公开(公告)号：US06449509B1

公开(公告)日：2002-09-10

申请号：US09651623

申请日：2000-08-30

申请人： Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Said Mortazavi

发明人： Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Said Mortazavi

IPC分类号： A61N1365

CPC分类号： A61N1/36521

摘要： An implantable cardiac device that is adapted to periodically measure a body parameter, such as transthoracic impedance, at time periods selected so that the body parameter is primarily indicative of the respiration of the patient. In this way, a ventilation parameter, such as minute ventilation, can be reconstructed from the signals without requiring filtering of the sampled signals. In one embodiment, the implantable cardiac device measures transthoracic impedance during each quiescent period of the heart and thereby obtains a plurality of transthoracic impedance data points which are then used to reconstruct a ventilation signal. As the transthoracic impedance data points are obtained during the quiescent period, the contribution of the heart to the resulting transthoracic impedance measurement can be ignored and the resulting measurements are indicative of the action of the heart. In another embodiment, the implantable cardiac device obtains transthoracic impedance signals during the zero crossings of the measured impedance signal. As the transthoracic signal is measured during the zero crossing of the measured impedance signal, the heart component of the signal is filtered out.

摘要翻译： 一种可植入心脏装置，其适于在所选择的时间周期周期性地测量身体参数，例如经胸阻抗，使得身体参数主要指示患者的呼吸。 以这种方式，可以从信号重建诸如分钟通气的通气参数，而不需要对采样信号进行滤波。 在一个实施例中，可植入心脏装置在心脏的每个静止期间测量经胸阻抗，从而获得多个经胸阻抗数据点，然后将其用于重建通气信号。 由于在静止期间获得经胸阻抗数据点，所以可以忽略心脏对所得经胸阻抗测量的贡献，并且所得到的测量值表示心脏的作用。 在另一个实施例中，可植入心脏装置在测量的阻抗信号的过零点期间获得经胸阻抗信号。 由于在测量的阻抗信号的过零点期间测量经胸廓信号，所以信号的心脏分量被滤除。

公开(公告)号：US5509926A

公开(公告)日：1996-04-23

申请号：US384167

申请日：1995-02-06

申请人： Said Mortazavi ,  Gene A. Bornzin

发明人： Said Mortazavi ,  Gene A. Bornzin

IPC分类号： A61N1/365

CPC分类号： A61N1/36542

摘要： A pyroelectric suppressor circuit for preventing undesirable thermally induced signals generated by a piezoelectric physical activity sensor from reaching processor circuitry within an implantable medical device is provided. The thermally induced signals typically have frequencies below a frequency in the range from about 0.1 mHz to about 10 mHz. The suppressor circuit provides a high-pass filter that rejects signals that have frequencies associated with thermally induced signals. Signals having frequencies greater than a frequency in the range from about 0.1 mHz to about 10 mHz, which correspond to patient activity, are passed on to processing circuitry of the implantable medical device.

摘要翻译： 提供了一种用于防止由压电物理活动传感器产生的不期望的热诱导信号到达可植入医疗装置内的处理器电路的热电抑制电路。 热感应信号通常具有低于约0.1mHz至约10mHz范围内的频率的频率。 抑制电路提供高通滤波器，其抑制具有与热诱导信号相关联的频率的信号。 频率大于约0.1mHz至约10mHz的频率的对应于患者活动的频率的信号被传递到可植入医疗装置的处理电路。

公开(公告)号：US06269264B1

公开(公告)日：2001-07-31

申请号：US09325312

申请日：1999-06-03

申请人： Robert R. Weyant ,  Jason A. Sholder ,  Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Said Mortazavi

发明人： Robert R. Weyant ,  Jason A. Sholder ,  Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Said Mortazavi

IPC分类号： A61B505

CPC分类号： A61N1/36521

摘要： Methods and apparatus are provided for measuring the impedance of a patient's body. Pulse generating circuitry within a rate-responsive pacemaker is used to generate an impedance measurement signal that is applied to the body of the patient with conventional pacemaker leads. The impedance measurement signal contains a series of multiphasic impedance measurement waveforms, which have no net DC value and zero value after second integration. The impedance measurement signal allows the impedance of the body to be measured without interfering with external cardiac monitoring equipment such as electrocardiogram machines.

