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1.发明申请Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods 审中-公开组织样本中复杂肽混合物的有效定量和改进的治疗方法公开(公告)号：US20090275496A1
公开(公告)日：2009-11-05
申请号：US12316297
申请日：2008-12-10
申请人： Sam Baldwin , Dustan Bonnin , Keith Johnson , Jeff Krieger , James Rasmussen , Bei Yu , Eric Zanelli , Jianxin Zhang , Kathryn H. Collins , Michelle Genova , Joseph Kovalchin
发明人： Sam Baldwin , Dustan Bonnin , Keith Johnson , Jeff Krieger , James Rasmussen , Bei Yu , Eric Zanelli , Jianxin Zhang , Kathryn H. Collins , Michelle Genova , Joseph Kovalchin
CPC分类号： A61K31/785 , A61K9/0019 , A61K38/07 , A61K38/16 , C07K5/101 , C07K5/1016 , G01N33/564 , G01N33/6842
摘要： The instant invention provides methods for the detection and quantitation of complex peptide mixtures in tissue samples and functional readouts of the results of administration of such complex peptide mixtures. The instant invention further provides methods for administering complex peptide mixtures to a subject in need thereof, the dosage regimen and quantity determined based on the above mentioned method for detection and quantitation.
摘要翻译： 本发明提供了检测和定量组织样品中复合肽混合物的方法以及这种复合肽混合物施用结果的功能性读出方法。 本发明还提供了向有需要的受试者施用复合肽混合物的方法，基于上述检测和定量方法确定的剂量方案和量。
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公开(公告)号：US20060194725A1
公开(公告)日：2006-08-31
申请号：US11283405
申请日：2005-11-17
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
IPC分类号： A61K38/17
CPC分类号： C07K14/435 , A61K9/0019 , A61K31/785 , A61K38/02
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US07655221B2
公开(公告)日：2010-02-02
申请号：US11283406
申请日：2005-11-17
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC分类号： A61K38/02 , A61K38/16 , A61K2300/00
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US20100316714A1
公开(公告)日：2010-12-16
申请号：US12637723
申请日：2009-12-14
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC分类号： A61K38/02 , A61K38/16 , A61K2300/00
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US08475779B2
公开(公告)日：2013-07-02
申请号：US12637723
申请日：2009-12-14
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC分类号： A61K38/02 , A61K38/16 , A61K2300/00
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US20060189527A1
公开(公告)日：2006-08-24
申请号：US11283406
申请日：2005-11-17
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
IPC分类号： A61K38/16
CPC分类号： A61K38/02 , A61K38/16 , A61K2300/00
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
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公开(公告)号：US20140249089A1
公开(公告)日：2014-09-04
申请号：US14169672
申请日：2014-01-31
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zannelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zannelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
IPC分类号： C07K14/435
CPC分类号： C07K14/435 , A61K9/0019 , A61K31/785 , A61K38/02
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US20080194462A1
公开(公告)日：2008-08-14
申请号：US10591315
申请日：2005-09-15
申请人： Kai Wucherpfennig , James Rasmussen , Bei Yu , Eric Zanelli , Jack L. Strominger
发明人： Kai Wucherpfennig , James Rasmussen , Bei Yu , Eric Zanelli , Jack L. Strominger
IPC分类号： A61K38/28 , A61K38/16 , G01N33/566 , A61P3/10 , A61P37/00
CPC分类号： A61K38/02
摘要： The present invention provides methods and compositions for treating autoimmune diseases and other unwanted immune reactions comprising administering a copolymer that binds to one or more HLA-DQ molecules and modulates DQ-restricted T cell responses. The copolymers are random copolymers of amino acids and copolymers comprising anchor residues to facilitate binding to the DQ binding pockets.
摘要翻译： 本发明提供用于治疗自身免疫性疾病和其他不需要的免疫反应的方法和组合物，其包括施用与一种或多种HLA-DQ分子结合并调节DQ限制性T细胞应答的共聚物。 共聚物是氨基酸的无规共聚物和包含锚定残基的共聚物，以便于结合DQ结合袋。
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9.发明授权Identification of self and non-self antigens implicated in autoimmune diseases 失效鉴定涉及自身免疫性疾病的自身和非自身抗原公开(公告)号：US07084247B2
公开(公告)日：2006-08-01
申请号：US10799005
申请日：2004-03-11
申请人： James Rasmussen , Bei Yu
发明人： James Rasmussen , Bei Yu
IPC分类号： A61K38/04
CPC分类号： C07K14/4713 , A61K39/0008
摘要： The present invention provides isolated peptides relating to the autoimmune disease pemphigus vulgaris. The peptides relating to pemphigus vulgaris are self epitopes derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.
摘要翻译： 本发明提供了与自身免疫性疾病寻常型天疱疮相关的分离的肽。 与寻常型天疱疮有关的肽是衍生自人类病原体的自身表位，其涉及病因和疾病的缓解。 提供了用于耐受和/或免疫个体的药物制剂以及与其有关的方法。 提供了用于鉴定涉及人自身免疫疾病的其他自身和非自身表位的方法，并且还提供了类似的药物制剂和用于这些表位的方法。
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10.发明申请Identification of self and non-self antigens implicated in autoimmune diseases 审中-公开鉴定涉及自身免疫性疾病的自身和非自身抗原公开(公告)号：US20060159672A1
公开(公告)日：2006-07-20
申请号：US11388121
申请日：2006-03-23
申请人： James Rasmussen , Bei Yu
发明人： James Rasmussen , Bei Yu
IPC分类号： A61K39/395 , A61K31/70 , C07K16/42
CPC分类号： C07K14/4713 , A61K39/0008
摘要： The present invention provides isolated peptides relating to the autoimmune disease Pemphigus vulgaris. The peptides relating to Pemphigus vulgaris are self epitopes derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.
摘要翻译： 本发明提供了与自身免疫病天疱疮有关的分离的肽。 与寻常型天疱疮相关的肽是衍生自人类病原体的自身表位，其涉及疾病的病因和缓解。 提供了用于耐受和/或免疫个体的药物制剂以及与其有关的方法。 提供了用于鉴定涉及人自身免疫疾病的其他自身和非自身表位的方法，并且还提供了类似的药物制剂和用于这些表位的方法。
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