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    USE OF TAM RECEPTOR INHIBITORS AS IMMUNOENHANCERS AND TAM ACTIVATORS AS IMMUNOSUPPRESSORS
    2.
    发明申请
    USE OF TAM RECEPTOR INHIBITORS AS IMMUNOENHANCERS AND TAM ACTIVATORS AS IMMUNOSUPPRESSORS 审中-公开

    公开(公告)号：US20190134193A1

    公开(公告)日：2019-05-09

    申请号：US16059662

    申请日：2018-08-09

    申请人： SALK INSTITUTE FOR BIOLOGICAL STUDIES

    发明人： Carla V. Rothlin ,  Greg E. Lemke

    IPC分类号： A61K39/395 ,  A61K31/519 ,  A61K31/4196

    摘要： This disclosure concerns compositions and methods for immunoenhancement and/or immunosuppression. In certain embodiments, the disclosure concerns methods of using a TAM receptor inhibitor for immunoenhancement, for example as a vaccine adjuvant, for the treatment of sepsis, or for treating an immunocompromised subject. Also disclosed are methods of screening for immunoenhancing agents. In other embodiments, the disclosure concerns methods of using a TAM receptor agonist for immunosuppression, for example as a treatment for an autoimmune disorder, for the treatment of an allergy, or for treating graft-versus-host disease in a subject. Also disclosed are methods of screening for immunosuppressive agents.

    REGULATING THE INTERACTION BETWEEN TAM LIGANDS AND LIPID MEMBRANES WITH EXPOSED PHOSPHATIDYL SERINE
    4.
    发明申请
    REGULATING THE INTERACTION BETWEEN TAM LIGANDS AND LIPID MEMBRANES WITH EXPOSED PHOSPHATIDYL SERINE 审中-公开
    调节TAM配体和带有暴露的磷脂酰丝氨酸的脂质膜之间的相互作用

    公开(公告)号：US20150164800A1

    公开(公告)日：2015-06-18

    申请号：US14416801

    申请日：2013-07-23

    申请人： Salk Institute for Biological Studies ,  Xetrios Therapeutics, Inc.

    发明人： Greg E. Lemke ,  Lawrence C. Fritz ,  Benedikt Vollrath ,  Carla V. Rothlin

    IPC分类号： A61K9/127 ,  C12Q1/02

    CPC分类号： C07K16/18 ,  A61K9/1275 ,  A61K31/444 ,  A61K38/17 ,  A61K38/1761 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6911 ,  A61K2039/505 ,  C07K16/249 ,  C07K2317/76 ,  C12N2740/16011 ,  C12Q1/025 ,  C12Q1/701 ,  G01N33/56983 ,  G01N2800/24

    摘要： The present disclosure provides methods for modulating the interaction between a TAM ligand and a lipid membrane containing phosphatidyl serine (PtdSer). In one example, such methods use a TAM receptor agonist having a PtdSer-containing lipid bilayer membrane with Gas6 and/or Protein S bound to the membrane to activate signaling from one or more TAM receptors and treat an autoimmune disease. In another example, methods are provided for treating a subject with a pathological condition characterized by overactivation of TAM signaling and/or reduction in Type I IFN response, such as infection by an enveloped virus, by use of agents that decrease the interaction between a TAM ligand and PtdSer. Also provided are methods for classifying a virus as susceptible to anti-TAM therapy. Methods of identifying an agent that blocks virus infectivity are also provided.

    摘要翻译： 本公开提供了调节TAM配体和含有磷脂酰丝氨酸（PtdSer）的脂质膜之间的相互作用的方法。 在一个实例中，这样的方法使用具有含PtdSer的脂质双层膜的TAM受体激动剂，其具有与膜结合的Gas6和/或蛋白S以激活来自一种或多种TAM受体的信号传导并治疗自身免疫性疾病。 在另一个实例中，提供了用于治疗患有TAM信号过度活化和/或减少I型IFN应答（例如包膜病毒感染）的病理状态的受试者的方法，通过使用减少TAM之间相互作用的试剂 配体和PtdSer。 还提供了将病毒分类为易于进行抗TAM治疗的方法。 还提供了鉴定阻断病毒感染性的药剂的方法。