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公开(公告)号：US20240130408A1
公开(公告)日：2024-04-25
申请号：US18547173
申请日：2021-02-22
Applicant: SYMRISE AG
Inventor： Tobias TRAPP , Torsten GEISSLER , Jakob Peter LEY , Jens KOCH , Gerhard KRAMMER , Suzan YALMAN , Marco FRAATZ , Holger ZORN
Abstract: The present invention primarily relates to a process for production of one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulphuric compounds, the process comprising providing a culture medium comprising one or more components supporting growth of a fungus from the phylum Basidiomycota and being convertable to one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulfur aroma compounds; cultivating a fungus from the phylum Basidiomycota in or on the culture medium under conditions that support the growth of the fungus and formation of the one or more flavourings, and optionally recovering the one or more flavourings.
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公开(公告)号：US20220202695A1
公开(公告)日：2022-06-30
申请号：US17611432
申请日：2020-05-15
Applicant: SYMRISE AG
Inventor： Holger ZORN , Svenja SOMMER , Nadine SELLA , Christine SCHLERING , Martin RÜHL , Marco FRAATZ , Julia BÜTTNER , Tobias TRAPP , Gerhard KRAMMER , Torsten GEISSLER
IPC: A61K8/9789 , C12P7/26 , C12P7/04
Abstract: The present invention relates to a biocatalytic process for producing an aroma substance or a mixture of aroma substances, comprising the steps of: providing a conversion medium comprising a plant component of the gooseber-ry family, the rose family and/or the grapevine family; contacting the conversion medium with at least one fungus from the division of stander fungi capable of forming an aroma substance or a mixture of aroma sub-stances on the conversion medium; converting the plant component to the aroma substance or mixture of aroma substances with the aid of the fungus; and optionally recovering the aroma substance or mixture of aroma substances, wherein the aroma substance or mixture of aroma substances preferably com-prises at least one compound selected from the group consisting of 2-octanone, 2-nonanone, 2-undecanone, linalool oxides, benzaldehyde, geraniol, 2-octanol, methylanthranilate, 2-aminobenzaldehyde and linalool.
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公开(公告)号：US20190367954A1
公开(公告)日：2019-12-05
申请号：US15779214
申请日：2015-11-28
Applicant: SYMRISE AG
Inventor： Mario FRAATZ , Holger ZORN , Johanna ROST , Michael GOLDMAN , Egon GROSS , Jakob LEY , Katrin GEISSLER , Torsten GEISSLER , Michael BACKES , Fabia HENTSCHEL , Jens-Michael HILMER
Abstract: A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes having the same number of carbon atoms compared to the free and/or bound carboxylic acids or into the corresponding aldehydes having a reduced number of carbon atoms by one compared to the free and/or bound carboxylic acids and producing the biologically produced second intermediate containing these aldehydes; (f) treating the chemically produced second intermediate with an oxidizing agent of a chemical nature to convert the free and/or bound alcohols into the corresponding aldehydes; and optionally (g) removing interfering by-components from the fractions obtainable after step(s) (d) and/or (e) and/or (f).
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4.发明申请公开(公告)号：US20190194707A1
公开(公告)日：2019-06-27
申请号：US15764644
申请日：2016-09-30
Applicant: SYMRISE AG , LEIBNITZ-INSTITUT FUER PFLANZENBIOCHEMIE
Inventor： Ludger A. WESSJOHANN , Susann HERRMANN , Martin DIPPE , Torsten GEISSLER , Katrin GEISSLER , Jakob Peter LEY
CPC classification number: C12P17/06 , C12N9/0071 , C12N9/1007 , C12P7/22 , C12P7/26 , C12P7/42 , C12P17/10 , C12Y114/14001 , C12Y201/01
Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.
