is/are obtained in the extract and/or the raffinate with the total amount of isomeric impurities being below detection level. In particular, the present invention relates to methods for the purification of cannabidiol, trans-(−)-delta-9-tetrahydrocannabinol, cannabidivarin, trans-(−)-delta-9-tetrahydrocannabivarin and cannabigerol which have been obtained by enantiopure synthesis.

公开(公告)号：US09078872B2

公开(公告)日：2015-07-14

申请号：US14248883

申请日：2014-04-09

Applicant: Symrise AG

Inventor： Harry Erfurt ,  René Schuld ,  Melanie Stürtz ,  Christian Wintermeyer ,  Hans-Jürgen Niemeyer

IPC: A61K31/353 ,  A61K31/192 ,  A61K8/36 ,  A61K8/49 ,  A23L3/3517 ,  A23L3/3508 ,  A23L1/30 ,  A61Q19/00 ,  A61K31/352

CPC classification number: A61K31/353 ,  A23L3/3508 ,  A23L3/3517 ,  A23L33/105 ,  A61K8/36 ,  A61K8/498 ,  A61K31/192 ,  A61K31/352 ,  A61K36/736 ,  A61K2800/522 ,  A61Q17/04 ,  A61Q19/00 ,  A61K2300/00

Abstract: Suggested is an antioxidant composition, comprising (a) caffeic acid, (b) sinapinic acid and, optionally, (c) polyphenols, with the proviso that components (a) and (b) are present in a weight ratio of about 85:15 to about 98:2.

Abstract translation: 建议一种抗氧化剂组合物，其包含（a）咖啡酸，（b）芥子酸和任选的（c）多酚，条件是组分（a）和（b）以约85:15的重量比存在 至约98：2。

公开(公告)号：US20140309294A1

公开(公告)日：2014-10-16

申请号：US14248883

申请日：2014-04-09

Applicant: Symrise AG

Inventor： Harry Erfurt ,  René Schuld ,  Melanie Stürtz ,  Christian Wintermeyer ,  Hans-Jürgen Niemeyer

IPC: A61K31/353 ,  A61K8/36 ,  A23L3/3517 ,  A61Q19/00 ,  A23L1/30 ,  A23L3/3508 ,  A61K31/192 ,  A61K8/49

CPC classification number: A61K31/353 ,  A23L3/3508 ,  A23L3/3517 ,  A23L33/105 ,  A61K8/36 ,  A61K8/498 ,  A61K31/192 ,  A61K31/352 ,  A61K36/736 ,  A61K2800/522 ,  A61Q17/04 ,  A61Q19/00 ,  A61K2300/00

Abstract: Suggested is an antioxidant composition, comprising (a) caffeic acid, (b) sinapinic acid and, optionally, (c) polyphenols, with the proviso that components (a) and (b) are present in a weight ratio of about 85:15 to about 98:2.

Abstract translation: 建议一种抗氧化剂组合物，其包含（a）咖啡酸，（b）芥子酸和任选的（c）多酚，条件是组分（a）和（b）以约85:15的重量比存在 至约98：2。