公开(公告)号：US10767198B2

公开(公告)日：2020-09-08

申请号：US15779214

申请日：2015-11-28

申请人： SYMRISE AG

发明人： Marco A. Fraatz ,  Holger Zorn ,  Johanna Rost ,  Michael Goldmann ,  Egon Gross ,  Jakob Ley ,  Katrin Geissler ,  Torsten Geissler ,  Michael Backes ,  Fabia Hentschel ,  Jens-Michael Hilmer

IPC分类号： C12P7/24 ,  C07C45/27 ,  C12N9/02

摘要： A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes having the same number of carbon atoms compared to the free and/or bound carboxylic acids or into the corresponding aldehydes having a reduced number of carbon atoms by one compared to the free and/or bound carboxylic acids and producing the biologically produced second intermediate containing these aldehydes; (f) treating the chemically produced second intermediate with an oxidizing agent of a chemical nature to convert the free and/or bound alcohols into the corresponding aldehydes; and optionally (g) removing interfering by-components from the fractions obtainable after step(s) (d) and/or (e) and/or (f).