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公开(公告)号：US20180321241A1
公开(公告)日：2018-11-08
申请号：US15973025
申请日：2018-05-07
IPC分类号： G01N33/569 , G01N15/14 , A61L27/38
CPC分类号： G01N33/56966 , A61L27/3817 , A61L2300/64 , A61L2430/06 , A61L2430/24 , G01N15/14 , G01N2015/1486
摘要： Compositions and methods are provided for preparing and quantifying multipotential stromal cells derived from bone marrow aspirate for use in regenerative therapy and other medical treatments. A rapid, simple assay can be performed intra-operatively to quantify multipotential stromal cells in a sample for determining a dosage of multipotential stromal cells to be administered in regenerative therapeutic compositions.
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2.发明申请公开(公告)号：US20100076408A1
公开(公告)日：2010-03-25
申请号：US12341493
申请日：2008-12-22
申请人： Matthew Krever , Daniel H. Olsen , Rudolph Cedro , Paul D'Antonio , Eric Gerard Johnson , Wayne Allen Johnson , Tracy Alan Lozano , Matthew Aaron Mason
发明人： Matthew Krever , Daniel H. Olsen , Rudolph Cedro , Paul D'Antonio , Eric Gerard Johnson , Wayne Allen Johnson , Tracy Alan Lozano , Matthew Aaron Mason
IPC分类号： A61M25/098
CPC分类号： A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/003 , A61B2017/00783 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946 , A61B2017/3425 , A61M25/001 , A61M25/0052 , A61M25/0074 , A61M25/0127 , A61M25/0136 , A61M25/0141 , A61M25/0147 , A61M2025/0047 , A61M2025/0079 , A61M2025/015
摘要： A deflecting guide catheter for use in minimally invasive medical procedures such as the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The catheter includes an elongated tubular portion having various durometers along its length and at least one puller wire attached to an anchor band near the distal end. The deflecting guide catheter is used to provide a means for guiding a plication device or other medical instrument into a desired position within the vasculature or heart chambers of a patient.
摘要翻译： 描述了一种用于微创医疗程序的偏转引导导管，例如通过使用由保持器固定的环形或相邻组织的一个或多个引导来重塑二尖瓣环而治疗二尖瓣反流。 该导管包括细长的管状部分，其长度上具有各种硬度计，以及至少一根连接到靠近远端的锚固带的拉线。 偏转引导导管用于提供用于将折叠装置或其他医疗器械引导到患者的脉管系统或心室内的期望位置的装置。
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3.发明申请公开(公告)号：US20090105814A1
公开(公告)日：2009-04-23
申请号：US12249388
申请日：2008-10-10
申请人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
发明人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946
摘要： A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.
摘要翻译： 描述了通过使用由保持器固定的环形或相邻组织的一个或多个点进行重新形成二尖瓣环的治疗二尖瓣反流的系统和方法。 该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。 第一个是具有可脱垂或弯曲的尖端的交叉导管。 第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。 第三，折叠装置然后用于在二尖瓣环的亚瓣膜区域进行。肿。 第四，通过打浆装置展开具有可变形端部的“C”形保持器，以便将复制的组织保持在复制形式中。 经口途径可用于将二尖瓣心房侧的组织挽留并保留，以减少二尖瓣反流。
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公开(公告)号：US20080033572A1
公开(公告)日：2008-02-07
申请号：US11498341
申请日：2006-08-03
申请人： Paul D'Antonio , Joshua Simon , Benjamin T. Cripps
发明人： Paul D'Antonio , Joshua Simon , Benjamin T. Cripps
IPC分类号： A61F2/28
CPC分类号： A61K35/32 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30224 , A61F2002/30677 , A61F2002/4649 , A61F2230/0069 , A61F2310/00293 , A61F2310/00365 , A61K38/39 , A61L27/3608 , A61L27/365 , A61L27/3804 , A61L27/46 , A61L2430/02 , A61K2300/00
摘要： Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.
摘要翻译： 骨移植组合物包含软化骨基质，磷酸钙，胶原和生物传导细胞溶液。 还描述了使用骨移植组合物修复和愈合缺陷和缺失骨的方法。
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公开(公告)号：US20070038303A1
公开(公告)日：2007-02-15
申请号：US11504271
申请日：2006-08-15
申请人： Mark Myerson , Paul D'Antonio , Lisa Thompson , John Sharobiem
发明人： Mark Myerson , Paul D'Antonio , Lisa Thompson , John Sharobiem
CPC分类号： A61B17/562 , A61B2017/00004 , A61F2/28 , A61F2/30942 , A61F2/4202 , A61F2/4225 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359
摘要： A foot/ankle implant and associated method. The foot/ankle implant comprises a composite structure having a ceramic component with a macroprosity and a polymer component filling the macroporosity. The composite structure forms an anatomically-shaped and load-bearing graft for implantation between two bone portions of the foot or ankle to correct associated deformities. The ceramic component is gradually resorbable after implantation, and the composite structure is gradually replaceable by tissue/bone ingrowth.