摘要翻译： 提供了用于测量患者身体阻抗的方法和装置。 速率响应起搏器内的脉冲发生电路用于产生用常规起搏器引线施加到患者身体的阻抗测量信号。 阻抗测量信号包含一系列多相阻抗测量波形，其在第二次积分后不具有净DC值和零值。 阻抗测量信号允许测量身体的阻抗，而不会干扰外部心脏监测设备，如心电图仪。

公开(公告)号：US6044294A

公开(公告)日：2000-03-28

申请号：US766636

申请日：1996-12-13

申请人： Said Mortazavi ,  Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Jason A. Sholder ,  Robert R. Weyant

发明人： Said Mortazavi ,  Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Jason A. Sholder ,  Robert R. Weyant

IPC分类号： A61N1/365 ,  A61B5/05

CPC分类号： A61N1/36521

摘要： Methods and apparatus are provided for measuring the impedance of a patient's body. Pulse generating circuitry within a rate-responsive pacemaker is used to generate an impedance measurement signal that is applied to the body of the patient with conventional pacemaker leads. The impedance measurement signal contains a series of multiphasic impedance measurement waveforms, which have no net DC value and zero value after second integration. The impedance measurement signal allows the impedance of the body to be measured without interfering with external cardiac monitoring equipment such as electrocardiogram machines.

摘要翻译： 提供了用于测量患者身体阻抗的方法和装置。 速率响应起搏器内的脉冲发生电路用于产生用常规起搏器引线施加到患者身体的阻抗测量信号。 阻抗测量信号包含一系列多相阻抗测量波形，其在第二次积分后不具有净DC值和零值。 阻抗测量信号允许测量身体的阻抗，而不会干扰外部心脏监测设备，如心电图仪。

公开(公告)号：US09017341B2

公开(公告)日：2015-04-28

申请号：US13352005

申请日：2012-01-17

申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

IPC分类号： A61B19/00 ,  A61N1/05 ,  A61N1/375 ,  A61N1/372 ,  A61N1/365

CPC分类号： A61N1/059 ,  A61N1/0573 ,  A61N1/36521 ,  A61N1/37288 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.

摘要翻译： 无引线心脏内心脏医疗装置（LIMD）包括被配置为锚定在心脏的第一腔室的第一壁部分内的电极组件。 电极组件包括具有第一固定螺旋线的电极主体，从主体延伸的电极线段和位于电极线段上的第一段终止触点。 该装置还包括壳体组件，其构造成锚固在心脏的第二腔室的第二壁部分内。 壳体组件包括具有第二固定螺旋的主体，从主体延伸的壳体线段和位于壳体线段上的第二段终止触点。 该装置还包括连接器块，其通过保持第一和第二段终止触点将电极线段电连接到壳体线段。

公开(公告)号：US09008777B2

公开(公告)日：2015-04-14

申请号：US13529226

申请日：2012-06-21

申请人： Ali Dianaty ,  Gabriel A. Mouchawar ,  Gene A. Bornzin ,  John W. Poore ,  Xiaoyi Min ,  Zoltan Somogyi ,  Richard Williamson

发明人： Ali Dianaty ,  Gabriel A. Mouchawar ,  Gene A. Bornzin ,  John W. Poore ,  Xiaoyi Min ,  Zoltan Somogyi ,  Richard Williamson

IPC分类号： A61N1/00 ,  A61N1/375 ,  A61N1/368

CPC分类号： A61N1/3756 ,  A61B5/042 ,  A61N1/362 ,  A61N1/368 ,  Y10T29/49002

摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.

摘要翻译： 无引线植入式医疗装置（LIMD）包括由电池和端盖形成的壳体。 端盖的近端形成LIMD近端，并且电池壳体的远端形成LIMD远端。 非导电耦合器将电池壳体的终端机械地固定到端盖的配合端，同时保持电池壳体和端盖电气分离。 第一电极从端盖的近端突出。 心脏内（IC）装置延伸部从电池盒的远端伸出。 该延伸部包括电连接到电池壳体的第二电极。 第二电极远离LIMD远端。 电子模块位于端盖的内部空腔内并与第一和第二电极连通。

公开(公告)号：US08731665B1

公开(公告)日：2014-05-20

申请号：US11923286

申请日：2007-10-24

申请人： Xiaoyi Min ,  Laleh Jalali ,  Steve Koh ,  Gene A. Bornzin ,  Euljoon Park

发明人： Xiaoyi Min ,  Laleh Jalali ,  Steve Koh ,  Gene A. Bornzin ,  Euljoon Park

IPC分类号： A61N1/00

CPC分类号： A61N1/365 ,  A61N1/36535

摘要： Systems and methods are provided for detecting the orientation and/or movement of a patient having an implantable cardiac stimulation device and evaluating whether a change in the patient's cardiac activity can be at least in part due to a change in the patient's orientation. In one particular embodiment, signals from an orientation sensor and/or a pressure sensor are evaluated to determine static positional orientation of the patient and determine based on the static orientation whether the patient's cardiac activity is abnormal.

