公开(公告)号：US10647691B2

公开(公告)日：2020-05-12

申请号：US16300205

申请日：2016-05-13

Applicant: SYMRISE AG

Inventor： Harry Erfurt ,  Maria Weber ,  Hans-Jürgen Niemeyer ,  Marcus Rudolf Götz ,  Matthias Winkler

IPC: C07D311/80 ,  B01D15/18 ,  C07C37/00 ,  C07C67/02 ,  C07C67/343

Abstract: The present invention relates to methods for purifying one or two cannabinoid compounds using simulated moving bed chromatography, wherein the cannabinoid compound(s) is/are obtained in the extract and/or the raffinate with the total amount of isomeric impurities being below detection level. In particular, the present invention relates to methods for the purification of cannabidiol, trans-(−)-delta-9-tetrahydrocannabinol, cannabidivarin, trans-(−)-delta-9-tetrahydrocannabivarin and cannabigerol which have been obtained by enantiopure synthesis.

公开(公告)号：US11485700B2

公开(公告)日：2022-11-01

申请号：US17255590

申请日：2018-06-28

Applicant: SYMRISE AG

Inventor： Bernd Fiebich ,  Matthias Winkler ,  Marcus Rudolf Götz ,  Oskar Koch

IPC: C07C67/02 ,  C07C37/50 ,  C07C67/32 ,  C07C67/03 ,  C07C67/30

Abstract: The present invention relates to a method of producing a compound of formula (I) or a salt of a compound of formula (I). The invention also relates to a compound of formula (I) or a salt of a compound of formula (I) for use in a therapeutic method to achieve one or more therapeutic effects as well as for use in the treatment and/or prevention of certain diseases. Furthermore, the invention provides a pharmaceutical composition comprising one or more compound(s) of formula (I) or salt(s) of compound(s) of formula (I).