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公开(公告)号：US09046699B2
公开(公告)日：2015-06-02
申请号：US13418661
申请日：2012-03-13
IPC分类号： G02C7/04
摘要： A contact lens incorporating one or more dynamic fluid zones fabricated from a material that is readily deformable under eyelid pressure during blinking allows for the delivery of one or more agents to the eye, dynamic cosmetic eye enhancement, and/or dynamic rotational misalignment correction. The one or more agents may include therapeutic agents, nutritional agents and pharmacological agents.
摘要翻译： 包含一个或多个动态流体区域的隐形眼镜，其由在闪烁期间在眼睑压力下容易变形的材料制成，允许将一种或多种药剂递送至眼睛，动态化妆眼睛增强和/或动态旋转未对准校正。 一种或多种药剂可以包括治疗剂，营养剂和药理学试剂。
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公开(公告)号：US20130242255A1
公开(公告)日：2013-09-19
申请号：US13418661
申请日：2012-03-13
摘要： A contact lens incorporating one or more dynamic fluid zones fabricated from a material that is readily deformable under eyelid pressure during blinking allows for the delivery of one or more agents to the eye, dynamic cosmetic eye enhancement, and/or dynamic rotational misalignment correction. The one or more agents may include therapeutic agents, nutritional agents and pharmacological agents.
摘要翻译： 包含一个或多个动态流体区域的隐形眼镜，其由在闪烁期间在眼睑压力下容易变形的材料制成，允许将一种或多种药剂递送至眼睛，动态化妆眼睛增强和/或动态旋转未对准校正。 一种或多种药剂可以包括治疗剂，营养剂和药理学试剂。
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公开(公告)号：US20140063445A1
公开(公告)日：2014-03-06
申请号：US13598722
申请日：2012-08-30
IPC分类号： G02C7/04
摘要： A contact lens incorporating one or more compliant dynamic translation zones fabricated from a material that is readily deformable under eyelid pressure during blinking and which allows for the control over translation of the contact lens on the eye. The one or more compliant dynamic translation zones provide for the comfortable relative movement of the contact lens over the eye.
摘要翻译： 一种隐形眼镜，其包括由在闪光期间在眼睑压力下容易变形的材料制成的一个或多个顺应性动态平移区，并且允许控制隐形眼镜在眼睛上的平移。 一个或多个柔顺的动态平移区提供隐形眼镜在眼睛上的舒适的相对运动。
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公开(公告)号：US09823493B2
公开(公告)日：2017-11-21
申请号：US13598722
申请日：2012-08-30
摘要： A contact lens incorporating one or more compliant dynamic translation zones fabricated from a material that is readily deformable under eyelid pressure during blinking and which allows for the control over translation of the contact lens on the eye. The one or more compliant dynamic translation zones provide for the comfortable relative movement of the contact lens over the eye.
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5.发明申请公开(公告)号：US20090105814A1
公开(公告)日：2009-04-23
申请号：US12249388
申请日：2008-10-10
申请人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
发明人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946
摘要： A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.
摘要翻译： 描述了通过使用由保持器固定的环形或相邻组织的一个或多个点进行重新形成二尖瓣环的治疗二尖瓣反流的系统和方法。 该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。 第一个是具有可脱垂或弯曲的尖端的交叉导管。 第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。 第三，折叠装置然后用于在二尖瓣环的亚瓣膜区域进行。肿。 第四，通过打浆装置展开具有可变形端部的“C”形保持器，以便将复制的组织保持在复制形式中。 经口途径可用于将二尖瓣心房侧的组织挽留并保留，以减少二尖瓣反流。
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6.发明授权公开(公告)号：US08226709B2
公开(公告)日：2012-07-24
申请号：US12249388
申请日：2008-10-10
申请人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
发明人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946
摘要： A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.
摘要翻译： 描述了通过使用由保持器固定的环形或相邻组织的一个或多个点进行重新形成二尖瓣环的治疗二尖瓣反流的系统和方法。 该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。 第一个是具有可脱垂或弯曲的尖端的交叉导管。 第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。 第三，折叠装置然后用于在二尖瓣环的亚瓣膜区域进行。肿。 第四，通过打浆装置展开具有可变形端部的“C”形保持器，以便将复制的组织保持在复制形式中。 经口途径可用于将二尖瓣心房侧的组织挽留并保留，以减少二尖瓣反流。
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7.发明申请METHOD AND SYSTEM FOR PLICATING TISSUE IN A MINIMALLY INVASIVE MEDICAL PROCEDURE FOR THE TREATMENT OF MITRAL VALVE REGURGITATION 审中-公开用于治疗微孔注射的微型入侵医疗程序中的组织方法和系统公开(公告)号：US20130172990A1
公开(公告)日：2013-07-04
申请号：US13534158
申请日：2012-06-27
申请人： ADAM GROOTHUIS , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
发明人： ADAM GROOTHUIS , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946
摘要： A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form.
