公开(公告)号：US20180299381A1

公开(公告)日：2018-10-18

申请号：US15951393

申请日：2018-04-12

Applicant: SYSMEX CORPORATION

Inventor： Shohei MATSUMOTO ,  Shruti SHARMA

IPC: G01N21/64

Abstract: Disclosed is a fluorescence image analyzing apparatus including a light source that emits light to a sample including a plurality of cells labeled with a fluorescent dye at a target site, an imaging unit that captures a fluorescence image of each of the cells that emit fluorescence by being irradiated with the light, a processing unit that processes the fluorescence image captured by the imaging unit, and a display unit that displays the fluorescence image processed by the processing unit. The processing unit performs an extraction process of extracting, for each cell, a plurality of bright spots in the fluorescence image including the target site, a changing process of changing a pixel value of each of the plurality of extracted bright spots based on the pixel value of each bright spot, and a display process of displaying the fluorescence image whose pixel value is changed on the display unit.

公开(公告)号：US20190049379A1

公开(公告)日：2019-02-14

申请号：US16059340

申请日：2018-08-09

Applicant: SYSMEX CORPORATION

Inventor： Yusuke KONISHI ,  Kazuhiro YAMADA ,  Shohei MATSUMOTO

IPC: G01N21/64 ,  G01J3/28 ,  C12Q1/6809

Abstract: Disclosed is a sample analyzer that includes: a measurement unit configured to apply light to a measurement specimen containing a plurality of kinds of target substances each labeled with fluorescence, and detect a plurality of kinds of fluorescences having different wavelengths; and a processing unit configured to analyze the plurality of kinds of target substances based on a detection result from the measurement unit, and information, on a color of fluorescence, which is set to be variable so as to correspond to the plurality of kinds of target substances.

公开(公告)号：US20180299382A1

公开(公告)日：2018-10-18

申请号：US15951562

申请日：2018-04-12

Applicant: SYSMEX CORPORATION

Inventor： Kazuhiro YAMADA ,  Shohei MATSUMOTO ,  Yusuke KONISHI

IPC: G01N21/64

Abstract: Disclosed is a fluorescence image analyzing apparatus including a light source that emits light to a sample including a plurality of cells labeled with a fluorescent dye at a target site, an imaging unit that captures a fluorescence image of each of the cells that emit fluorescence by being irradiated with the light, a fluorescence image of the cell, and a processing unit that processes the fluorescence image captured by the imaging unit to acquire a bright spot pattern of fluorescence in the fluorescence image. The processing unit selects a reference pattern corresponding to a measurement item of the sample from a plurality of reference patterns corresponding to a plurality of measurement items and generates information used for determination of the sample based on the bright spot pattern of fluorescence in the fluorescence image and the selected reference pattern.

公开(公告)号：US20210010925A1

公开(公告)日：2021-01-14

申请号：US17035968

申请日：2020-09-29

Applicant: SYSMEX CORPORATION

Inventor： Tomoya HAYASHI ,  Shohei MATSUMOTO ,  Kazuhiro YAMADA

IPC: G01N15/14

Abstract: A flow cytometer, in which detection of light generated from a particle is less likely to be affected by change in a flow velocity of a liquid flowing in a flow cell, is provided. The flow cytometer includes: a flow cell (10) in which a liquid flows; a liquid sending unit (40) configured to send the liquid into the flow cell (10); a controller (300) configured to obtain information related to a flow velocity of the liquid flowing in the flow cell (10); a light source (121) configured to irradiate the liquid flowing in the flow cell (10) with light; and a detector (162) configured to detect light generated from a particle in the liquid irradiated with light. The controller (300) changes a liquid sending condition for the liquid sending unit (40), based on the obtained information related to the flow velocity.

公开(公告)号：US20200249165A1

公开(公告)日：2020-08-06

申请号：US16792483

申请日：2020-02-17

Applicant: SYSMEX CORPORATION

Inventor： Shohei MATSUMOTO ,  Shruti SHARMA

IPC: G01N21/64 ,  G06T5/00 ,  C12Q1/6841 ,  G06T7/00 ,  G02B21/00

Abstract: Disclosed is a fluorescence image analyzing apparatus including a light source that emits light to a sample including a plurality of cells labeled with a fluorescent dye at a target site, an imaging unit that captures a fluorescence image of each of the cells that emit fluorescence by being irradiated with the light, a processing unit that processes the fluorescence image captured by the imaging unit, and a display unit that displays the fluorescence image processed by the processing unit. The processing unit performs an extraction process of extracting, for each cell, a plurality of bright spots in the fluorescence image including the target site, a changing process of changing a pixel value of each of the plurality of extracted bright spots based on the pixel value of each bright spot, and a display process of displaying the fluorescence image whose pixel value is changed on the display unit.

公开(公告)号：US20190301993A1

公开(公告)日：2019-10-03

申请号：US16365964

申请日：2019-03-27

Applicant: SYSMEX CORPORATION

Inventor： Shohei MATSUMOTO ,  Tomoya HAYASHI

IPC: G01N15/14

Abstract: The present invention is to provide a flow cytometer comprising: flow cell; a liquid feeding unit for feeding a liquid different from a sample liquid containing sample particles to the flow cell; a sample liquid feeding unit for feeding the sample liquid to the flow cell after the liquid is sent to the flow cell; and a detector for detecting the sample particles flowing through the flow cell.

公开(公告)号：US20190049357A1

公开(公告)日：2019-02-14

申请号：US16058321

申请日：2018-08-08

Applicant: SYSMEX CORPORATION

Inventor： Shohei MATSUMOTO ,  Chikako MURATA ,  Kenichiro SUZUKI

IPC: G01N15/14 ,  G06K9/00

Abstract: In view of such problems, the present invention provides a sample processing apparatus, a sample processing system, and a method of calculating measurement time, which allow an operator to efficiently capture images of cells. This invention relates to a sample processing apparatus 10 for measuring and analyzing a measurement sample 22. The sample processing apparatus 10 includes a light source 121 that irradiates light to the measurement sample 22, an imaging unit 154 that images light generated from the measurement sample 22 by irradiation with light, concentration information of cells included in the measurement sample 22 And a processing unit 11 that calculates a time required for cell imaging. The required time includes the time required for the processing of the image captured by the imaging unit 154 and the time required for the analysis of the image processed by the imaging unit 154.

公开(公告)号：US20180315176A1

公开(公告)日：2018-11-01

申请号：US15964976

申请日：2018-04-27

Applicant: SYSMEX CORPORATION

Inventor： Shruti SHARMA ,  Shohei MATSUMOTO

IPC: G06T5/50 ,  G06T7/00 ,  G06T11/60 ,  G06T5/00

CPC classification number: G06T5/50 ,  G06T5/001 ,  G06T5/005 ,  G06T7/0012 ,  G06T11/60 ,  G06T2200/24 ,  G06T2207/10056 ,  G06T2207/30024

Abstract: An image display apparatus 120 for imaging and displaying a test substance contained in a sample 111 includes an imaging unit 200 for imaging a test substance, an image processing unit 121 for generating an image 61 for display including an additional image 11c in which the pixel value of each pixel is set in uneven distribution added to at least part of the captured image 11 obtained by the imaging unit 200 and a region 21 of the test substance, and a display unit 123 for displaying the image 61 generated by the image processing unit 121.