公开(公告)号：US20190127314A1

公开(公告)日：2019-05-02

申请号：US16086686

申请日：2016-03-23

Applicant: SYMRISE AG

Inventor： Joachim HANS ,  Barbara LIEDER ,  Katrin GEISSLER ,  Fabia HENTSCHEL ,  Jakob Peter LEY ,  Veronika SOMOZA

IPC: C07C69/734 ,  A23L33/00 ,  A23L33/20 ,  A23L33/10 ,  A23L2/52 ,  A23L2/02 ,  A23G4/06 ,  A23G3/36 ,  A23C9/13 ,  A23C9/18 ,  A23C9/152

Abstract: The present invention particularly relates to new uses of compounds of formula (I) (as described herein) for inhibiting or reducing the absorption of free fatty acids in the small intestine, as well as a new compound of formula (I) as such, aroma compositions and new compositions comprising such a compound of formula (I). Further aspects of the present invention result from the patent claims and the subsequent description including the examples.

公开(公告)号：US20190367954A1

公开(公告)日：2019-12-05

申请号：US15779214

申请日：2015-11-28

Applicant: SYMRISE AG

Inventor： Mario FRAATZ ,  Holger ZORN ,  Johanna ROST ,  Michael GOLDMAN ,  Egon GROSS ,  Jakob LEY ,  Katrin GEISSLER ,  Torsten GEISSLER ,  Michael BACKES ,  Fabia HENTSCHEL ,  Jens-Michael HILMER

IPC: C12P7/24 ,  C07C45/27 ,  C12N9/02

Abstract: A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes having the same number of carbon atoms compared to the free and/or bound carboxylic acids or into the corresponding aldehydes having a reduced number of carbon atoms by one compared to the free and/or bound carboxylic acids and producing the biologically produced second intermediate containing these aldehydes; (f) treating the chemically produced second intermediate with an oxidizing agent of a chemical nature to convert the free and/or bound alcohols into the corresponding aldehydes; and optionally (g) removing interfering by-components from the fractions obtainable after step(s) (d) and/or (e) and/or (f).

公开(公告)号：US20190194707A1

公开(公告)日：2019-06-27

申请号：US15764644

申请日：2016-09-30

Applicant: SYMRISE AG ,  LEIBNITZ-INSTITUT FUER PFLANZENBIOCHEMIE

Inventor： Ludger A. WESSJOHANN ,  Susann HERRMANN ,  Martin DIPPE ,  Torsten GEISSLER ,  Katrin GEISSLER ,  Jakob Peter LEY

IPC: C12P17/06 ,  C12P7/42 ,  C12P7/22 ,  C12P17/10 ,  C12P7/26 ,  C12N9/10 ,  C12N9/02

CPC classification number: C12P17/06 ,  C12N9/0071 ,  C12N9/1007 ,  C12P7/22 ,  C12P7/26 ,  C12P7/42 ,  C12P17/10 ,  C12Y114/14001 ,  C12Y201/01

Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.