摘要翻译： 提供了用于检测具有可植入心脏刺激装置的患者的取向和/或运动的系统和方法，并且评估患者的心脏活动的变化是否可以至少部分地由于患者取向的改变而变化。 在一个特定实施例中，评估来自定向传感器和/或压力传感器的信号以确定患者的静态位置取向，并且基于静态取向来确定患者的心脏活动是否异常。

公开(公告)号：US08700181B2

公开(公告)日：2014-04-15

申请号：US13352101

申请日：2012-01-17

申请人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi ,  Didier Theret

发明人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi ,  Didier Theret

IPC分类号： A61N1/362

CPC分类号： A61N1/059 ,  A61N1/0573 ,  A61N1/3684 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device (LIMD) configured to be implanted entirely within a heart of a patient includes a housing configured to be securely attached to an interior wall portion of a chamber of the heart, and a stabilizing intra-cardiac (IC) device extension connected to the housing. The stabilizing IC device extension may include a stabilizer arm, and/or an appendage arm, or an elongated body or a loop member configured to be passively secured within the heart.

摘要翻译： 被配置为完全植入患者心脏的无引线心脏内心脏医疗装置（LIMD）包括被构造成可靠地附接到心脏室的内壁部分的壳体，以及稳定心脏内（IC） 设备扩展连接到外壳。 稳定IC装置延伸部可以包括稳定器臂和/或附肢臂，或者被配置为被动地固定在心脏内的细长主体或环形构件。

公开(公告)号：US08634912B2

公开(公告)日：2014-01-21

申请号：US13352136

申请日：2012-01-17

申请人： Gene A. Bornzin ,  Gabriel A. Mouchawar ,  Xiaoyi Min ,  John W. Poore ,  Edward Karst ,  Richard Samade ,  Zoltan Somogyi ,  Didier Theret

发明人： Gene A. Bornzin ,  Gabriel A. Mouchawar ,  Xiaoyi Min ,  John W. Poore ,  Edward Karst ,  Richard Samade ,  Zoltan Somogyi ,  Didier Theret

IPC分类号： A61N1/362

CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N1/0573 ,  A61N1/3622 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device includes a housing that is configured to be implanted entirely within a single local chamber of the heart. A first electrode is provided on the housing at a first position such that when the housing is implanted in the local chamber, the first electrode engages the local wall tissue at a local activation site within the conduction network of the local chamber. An intra-cardiac extension is coupled to the housing and configured to extend from the local chamber into an adjacent chamber of the heart. A stabilization arm of the intra-cardiac extension engages the adjacent chamber. A second electrode on the intra-cardiac extension engages distal wall tissue at a distal activation site within the conduction network of the adjacent chamber.

摘要翻译： 无引线心脏内心脏医疗设备包括被配置为完全植入心脏的单个局部腔室内的壳体。 第一电极在第一位置处设置在壳体上，使得当壳体被植入局部腔室时，第一电极在局部腔室的传导网络内的局部激活位置接合局部壁组织。 心脏内延伸部分耦合到壳体并且构造成从局部腔室延伸到心脏的相邻室中。 心脏内延伸部的稳定臂与相邻的腔室相接合。 心脏延伸部分上的第二个电极与相邻腔室的传导网络内的远端活化位点处的远端壁组织接合。

公开(公告)号：US20130296661A1

公开(公告)日：2013-11-07

申请号：US13464590

申请日：2012-05-04

申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

IPC分类号： A61B5/0205 ,  A61B5/103 ,  A61B5/145 ,  A61B5/0215 ,  A61B5/0402

CPC分类号： A61B5/0205 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14532

摘要： An implantable physiologic sensor assembly is configured to be implanted within a patient. The assembly includes a module that houses an internal operative chamber, and a flexible pressure-detecting member connected to the module. The module and the pressure-detecting member are separated before implantation into the patient. At least a first end of the pressure-detecting member is configured to be inserted into an artery of the patient and a second end of the pressure-detecting member is connected to the module. The module is configured to be subcutaneously positioned within the patient.

摘要翻译： 可植入生理传感器组件被配置为植入患者体内。 组件包括容纳内部操作室的模块和连接到模块的柔性压力检测构件。 模块和压力检测构件在植入之前被分离到患者体内。 压力检测构件的至少第一端构造成插入到患者的动脉中，并且压力检测构件的第二端连接到模块。 该模块被配置为皮下置于患者体内。