摘要翻译： 描述了通过使用由保持器固定的环形或相邻组织的一个或多个点进行重新形成二尖瓣环的治疗二尖瓣反流的系统和方法。 该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。 第一个是具有可脱垂或弯曲的尖端的交叉导管。 第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。 第三，折叠装置然后用于在二尖瓣环的亚瓣膜区域进行。肿。 第四，通过打浆装置展开具有可变形端部的“C”形保持器，以便将复制的组织保持在复制形式中。
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8.发明申请BARE METAL STENT WITH DRUG ELUTING RESERVOIRS HAVING IMPROVED DRUG RETENTION 审中-公开具有改善药物保持性的药物储存库的金属硬骨公开(公告)号：US20120109284A1
公开(公告)日：2012-05-03
申请号：US12915166
申请日：2010-10-29
CPC分类号： A61F2/91 , A61F2250/0068 , Y10T29/4998
摘要： Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions from a stent having reservoirs so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue. Features may be incorporated into the walls and bases of these reservoirs to improve securement of the drug construct.
摘要翻译： 可植入的医疗装置可用于局部递送一种或多种药物或治疗剂以治疗各种各样的病症，包括治疗生物体对引入可植入医疗装置的反应。 这些治疗剂可以在受控和定向的条件下从具有储存器的支架释放，使得一种或多种治疗剂达到正确的靶区域，例如周围组织。 特征可以并入这些储存器的壁和基底中以改善药物构建体的固定。
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9.发明申请INTRAVASCULAR STENT HAVING IMRPROVED DESIGN FOR LOADING AND DEPLOYING 审中-公开具有加载和分配的IMRPROVED设计的血管内支架公开(公告)号：US20100057187A1
公开(公告)日：2010-03-04
申请号：US12198150
申请日：2008-08-26
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/91575 , A61F2002/91591 , A61F2210/0076 , A61F2230/0054 , A61F2250/0036
摘要： A stent may be inserted into a vessel in order to open and then maintain the patency of the vessel. The stent has a strut design that increases the overall fatigue resistance of the stent. Each strut is tapered to better distribute strain and thus increase fatigue resistance. In addition, some of the struts may comprise protrusions to increase the pushability of the stent during loading into a delivery device.
摘要翻译： 可以将支架插入容器中以便打开并且然后维持血管的通畅。 支架具有支柱设计，可增加支架的整体抗疲劳性能。 每个支柱是锥形的，以更好地分布应变，从而增加抗疲劳性。 此外，一些支柱可以包括突起以增加在装载到输送装置中时支架的推动性。
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公开(公告)号：US08444557B2
公开(公告)日：2013-05-21
申请号：US12636232
申请日：2009-12-11
申请人： Patrick M. Schleitweiler , Salvatore G. Caldarise , Michael S. Cropper , Steven G. Hall , Jerome R. Morgan , Theodore R. Farrell , Frederick E. Shelton, IV
发明人： Patrick M. Schleitweiler , Salvatore G. Caldarise , Michael S. Cropper , Steven G. Hall , Jerome R. Morgan , Theodore R. Farrell , Frederick E. Shelton, IV
IPC分类号： A61B1/32
CPC分类号： A61B17/3421 , A61B2017/00986 , A61B2017/2905 , A61B2017/3443 , A61B2017/3484 , A61B2017/349 , A61B2017/3492
摘要： Methods and devices are provided for providing access through tissue to a surgical site. Generally, the methods and devices allow adjustment of a surgical access port's longitudinal length. In one embodiment, a surgical access port is provided that includes a housing having a cannula distally extending therefrom. The housing can be configured to cut a proximal portion of the cannula to adjust a longitudinal length of the cannula and hence of the surgical access port. In another embodiment, a surgical access port is provided that includes a cannula formed of a plurality of modular segments removably coupled together. One or more of the segments can be configured to be removable from the cannula to change the cannula's longitudinal length.
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