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Patent Agency Ranking
公开(公告)号：US20230407349A1
公开(公告)日：2023-12-21
申请号：US17910649
申请日：2020-03-12
Applicant: SYMRISE AG
Inventor： Torsten GEISSLER , Jakob Peter LEY , Michael BACKES , Christoph HARMS , Uwe BORNSCHEUER , Kathleen BALKE , Holger ZORN , Marco Alexander FRAATZ , Andreas HAMMER
CPC classification number: C12P7/40 , C12P7/24 , C12N15/63 , C12Y113/11 , C12Y102/01003
Abstract: The present invention relates to biotechnological methods for the production of saturated as well as unsaturated aldehydes, and mixtures thereof using at least one alpha-dioxygenase and at least one aldehyde dehydrogenase. The method may be carried out either fermentatively or enzymatically. Furthermore, the present invention relates to a vector system, as well as sequences and recombinant microorganisms encoding the enzymes that can be used to produce the aldehydes and mixtures according to the invention. Further, the present invention relates to compositions obtained by the methods according to the present invention.
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公开(公告)号：US20230279451A1
公开(公告)日：2023-09-07
申请号：US17763735
申请日：2020-09-25
Applicant: SYMRISE AG
Inventor： Torsten GEISSLER , Jakob Peter LEY , Bastian ZIRPEL
CPC classification number: C12P17/04 , C12N9/1007 , C12N9/1085 , C12Y205/01006 , A23L27/33
Abstract: The present invention relates to a biocatalytical method for manufacturing of homoeriodictyol dihydrochalcone and/or hesperetin dihydrochalcone by providing at least one first biocatalyst system for the hydroxylation of phloretin and/or its glycosides as well as at least one second biocatalyst for the methylation of 3-hydroxyphloretin. Further disclosed are microorganisms capable of producing such biocatalysts as well as sequences encoding the biocatalysts. Furthermore, the present invention relates to the use of a mixture obtained by a method as disclosed in the present invention and to specific compositions suitable as sweetness enhancers and/or flavouring agents.
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公开(公告)号：US20240298686A1
公开(公告)日：2024-09-12
申请号：US18258417
申请日：2020-12-21
Applicant: SYMRISE AG
Inventor： Torsten GEISSLER , Jakob Peter LEY , Egon GROSS , Katharina REICHELT , Thomas RIESS , Tom SOMERS
Abstract: The present invention relates to the use of naringenin for improving the taste quality of phloretin. Additionally, the present invention relates to a method for improving the taste quality of phloretin. Furthermore, the invention relates to aroma compositions containing naringenin and phloretin as well as semi-finished and finished products containing the aroma compositions.
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公开(公告)号：US20240225063A9
公开(公告)日：2024-07-11
申请号：US18547173
申请日：2021-02-22
Applicant: SYMRISE AG
Inventor： Tobias TRAPP , Torsten GEISSLER , Jakob Peter LEY , Jens KOCH , Gerhard KRAMMER , Suzan YALMAN , Marco FRAATZ , Holger ZORN
Abstract: The present invention primarily relates to a process for production of one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulphuric compounds, the process comprising providing a culture medium comprising one or more components supporting growth of a fungus from the phylum Basidiomycota and being convertable to one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulfur aroma compounds; cultivating a fungus from the phylum Basidiomycota in or on the culture medium under conditions that support the growth of the fungus and formation of the one or more flavourings, and optionally recovering the one or more flavourings.
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公开(公告)号：US20190289886A1
公开(公告)日：2019-09-26
申请号：US15780346
申请日：2015-12-01
Applicant: SYMRISE AG
Inventor： Johannes KIEFL , Susanne PAETZ , Jakob LEY , Gerhard KRAMMER , Thomas RIESS , Kathrin LANGER , Günter KINDEL , Morine VERWOHLT , Torsten GEISSLER , Egon GROSS
IPC: A23L27/10 , A23L2/56 , A23L27/30 , A23L2/60 , A23L27/00 , A61K9/00 , A61K47/26 , A61K47/10 , A61K47/24
Abstract: Proposed are mixtures of substances containing (a) phloretin, (b) naringenin, (c) at least one further sweet substance other than phloretin and naringenin, and optionally (d) at least one flavoring substance.
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