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32 条记录 (耗时 0.022 秒)

    COMBINATION REMEDY
    1.
    发明申请
    COMBINATION REMEDY 有权

    公开(公告)号：US20220071933A1

    公开(公告)日：2022-03-10

    申请号：US17423400

    申请日：2019-01-18

    申请人： SYMRISE AG

    发明人： Jakob Ley ,  Veronika Somoza ,  Verena Stöger ,  Joachim Hans

    IPC分类号： A61K31/165 ,  A61K31/198 ,  A61K38/01 ,  A61K45/06 ,  A23L33/18 ,  A23L33/175

    摘要： The present invention primarily relates to a combination agent for reducing appetite and/or for providing a feeling of satiety and/or for reducing energy intake and/or for reducing body weight. In addition, the present invention relates to a medical use of the combination agent, in particular for the treatment of overweight and obesity and for the prevention of cardiovascular disease, stroke, diabetes, and joint damage and wear of the spine, and to a non-therapeutic use of the combination agent. In particular, the focus of the present invention is on the use of the combination agent to provide a feeling of satiety and/or to reduce energy intake and/or to reduce body weight. Finally, the present invention relates to the use of the combination agent for the preparation of an orally consumable preparation or food ingredient and an orally consumable preparation or food ingredient prepared therefrom.

    Method for producing branched aldehydes
    3.
    发明授权
    Method for producing branched aldehydes 有权

    公开(公告)号：US10767198B2

    公开(公告)日：2020-09-08

    申请号：US15779214

    申请日：2015-11-28

    申请人： SYMRISE AG

    发明人： Marco A. Fraatz ,  Holger Zorn ,  Johanna Rost ,  Michael Goldmann ,  Egon Gross ,  Jakob Ley ,  Katrin Geissler ,  Torsten Geissler ,  Michael Backes ,  Fabia Hentschel ,  Jens-Michael Hilmer

    IPC分类号： C12P7/24 ,  C07C45/27 ,  C12N9/02

    摘要： A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes having the same number of carbon atoms compared to the free and/or bound carboxylic acids or into the corresponding aldehydes having a reduced number of carbon atoms by one compared to the free and/or bound carboxylic acids and producing the biologically produced second intermediate containing these aldehydes; (f) treating the chemically produced second intermediate with an oxidizing agent of a chemical nature to convert the free and/or bound alcohols into the corresponding aldehydes; and optionally (g) removing interfering by-components from the fractions obtainable after step(s) (d) and/or (e) and/or (f).

    ORAL COMPOSITIONS
    9.
    发明申请
    ORAL COMPOSITIONS 有权
    口腔组成

    公开(公告)号：US20140234412A1

    公开(公告)日：2014-08-21

    申请号：US14179170

    申请日：2014-02-12

    申请人： Symrise AG

    发明人： Jakob Ley ,  Sabine Widder ,  Veronika Somoza ,  Barbara Rohm ,  Matthias Zaunschirm ,  Gerhard Krammer

    IPC分类号： A61K31/16 ,  A23K1/16 ,  A23L1/30

    CPC分类号： A23K20/105 ,  A23L33/10 ,  A23L33/30 ,  A61K31/16 ,  A61K31/164

    摘要： Suggested are new compositions for oral ingestion, comprising at least one active agent from the group of alkamides. The compositions which are orally ingested reduce the uptake of free fatty acids in the adipocytes and at the same time stimulate the release of serotonin and dopamine, which leads to a reduction of appetite, a feeling of satiety and a positive mood. In doing so, the new compositions are thus perfectly suitable to counteract any undesired gain of weight.

    摘要翻译： 建议的是用于口服摄取的新组合物，其包含至少一种来自该组烷酰胺的活性剂。 口服摄入的组合物降低脂肪细胞中游离脂肪酸的摄取量，同时刺激5-羟色胺和多巴胺的释放，这导致食欲降低，饱腹感和积极情绪。 因此，新组合物非常适合抵消任何不希望的重量增加。

    N-Nonanoylvanillylamine as an agent for reducing the appetite, as an agent for imparting a feeling of fullness and as a mood enhancer, and corresponding substance mixtures, orally consumable products and methods
    10.
    发明申请
    N-Nonanoylvanillylamine as an agent for reducing the appetite, as an agent for imparting a feeling of fullness and as a mood enhancer, and corresponding substance mixtures, orally consumable products and methods 审中-公开
    N-壬酰基乙烯胺作为减轻食欲的药剂，作为赋予丰满感的药剂和作为情绪增强剂的药剂，以及相应的物质混合物，口服消费品和方法

    公开(公告)号：US20130178534A1

    公开(公告)日：2013-07-11

    申请号：US13736414

    申请日：2013-01-08

    申请人： Symrise AG

    发明人： Jakob Ley ,  Gerhard Krammer ,  Veronika Somoza ,  Barbara Rohm ,  Mark Somoza

    IPC分类号： A61K31/165 ,  A61K45/06 ,  C07C233/22

    CPC分类号： A61K31/165 ,  A23L33/10 ,  A23L33/17 ,  A23L33/30 ,  A61K45/06 ,  C07C233/22

    摘要： There is described primarily N-nonanoylvanillylamine for use in a therapeutic method as (a) an agent for reducing the appetite and/or (b) an agent for imparting a feeling of fullness and/or (c) a mood enhancer, as well as the non-therapeutic use of N-nonanoylvanillylamine as (a) an agent for reducing the appetite and/or (b) an agent for imparting a feeling of fullness and/or (c) a mood enhancer. The non-therapeutic use of corresponding substance mixtures is also further described. Finally, the invention relates also to orally consumable products (in particular foodstuffs, feeds and medicaments) comprising N-nonanoylvanillylamine, wherein the N-nonanoylvanillylamine is present in a concentration that (a) reduces the appetite and/or (b) brings about a feeling of fullness and/or (c) enhances the mood, but which concentration is low.

    摘要翻译： 主要描述了用于治疗方法的N-壬酰基乙烯基胺，其为（a）用于降低食欲的药剂和/或（b）赋予饱胀感的药剂和/或（c）心境增强剂，以及 N-壬酰乙烯胺的非治疗用途为（a）降低食欲的药剂和/或（b）赋予饱胀感的药剂和/或（c）心境增强剂。 还进一步描述了相应物质混合物的非治疗用途。 最后，本发明还涉及包含N-壬酰基乙烯基胺的口服消耗品（特别是食品，饲料和药物），其中N-壬酰基乙烯基胺以（a）降低食欲和/或（b）产生 充满感和/或（c）增强情绪，但哪种浓度较低。