公开(公告)号：US20190367954A1

公开(公告)日：2019-12-05

申请号：US15779214

申请日：2015-11-28

Applicant: SYMRISE AG

Inventor： Mario FRAATZ ,  Holger ZORN ,  Johanna ROST ,  Michael GOLDMAN ,  Egon GROSS ,  Jakob LEY ,  Katrin GEISSLER ,  Torsten GEISSLER ,  Michael BACKES ,  Fabia HENTSCHEL ,  Jens-Michael HILMER

IPC: C12P7/24 ,  C07C45/27 ,  C12N9/02

Abstract: A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes having the same number of carbon atoms compared to the free and/or bound carboxylic acids or into the corresponding aldehydes having a reduced number of carbon atoms by one compared to the free and/or bound carboxylic acids and producing the biologically produced second intermediate containing these aldehydes; (f) treating the chemically produced second intermediate with an oxidizing agent of a chemical nature to convert the free and/or bound alcohols into the corresponding aldehydes; and optionally (g) removing interfering by-components from the fractions obtainable after step(s) (d) and/or (e) and/or (f).