摘要翻译： 脚/脚踝植入物及相关方法。 脚/脚踝植入物包括具有大孔的陶瓷组分和填充大孔隙的聚合物组分的复合结构。 复合结构形成解剖学形状和承载移植物，用于在足部或脚踝的两个骨部之间植入以纠正相关的畸形。 陶瓷组分在植入后逐渐可再吸收，复合结构可逐渐被组织/骨向内生长。
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公开(公告)号：US20100098673A1
公开(公告)日：2010-04-22
申请号：US12643604
申请日：2009-12-21
申请人： Paul D'ANTONIO , Joshua Simon , Benjamin T. Cripps
发明人： Paul D'ANTONIO , Joshua Simon , Benjamin T. Cripps
CPC分类号： A61K35/32 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30224 , A61F2002/30677 , A61F2002/4649 , A61F2230/0069 , A61F2310/00293 , A61F2310/00365 , A61K38/39 , A61L27/3608 , A61L27/365 , A61L27/3804 , A61L27/46 , A61L2430/02 , A61K2300/00
摘要： Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.
摘要翻译： 骨移植组合物包含软化骨基质，磷酸钙，胶原和生物传导细胞溶液。 还描述了使用骨移植组合物修复和愈合缺陷和缺失骨的方法。
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7.发明授权公开(公告)号：US08226709B2
公开(公告)日：2012-07-24
申请号：US12249388
申请日：2008-10-10
申请人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
发明人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946
摘要： A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.
摘要翻译： 描述了通过使用由保持器固定的环形或相邻组织的一个或多个点进行重新形成二尖瓣环的治疗二尖瓣反流的系统和方法。 该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。 第一个是具有可脱垂或弯曲的尖端的交叉导管。 第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。 第三，折叠装置然后用于在二尖瓣环的亚瓣膜区域进行。肿。 第四，通过打浆装置展开具有可变形端部的“C”形保持器，以便将复制的组织保持在复制形式中。 经口途径可用于将二尖瓣心房侧的组织挽留并保留，以减少二尖瓣反流。
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公开(公告)号：US20060233851A1
公开(公告)日：2006-10-19
申请号：US11402312
申请日：2006-04-11
申请人： Bruce Simon , Robert Ronk , Paul D'Antonio , Jeffrey Schwardt
发明人： Bruce Simon , Robert Ronk , Paul D'Antonio , Jeffrey Schwardt
IPC分类号： A61F13/00
CPC分类号： A61L27/56 , A61F2002/2835 , A61L27/427 , A61L2430/02
摘要： A bone graft material comprising about 50-90% quickly bioresorbable porogen particles and about 10-50% of a calcium matrix material. A bioactive substance can be included in the matrix material, the porogen particles, or both. Commercial packages containing the bone graft materials and methods for repairing bone therewith are also claimed.
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公开(公告)号：US20050015147A1
公开(公告)日：2005-01-20
申请号：US10499228
申请日：2002-12-18
申请人： Jeffrey Schwardt , Paul D'Antonio
发明人： Jeffrey Schwardt , Paul D'Antonio
CPC分类号： A61L27/3683 , A61F2/28 , A61F2/30767 , A61F2/30771 , A61F2/44 , A61F2/442 , A61F2/4465 , A61F2002/2817 , A61F2002/2821 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30112 , A61F2002/30138 , A61F2002/30153 , A61F2002/302 , A61F2002/30202 , A61F2002/30225 , A61F2002/3023 , A61F2002/30235 , A61F2002/3082 , A61F2002/30827 , A61F2002/30836 , A61F2002/30904 , A61F2002/4649 , A61F2230/0004 , A61F2230/0017 , A61F2230/0019 , A61F2230/0065 , A61F2230/0069 , A61F2310/00365 , A61F2310/00958 , A61L27/3608 , A61L27/3658 , A61L2430/38
摘要： Spinal implants having at least one of several attributes, including a surface layer of demineralized bone, a beveled edge, and channels in the faces in contact with adjacent vertebral bodies. Preferably, the implant has a generally planar top surface, a generally planar bottom surface, and a side surface, wherein at least one of the top and bottom surfaces is demineralized to a depth of from 0.8 mm to 3 mm. Preferably, the top and bottom surfaces of the implant are textured. Also preferably, the implant is disk shaped and comprises an insertion side extending at least 10% of the circumference of the implant, wherein the edge formed by the insertion side and the top surface, and the edge formed by the insertion side and the bottom surface, are beveled.
摘要翻译： 具有几个属性中的至少一个的脊椎植入物，包括软骨的表面层，斜边和与相邻椎体接触的面中的通道。 优选地，植入物具有大致平坦的顶表面，大致平坦的底表面和侧表面，其中顶表面和底表面中的至少一个被软化至0.8mm至3mm的深度。 优选地，植入物的顶表面和底表面是有纹理的。 还优选地，植入物是盘形的，并且包括延伸植入物的圆周的至少10％的插入侧，其中由插入侧和顶表面形成的边缘以及由插入侧和底表面形成的边缘 ，是斜面的。
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公开(公告)号：US07621963B2
公开(公告)日：2009-11-24
申请号：US11402312
申请日：2006-04-11
IPC分类号： A61F2/28
CPC分类号： A61L27/56 , A61F2002/2835 , A61L27/427 , A61L2430/02
摘要： A bone graft material comprising about 50-90% quickly bioresorbable porogen particles and about 10-50% of a calcium matrix material. A bioactive substance can be included in the matrix material, the porogen particles, or both. Commercial packages containing the bone graft materials and methods for repairing bone therewith are also claimed.
摘要翻译： 一种骨移植材料，其包含约50-90％的快速生物再吸收致孔剂颗粒和约10-50％的钙基质材料。 生物活性物质可以包括在基质材料，致孔剂颗粒中，或两者中。 还要求保护含有骨移植材料的商业包装和用于修复骨的方法。
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